Relationship of Corporate Governance with Organizational Resilience in the Changing World

In addition to economical changes,technological improvemenets and crisis; occured  company scandals like Enron and  Worldcom has increased the interest in corporate governance concept. While corporate governance principles created by OECD in international  context, in our country the principles created by SPK based on Anglo-Saxon corporate governance model. To encourage firms about adopting corporate governance and measure adoption level of  firms who enrolled to stock markets to the codes in question, XKURY has been created by İstanbul Stock Market. When the effects of changes and developments in the fields of economy and technology on the management understanding and strategies of the enterprises considered, ability of the businesses that have adopted corporate governance principles to continue their activities in a healthy way, even if environmental factors become difficult or encounter any destructive events raises questions regarding to the relationahip between corporate governance and organizational resilience. This research has been made to understand if there is a correlation between corporate governance and organizational resilience. While data regarding to corporate governance point acquired as secondary sources via XKURY, data regarding to organizational resilience has been acquired as primary source via a survey that made up of organizational resilience scale created by Wicker et al. For dependent variable of the work, samples picked via snowball sampling method and collected data analyzed on the last word statistic softwares and Excel 2016. Analyze results showed that there is strong positive way correlation between corporate governance and organizational resilience

A quadricuspid aortic valve causing moderate aortic regurgitation

Quadricuspid aortic valve (QAV) is a rare cause of aortic regurgitation. Most cases are detected incidentally during echocardiography, angiography, autopsy or surgery. It may also be associated with other congenital anomalies of the heart. A 70 year-old man was admitted to our hospital with a five-month history of dyspnea. Echocardiographic examination showed a QAV leading to moderate aortic regurgitation, severe mitral regurgitation, left ventricular dysfunction and aortic root dilatation. Surgical treatment was considered, but the patient refused. We describe a case of QAV leading to aortic regurgitation

Relationship of Corporate Governance with Organizational Resilience in the Changing World

In addition to economical changes,technological improvemenets and crisis; occured company scandals like Enron and Worldcom has increased the interest in corporate governance concept. While corporate governance principles created by OECD in international context, in our country the principles created by SPK based on Anglo-Saxon corporate governance model. To encourage firms about adopting corporate governance and measure adoption level of firms who enrolled to stock markets to the codes in question, XKURY has been created by İstanbul Stock Market. When the effects of changes and developments in the fields of economy and technology on the management understanding and strategies of the enterprises considered, ability of the businesses that have adopted corporate governance principles to continue their activities in a healthy way, even if environmental factors become difficult or encounter any destructive events raises questions regarding to the relationahip between corporate governance and organizational resilience. This research has been made to understand if there is a correlation between corporate governance and organizational resilience. While data regarding to corporate governance point acquired as secondary sources via XKURY, data regarding to organizational resilience has been acquired as primary source via a survey that made up of organizational resilience scale created by Wicker et al. For dependent variable of the work, samples picked via snowball sampling method and collected data analyzed on the last word statistic softwares and Excel 2016. Analyze results showed that there is strong positive way correlation between corporate governance and organizational resilience

Protein expression changes in breast cancer and their importance

Studies about nucleic acids have increased after thepublication of DNA’s three dimensional structure by Watsonand Crick. Nucleic acids are the heritable moleculeswhich contain codes for proteins. Proteins are the mostimportant elements in molecular world because they arethe basic structural and functional components of a livingorganism. Clarifying the celluler events that involve proteinsare important in many areas for example diagnosisand treatment determination of diseases or developmentof new drugs. Proteome that comes from a combinationof the terms protein and genome, is one of the importantfield in these days. The studies in this area have acceleratedand gained a different place especially with afterthe completion of human genome project. In synthesis ofa protein just only genetic information is not enough. Atthe same time the change or changes of a protein afterthe synthesis, the final version and transporting to finallocalization of it also important. Because having defects inmailing cells of breast cancer, the first targets of treatmentmust be proteins. In this way the studies on proteins areimportant to determine prognostic and diagnostic diseasemarkers and also significant for identifying new treatmentstrategies.Key words: Genom, proteom, breast cance

Color stability and surface roughness of a laboratory-processed composite resin as a function of mouthrinse

WOS: 000365431800009PubMed ID: 26179446Statement of the Problem: Mouthrinses can cause discoloration on indirect resin composites. Purpose of the Study: The purpose of the study was to investigate the effect of different mouthrinses on the color changes and surface roughness of a laboratory-processed composite. Methods and Materials: Fifty discs were made using GC Gradia/GC indirect composites and divided into five groups which immersed in artificial saliva and four different types of mouthrinses. The samples were immersed daily for 14 days in 20 mL of the solutions for 2 minutes twice a day (with a 12-hour interval between exposures). Measurements were carried out at four different times: 1 hour after sample preparation (t(0)), 1 day (t(1)), 7 days (t(2)), and 14 days (t(3)) after the first immersion in the solutions. The color before and after immersion was measured according to Comission Internationale de L'Eclairage (CIE L*, a*, b*) System and Delta L*, Delta a*, Delta b*, and Delta E* values were calculated. The surface roughness Ra (mu m) of the specimens was evaluated using a profilometer. Results: There were significant differences between the groups at all time representing Delta E values (p < 0.001). At (t(1)) time representing Delta Ra value, there were significant differences between the groups (p < 0.05). At (t(2), t(3)) time representing Delta Ra values, there were significant differences between the groups (p < 0.001). Pharmol Zn immersed specimens showed Delta E values between 1.04 and 3.67. Conclusions: The result of this study indicated that the mouthrinses affected the color stability of indirect composites. CLINICAL SIGNIFICANCE Based on the results of this study, patients with resin composite restorations should be warned by the dentists about the discoloration of the restorations and the time period of the mouthrinse that will be used

Percutaneous surgery using Admix NoKorTM Non-Coring 16 G needle in cases with trigger finger

In this study mid- and long-term outcomes of the cases with trigger finger we treated using Admix NoKorTM have been presented. Percutaneous release procedures were applied for 24 fingers of 22 (19 female, 3 male patients; mean age, 57; range, 39-72) patients between May 2009 and May 2011. Preoperatively US was performed so as to confirm the presence of trigger finger. Diameters of the tendons of the affected and intact hands measured using US, were compared so as to be able to demonstrate thickening of the tendon of the trigger finger. The patients were monitored for an average period of 25.2 (range, 14-36) months. During surgery, clinically loss of the catching sensation was observed. In two patients percutaneous trigger finger release failed, so we have to proceed with open surgery. During open surgery, we observed longitudinal wounds on the tendon. One patient developed unilateral radial digital nerve damage. Percutaneous release of the trigger finger using Admix NoKorTM 16-G gauge needle can be preferred in the treatment of trigger finger. Trigger finger of the first digit requires more attentive approach and one should be aware of the complications. If required open surgery can be preferred. [Med-Science 2017; 6(3.000): 551-6

The effect of tramadole HCL and paracetamol on fracture healing in rat tibia model

In our research, we aim to study the effects of combined usage of tramadole HCl + paracetamol on rat tibia fracture model. In our study, 60 Wistar-Albino type male rats, weighted at 300-350 g., were divided as control and test ( tramadole HCl + paracetamol) groups Under general anesthesia, standard closed fractures were created on right tibias of all rats using blunt ended needle holder with three point principle and then closed reduction and fixing with intramedullary nail (0.7 mm) were provided. After fracture treatment of 30 rats in the test group, starting at the same day, 40mg/kg/day tramadole HCL was introduced as daily intermuscular dosage until they were sacrificed. Rats were sacrificed after the fractures as groups of 10 individuals at 2nd, 4th and 6th weeks. Healing fractured tibias were examined mechanically, radiologically, histopathologically. Results: No positive or negative radiological, biochemical and histological effect was detected after the long duration of tramadole HCL + paracetamol usage, starting from the first day and reaching to 6 weeks, in healing process of closed tibia fractures created and fixed with IM nails in rats. Considering the negative effects of NSAIDs on fracture healing, we think that tramadole HCl + paracetamol combination is a safe option in postoperative pain treatment after fracture. [Med-Science 2017; 6(1.000): 81-5

Salubrinal Ameliorates Inflammation and Neovascularization via the Caspase 3/Enos Signaling in an Alkaline-Induced Rat Corneal Neovascularization Model

Background and Objectives: Ocular alkaline burn is a clinical emergency that can cause permanent vision loss due to limbal stem cell deficiency and corneal neovascularization (CNV). Although the basic pathogenetic mechanisms are considered to be acute oxidative stress and corneal neovascularization triggered by inflammation, the underlying intracellular mechanisms have not been clearly elucidated. The aim of this study was to investigate the role of endoplasmic reticulum (ER) stress on inflammation and neovascularization, and the effect of the ER stress inhibitor salubrinal (SLB), as a novel treatment in a corneal alkaline burn model in rats. Methods: Chemical burns were created by cautery for 4 s using a rod coated with 75% silver nitrate and 25% potassium nitrate in the corneal center for the corneal neovascularization (CNV) model. Twenty-eight Wistar albino rats were divided into four groups: SHAM, CNV, CNV + SLB, and CNV + bevacizumab (BVC). After the CNV model was applied to the right eye, a single subconjunctival dose (0.05 mL) of 1 mg/kg salubrinal was injected into both eyes in the CNV + SLB group. A total of 1.25 mg/mL of subconjunctival BVC was administered to the CNV + BVC group. Fourteen days after experimental modeling and drug administration, half of the globes were placed in liquid nitrogen and stored at −20 °C until biochemical analysis. The remaining tissues were collected and fixed in 10% buffered formalin for histopathological and immunohistochemical analysis. Three qualitative agents from three different pathways were chosen: TNFR for inflammation, endothelial nitric oxide synthase (e-NOS) for vascular endothelial growth factor (VEGF)-mediated vascular permeability, and caspase-3 for cellular apoptosis. Results: Significantly lower caspase-3 and eNOS levels were detected in the CNV + SLB and CNV + BVC groups than in the CNV group. Additionally, histopathological evaluation revealed a significant decrease in neovascularization, inflammatory cell infiltration, and fibroblast activity in the CNV + SLB and CNV + BVC groups. The endoplasmic reticulum stress inhibitor, salubrinal, administered to the treatment group, attenuated apoptosis (caspase-3) and inflammation (e-NOS). In the control group (left eyes of the SLB group), salubrinal did not have a toxic effect on the healthy corneas. Conclusion: The ER stress pathway plays an important role in angiogenesis after alkaline corneal burns, and treatment with SLB modulates this pathway, reducing caspase-3 and eNOS levels. Further studies are needed to understand the molecular mechanisms altered by SLB-mediated therapy. The fact that more than one mechanism plays a role in the pathogenesis of CNV may require the use of more than one molecule in treatment. SLB has the potential to affect multiple steps in CNV pathogenesis, both in terms of reducing ER stress and regulating cellular homeostasis by inhibiting the core event of integrated stress response (ISR). Therefore, it can be used as a new treatment option and as a strengthening agent for existing treatments. Although blockade of intracellular organelle stress pathways has shown promising results in experimental studies, more in-depth research is needed before it can be used in routine practice. To the best of our knowledge, this study is the first to report the role of ER stress in corneal injury