The Association of Viral Infection and Acute Leukemia in Childhood: Two Case Reports

Hepatitis A and Measles are the most common viral infection in pediatric patients. Viral infections causes to serious problem in immunocompromised patients such as acute leukemias. It is known that some viral infection agent causes hematologic malignancies. We report here two patient with acute leukemias who admitted to our clinic with similar to viral infection. The first case is a patient with acute lymphoblastic leukemia (ALL) presented with ascites and pleural effusion. In this patient, the major clinical problem is hepatitis A. The second case is a patient with ALL who admitted with symptoms of measles. We discussed here, some viral infections may cause to leukemia and those may be associated with leukemias

Non-Traumatic Subcapsular Spleen Hematoma in a Patient with Brucellosis

Brucellosis is a zoonotic disease. A characteristic clinical findings are fever, headache, arthralgia and splenomegali. Brucellosis occurs after direct contact with an infected animal or consumption of products of an infected animal. Subcapsular hematoma in the spleen is very rare complication of brucella infection. We report here, an 11 year old patient with brucellosis who admitted to our clinic with subcapsular non-traumatic spleen hematoma. Hematoma and clinical findings were resolved with doxicyclin and streptomycin combination. We emphasised that brucella infection should be keept in mind when non-traumatic subcapsular spleen hematoma occur

The Use Of Feiba In Hemophilia A Patient With Inhibitory And Sign Of Severe Intraabdominal Hemorrhage

The development of a factor VIII inhibitory is the most serious problem of Hemophilia A. High dose FVIII, recombinant FVIIa or FVIII inhibitor bypass activator (FEIBA) only or combined may use in the treatment of hemophilia with inhibitory. We present here 42 year-old male was admitted to our clinic with sign of shock, abdominal tenderness and image of mass. In laboratory, Hemoglobin was found 5 gr/dl, aPTT: 106 sec, FVIII: %0 and inhibitory level was found 14 BU. Abdominal computerized tomography was shown hemorrhage in abdominal cavity and in psoas muscle. In treatment; We used blood transfusion and 100 U/kgx2/d FEIBA along 4 days. General symptoms and signs was healed after 2 days and hematologic parameters turned to normal. Immune tolerans treatment program was planned for patient, later. FEIBA treatment is very useful in hemophilia patients suffered from hemorrhage and inhibitors in addition to supportive treatment

B12 Vitamin and Folat Prevelance of Children and Adolescents in Diyarbakır

The most common cause of megaloblastic anemia in childhood are vitamin B12 and folat deficiency. Folat and vitamin B12 play a role in DNA synthessis in gastrointestinal, urogenital,nerves and hemotopoetic cells. The diagnosis of megaloblastic anemia is easy and the treatment cost is low.In this study, the prevalence of vitamin B12 and folat deficiencies in 889 students were determined. Vitamin B12 and folat levels in blood samples were measured via RİAThe average age were betwen 12 and 22 years. Of this students 294(%33,1) were female and 595 (%66,9) were male. The incidence of vitamin B12 deficiency was found to be 2.2%, while folat deficiency was 21.8%. The mean vitamin B12 level was 331,51±144,05 pg/mL (325,60±138,91 in pg/mL male, 343,48±153,48 pg/mL in female), the mean folat level was 5,42±2,12 ng/ml (5,23±2,11 ng/ml in male, 5,80±2,10 ng/ml in female).The prevelance of folat deficiency in our region was higher than other countries, possibly due to low socioeconomical status, improper or inadequate food intake and low educational status

Nadir faktör eksikliği tanılı 36 olgunun değerlendirilmesi

Introduction: Rare factor deficiencies are predominantly autosomal recessively inherited disorders with a frequency of approximately 1: 500000 to 1: 2000000 in the general population. They account for 3-5% of all inherited coagulation disorders. In this study, we aimed to evaluate the demographic features and clinical findings of 36 patients who were followed up and treated with the diagnosis of rare factor deficiency. Materials and Methods: A total of 36 patients aged between 0-16 years diagnosed with rare coagulation deficiencies were evaluated in terms of demographic, physical examination, clinical follow-up, and laboratory findings at the Dicle University Pediatric Hematology Unit. Ethics committee approval was obtained from Dicle University for the study on 16.03.2018 with decision no 115. Results: Rare factor deficiencies were diagnosed in 36 (35 %) of 103 patients who were followed up with coagulation disorders. Hemophilia a, hemophilia b, and von Willebrand disease constituted 67 of our patients. Familial consanguinity was present in 75, 6 %, and positive family history was found at 16.6% of the patients. 11 (32.4%) of our patients were diagnosed under the age of one year. Most of our patients diagnosed with factor X deficiency (38.8%). The most common symptoms were mucocutaneous bleeding (50%). Intracranial hemorrhage was detected in 7 (%19,5) patients. Conclusions: Early diagnosis and treatment are very important in the case of rare factor deficiency since severe bleeding complications such as intracranial hemorrhage may develop. Rare factor deficiencies are seen more frequently in places where consanguineous marriage is more common than the general population. Families should be informed about this issue, and family screening should be done early.Giriş: Nadir faktör eksiklikleri; çoğunlukla otozomal resesif geçiş gösteren,prevalansı 1/ 500.000 -1/2.000.000 arasında değişen pıhtılaşma faktör eksiklikleridir. Kalıtsal pıhtılaşma faktör eksikliklerinin %3-5’ini oluşturmaktadır. Bu çalışmada, nadir faktör eksikliği tanısı ile takip ve tedavi ettiğimiz hastaların demografik özellikleri ve klinik bulguları değerlendirilmiştir. Gereç ve Yöntem: Çalışmamızda, Dicle Üniversitesi Tıp Fakültesi Çocuk Hematolojisi ve Onkolojisi biriminde nadir faktör eksikliği tanısı ile takip ve tedavi edilen, yaşları 0-16 yıl arasında değişen toplam 36 hasta değerlendirilmiştir. Hastaların demografik özellikleri,klinik izlem sonuçları ve labaratuar verileri incelenmiştir.Çalışma için Dicle Üniversitesi’nden 16.03.2018 tarihinde 115 nolu karar ile etik kurul onayı alınmıştır. Bulgular: Kalıtsal faktör eksikliği nedeniyle takip ve tedavi ettiğimiz 103 hastanın 36’sında (% 35) nadir faktör eksikliği tanısı mevcuttu. Hastalarımızın 67’sini hemofili A, hemofili B ve von Willebrand hastalığı oluşturuyordu. Anne ve babaların akrabalık oranı % 75,6 olup,aile öyküsü %16.6 olarak bulunmuştur. Hastalarımızın 11’i (%32,4) bir yaşından önce tanı almıştır.Hasta grubumuzda %38,8 oranı (14 hasta) ile FX eksikliği en fazla görülmektedir.Tanı anında en sık başvuru semptomunu %50 ile cilt-mukoza kanamaları oluşturmaktaydı. Ciddi kanamalardan intrakranial kanama yedi (%19,5) hastada görülmüştür. Sonuç: İntrakranial kanama gibi ciddi kanama komplikasyonlarıyla seyretmesinden dolayı nadir faktör eksikliğinde erken tanı ve tedavi çok önemlidir. Nadir faktör eksiklikleri, akraba evliliğinin fazla görüldüğü yerlerde genel popülasyona oranla sık görülmektedir. Ailelerin bu konuda bilgilendirilmesi,aile taramalarının erken dönemde yapılması gerekliliktir

Bankacılık sektöründe bireysel krediler ve bankaların mali tablolarına etkileri

ÖZETBu çalışmada bankacılık sektöründe bireysel krediler ve bireysel kredilerin bankaların mali tablolarına etkileri incelenecektir. Çalışmamızın amacı, bireysel kredilerin mali tablolar üzerinde yer alan etkilerini ortaya koymaktır. Çalışmada ilk olarak, bireysel kredi kullandırımının banka mali tabloları üzerindeki etkileri anlatılmıştır. Bölümde, uygulamalı bir örnek verilmiştir. İkinci bölümde krediler, bireysel krediler ve bireysel kredilerde kredilendirme sürecine yer verilmiştir. Üçüncü bölümde, bankacılık mevzuatında kredi ile ilgili yer alan düzenlemelere değinilmiştir. Dördüncü bölümde, Türk Bankacılık Sektörü mali tablolar üzerinden değerlendirilmiş; sektör bilançosu ile gelir tablosu incelenmiştir.Beşinci bölümde, bireysel krediler grafiklerin yardımıyla çeşitli açılardan incelenmiştir. Bu bölümde 2004 Aralık ile 2010 Mart tarihleri aralığında trend analizi yapılmıştır.Anahtar Kelimeler: Türk Bankacılık Sektörü, Kredi, Bireysel Kredi, Bilanço, Gelir Tablosu, Konut Kredisi, Taşıt Kredisi, İhtiyaç Kredisi, Kredi Kartı.ABSTRACTThis paper analyses the consumer loans and the effect of the consumer loans to the financial statements at the banking sector. The purpose of the study is to state the effect of the consumer loans on the financial statements.In the first section of the study, the effect of using consumer loans on banks financial statements will be explained. In this section, an example is given to show the practice. In the second section; loans, consumer loans and the loan process is explained. In the third section, the arrangements about loans at banking regulation will be discussed. In the fourth section, Turkish Banking Sector is evaluated on the financial statements and the balance sheet, income statement of the sector will be discussed.In the fifth section, consumer loans are evaluated from different aspects helping of graphics. In this section, there is a trend analysis between December 2004 and March 2010.Keywords: Turkish Banking Sector, Loan, Consumer Loan, Balance Sheet, Income Statement, Real Estate Loan, Automotive Loan, Consumer Loan, Credit Card, Profit

Bankacılık sektöründe bireysel krediler ve bankaların mali tablolarına etkileri

Bu çalışmada bankacılık sektöründe bireysel krediler ve bireysel kredilerin bankaların mali tablolarına etkileri incelenecektir. Çalışmamızın amacı, bireysel kredilerin mali tablolar üzerinde yer alan etkilerini ortaya koymaktır. Çalışmada ilk olarak, bireysel kredi kullandırımının banka mali tabloları üzerindeki etkileri anlatılmıştır. Bölümde, uygulamalı bir örnek verilmiştir. İkinci bölümde krediler, bireysel krediler ve bireysel kredilerde kredilendirme sürecine yer verilmiştir. Üçüncü bölümde, bankacılık mevzuatında kredi ile ilgili yer alan düzenlemelere değinilmiştir. Dördüncü bölümde, Türk Bankacılık Sektörü mali tablolar üzerinden değerlendirilmiş; sektör bilançosu ile gelir tablosu incelenmiştir. Beşinci bölümde, bireysel krediler grafiklerin yardımıyla çeşitli açılardan incelenmiştir. Bu bölümde 2004 Aralık ile 2010 Mart tarihleri aralığında trend analizi yapılmıştır. Anahtar Kelimeler: Türk Bankacılık Sektörü, Kredi, Bireysel Kredi, Bilanço, Gelir Tablosu, Konut Kredisi, Taşıt Kredisi, İhtiyaç Kredisi, Kredi Kartı. ABSTRACT This paper analyses the consumer loans and the effect of the consumer loans to the financial statements at the banking sector. The purpose of the study is to state the effect of the consumer loans on the financial statements. In the first section of the study, the effect of using consumer loans on banks financial statements will be explained. In this section, an example is given to show the practice. In the second section; loans, consumer loans and the loan process is explained. In the third section, the arrangements about loans at banking regulation will be discussed. In the fourth section, Turkish Banking Sector is evaluated on the financial statements and the balance sheet, income statement of the sector will be discussed. In the fifth section, consumer loans are evaluated from different aspects helping of graphics. In this section, there is a trend analysis between December 2004 and March 2010. Keywords: Turkish Banking Sector, Loan, Consumer Loan, Balance Sheet, Income Statement, Real Estate Loan, Automotive Loan, Consumer Loan, Credit Card, Profit

Parathyroid Functions in Thalassemia Major Patients

Background: Hypoparathyroidism is well known to occur in thalassemia major patients, but it is thought to be uncommon and its incidence is considered to be decreasing with improvements in chelation therapy. The objective of this study was to assess the prevalence of parathyroid dysfunction in the first decade of life of the patients with thalassemia major. Patients and Methods: Ninety children with beta-thalassemia major (55 males and 35 females) with a mean age of 7.17±3.78 years (1-13 years) and age and sex matched control group of 60 healthy children (36 males and 24 females) with a mean age 6.98±3.66 years (1-13) years. Serum parathyroid hormone (PTH), serum total Calcium (Ca), serum phosphorus (P), serum alkaline phosphatase (ALP), serum 25-hydroxyvitamin D (25-OHD) and serum ferritin levels were measured. Result: PTH levels were higher than normal range in 23 (25.6%) patients with a mean value of 75.2±31.3 µg/mL compared to those having normal range level (35.3±15.2 µg/mL). Ca levels were found low in 11 patients (12.2%), and P levels were found high in 2 (2.22%) and low in 4 (4.44%) patients while high ALP levels were found in 6 (6.67%) patients. 25-OHD levels were low in all patients with a mean value of 24.95±5.82. Conclusion: Reports in the literature indicate that parathyroid dysfunction due to iron overload generally occurs in 2nd or 3rd decade of patients with thalassemia major. However, our study shows that PTH due to iron overload may develop in a significant number of thalassemia major patients, therefore, all thalassemics should be carefully watched for endocrine organ function such as hyperparathyroidism might occur even in the first decade of the patients with thalassemia major