Discovery of the First Low-Luminosity Quasar at z > 7

We report the discovery of a quasar at z = 7.07, which was selected from the deep multi-band imaging data collected by the Hyper Suprime-Cam (HSC) Subaru Strategic Program survey. This quasar, HSC J124353.93+010038.5, has an order of magnitude lower luminosity than do the other known quasars at z > 7. The rest-frame ultraviolet absolute magnitude is M1450 = -24.13 +/- 0.08 mag and the bolometric luminosity is Lbol = (1.4 +/- 0.1) x 10^{46} erg/s. Its spectrum in the optical to near-infrared shows strong emission lines, and shows evidence for a fast gas outflow, as the C IV line is blueshifted and there is indication of broad absorption lines. The Mg II-based black hole mass is Mbh = (3.3 +/- 2.0) x 10^8 Msun, thus indicating a moderate mass accretion rate with an Eddington ratio 0.34 +/- 0.20. It is the first z > 7 quasar with sub-Eddington accretion, besides being the third most distant quasar, known to date. The luminosity and black hole mass are comparable to, or even lower than, those measured for the majority of low-z quasars discovered by the Sloan Digital Sky Survey, and thus this quasar likely represents a z > 7 counterpart to quasars commonly observed in the low-z universe.Comment: Accepted for publication in ApJ Letter

Subaru High-z Exploration of Low-luminosity Quasars (SHELLQs). X. Discovery of 35 Quasars and Luminous Galaxies at 5.7 ≤ z ≤ 7.0

The American Astronomical Society, find out more The Institute of Physics, find out more THE FOLLOWING ARTICLE ISOPEN ACCESS Subaru High-z Exploration of Low-luminosity Quasars (SHELLQs). X. Discovery of 35 Quasars and Luminous Galaxies at 5.7 ≤ z ≤ 7.0 Yoshiki Matsuoka1, Kazushi Iwasawa2, Masafusa Onoue3, Nobunari Kashikawa4,5,6, Michael A. Strauss7, Chien-Hsiu Lee8, Masatoshi Imanishi5,6, Tohru Nagao1, Masayuki Akiyama9, Naoko Asami10Show full author list Published 2019 October 3 © 2019. The American Astronomical Society. The Astrophysical Journal, Volume 883, Number 2 DownloadArticle PDF DownloadArticle ePub Figures Tables References Download PDFDownload ePub 674 Total downloads 99 total citations on Dimensions. Turn on MathJax Share this article Share this content via email Share on Facebook Share on Twitter Share on Google+ Share on Mendeley Article information Abstract We report the discovery of 28 quasars and 7 luminous galaxies at 5.7 ≤ z ≤ 7.0. This is the tenth in a series of papers from the Subaru High-z Exploration of Low-Luminosity Quasars (SHELLQs) project, which exploits the deep multiband imaging data produced by the Hyper Suprime-Cam (HSC) Subaru Strategic Program survey. The total number of spectroscopically identified objects in SHELLQs has now grown to 93 high-z quasars, 31 high-z luminous galaxies, 16 [O iii] emitters at z ~ 0.8, and 65 Galactic cool dwarfs (low-mass stars and brown dwarfs). These objects were found over 900 deg2, surveyed by HSC between 2014 March and 2018 January. The full quasar sample includes 18 objects with very strong and narrow Lyα emission, whose stacked spectrum is clearly different from that of other quasars or galaxies. While the stacked spectrum shows N v λ1240 emission and resembles that of lower-z narrow-line quasars, the small Lyα width may suggest a significant contribution from the host galaxies. Thus, these objects may be composites of quasars and star-forming galaxies

Discovery of the First Low-luminosity Quasar at z > 7

We report the discovery of a quasar at z = 7.07, which was selected from the deep multi-band imaging data collected by the Hyper Suprime-Cam (HSC) Subaru Strategic Program survey. This quasar, HSC J124353.93+010038.5, has an order of magnitude lower luminosity than do the other known quasars at z > 7. The rest-frame ultraviolet absolute magnitude is M1450 = −24.13 ± 0.08 mag and the bolometric luminosity is ${L}_{\mathrm{bol}}\,=(1.4\pm 0.1)\,\times \,{10}^{46}$ erg s−1. Its spectrum in the optical to near-infrared shows strong emission lines, and shows evidence for a fast gas outflow, as the C iv line is blueshifted and there is indication of broad absorption lines. The Mg ii-based black hole mass is ${M}_{\mathrm{BH}}=(3.3\pm 2.0)\times {10}^{8}{M}_{\odot }$, thus indicating a moderate mass accretion rate with an Eddington ratio ${\lambda }_{\mathrm{Edd}}=0.34\pm 0.20$. It is the first z > 7 quasar with sub-Eddington accretion, besides being the third most distant quasar known to date. The luminosity and black hole mass are comparable to, or even lower than, those measured for the majority of low-z quasars discovered by the Sloan Digital Sky Survey, and thus this quasar likely represents a z > 7 counterpart to quasars commonly observed in the low-z universe

Exploring deep microbial life in coal-bearing sediment down to ~2.5 km below the ocean floor

Peer reviewedPostprin

DOCK2 is involved in the host genetics and biology of severe COVID-19

「コロナ制圧タスクフォース」COVID-19疾患感受性遺伝子DOCK2の重症化機序を解明 --アジア最大のバイオレポジトリーでCOVID-19の治療標的を発見--. 京都大学プレスリリース. 2022-08-10.Identifying the host genetic factors underlying severe COVID-19 is an emerging challenge. Here we conducted a genome-wide association study (GWAS) involving 2, 393 cases of COVID-19 in a cohort of Japanese individuals collected during the initial waves of the pandemic, with 3, 289 unaffected controls. We identified a variant on chromosome 5 at 5q35 (rs60200309-A), close to the dedicator of cytokinesis 2 gene (DOCK2), which was associated with severe COVID-19 in patients less than 65 years of age. This risk allele was prevalent in East Asian individuals but rare in Europeans, highlighting the value of genome-wide association studies in non-European populations. RNA-sequencing analysis of 473 bulk peripheral blood samples identified decreased expression of DOCK2 associated with the risk allele in these younger patients. DOCK2 expression was suppressed in patients with severe cases of COVID-19. Single-cell RNA-sequencing analysis (n = 61 individuals) identified cell-type-specific downregulation of DOCK2 and a COVID-19-specific decreasing effect of the risk allele on DOCK2 expression in non-classical monocytes. Immunohistochemistry of lung specimens from patients with severe COVID-19 pneumonia showed suppressed DOCK2 expression. Moreover, inhibition of DOCK2 function with CPYPP increased the severity of pneumonia in a Syrian hamster model of SARS-CoV-2 infection, characterized by weight loss, lung oedema, enhanced viral loads, impaired macrophage recruitment and dysregulated type I interferon responses. We conclude that DOCK2 has an important role in the host immune response to SARS-CoV-2 infection and the development of severe COVID-19, and could be further explored as a potential biomarker and/or therapeutic target

Studies on inhibitors of enzymes involved in tumor metastasis from marine invertebrates

報告番号: 甲24703 ; 学位授与年月日: 2009-03-23 ; 学位の種別: 課程博士 ; 学位の種類: 博士(農学) ; 学位記番号: 博農第3413号 ; 研究科・専攻: 農学生命科学研究科水圏生物科学専

海洋無脊椎動物からのがん転移関連酵素阻害物質に関する研究

University of Tokyo (東京大学

Thermal- and pH-Dependent Size Variable Radical Nanoparticles and Its Water Proton Relaxivity for Metal-free MRI Functional Contrast Agents

For development of the metal-free MRI contrast agents, we prepared the supra-molecular organic radical, TEMPO-UBD, carrying TEMPO radical, as well as the urea, alkyl group, and phenyl ring, which demonstrate self-assembly behaviors using noncovalent bonds in an aqueous solution. In addition, TEMPO-UBD has the tertiary amine and the oligoethyleneglycol chains (OEGs) for the function of pH and thermal responsiveness. By DLS and TEM imaging, the resulting self-assembly was seen to form the spherical nano-particles 10 – 150 nm in size. On heating, interestingly, the nano-particles showed a lower critical solution temperature (LCST) behavior having two-step variation. This double-LCST behavior is the first such example among the supra-molecules. To evaluate of the ability as MRI contrast agents, the values of proton (1H) longitudinal relaxivity (r1) were determined using MRI apparatus. In conditions below and above CAC at pH 7.0, the distinguishable r1 values were estimated to be 0.17 and 0.21 mM(-1)s(1), indicating the suppression of fast tumbling motion of TEMPO moiety in a nano-particle. Furthermore, r1 values became larger in the order of pH 7.0 > 9.0 > 5.0. Those thermal and pH dependencies indicated the possibility of metal-fee MRI functional contrast agents in the future