7 research outputs found

    Diagnostics in Colorectal Surgery

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    The rapid development in radiological examinations has opened a new chapter in colorectal surgery. Unlike classical books, in this section we preferred to use more modern and everyday practical methods such as endoscopy or magnetic resonance imaging or endorectal ultrasonography, rather than sparing less used examinations such as X-rays and barium graphs

    Anatomy of Esophagus

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    Anatomy knowledge is the basic stone of healing diseases. Arteries, veins, wall structure, nerves, narrowing, curves, relations with other organs are very important to understand esophagial diseases. In this chapter we aimed to explain anatomical fundementals of oesophagus

    A RARE PHENOMENON CREATING DILEMMA FOR THE SURGEON:PNEUMOPERITONEUM AFTER COLONOSCOPY

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    Pneumoperitoneum is free air existence in abdomen and usually caused by the perforation in gastrointestinal system. Peptic ulcer disease is the most common cause of perforation and pneumoperitoneum. The presence of free air in abdomen usually indicates emergency surgery. However, surgical approach is not required in some cases of pneumoperitoneum if there is no evidence of perforation and no sign of peritoneal irritation. Herein, we present an 82-year–old male patient who had pneumoperitoneum after colonoscopy and treated non-surgically

    New Horizons in Laparoscopic Surgery

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    Approximately 100 years ago, after the first diagnostic laparoscopy and subsequent developments, the adventure began with laparoscopic appendectomy and cholecystectomy and reached a point where any surgical procedure could be performed easily. Today, many endoscopic surgical procedures have an important role not only in general surgery, but also in the daily practice of many surgical branches. This vertiginous development and change of speed make rapid replacement of the visual and printed materials necessary for training in this area. This book is prepared by surgeons who are very successful in their field

    A comparative analysis of four different surgical methods for treatment of sacrococcygeal pilonidal sinus.

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    Objectives: Although many surgical methods have been described for sacrococcygeal pilonidal sinus treatment, the best option is still controversial. We aimed to compare postoperative outcomes of these different methods in terms of advantages and disadvantages. Methods: The records of 320 patients undergone surgery for primary or recurrent pilonidal sinus between May 2013 and May 2017 were retrospectively analyzed. Demographical data, pre operative stories, wound site infection, seroma development, wound dehiscence, time of healing, duration of return to work, and if there is any recurrence of 303 patients included in the study were recorded. Upon wide local excision, the first surgeon performed marsupialisation and the lay open technique, second surgeon performed vertical excision and primary closure, third surgeon performed Limberg flap transposition and fourth surgeon performed Karydakis' flap transposition. Results: There was no significant difference between the patients in terms of demographical characteristics. The duration of surgery was statistically significantly higher in primary closure method (p = 0.001). The mean duration of return-to-work was statistically significantly lower in primary closure method (p = 0.002). In primary closure method, the recurrence rate was found to be statistically significantly higher than the other methods (p = 0.009). Conclusion: We do not suggest the use of primary closure method in treatment of pilonidal sinus. Because of lower rates of recurrence and shorter durations of return to work, the Karydakis and Limberg methods are seen as safer methods when compared to lay-open and marsupialization method

    Efficacy and safety of trastuzumab emtansine in older patients with HER2-positive advanced breast cancer: a real-world study

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    Introduction: Ado-trastuzumab emtansine (T-DM1) is an antibody-drug conjugate and its survival advantage has been shown in advanced human epidermal growth factor receptor 2 (HER2)-positive breast cancer. However, clinical trials underrepresent patients > 65 years of age, leading to a lack of information in this population. We analyzed the real-world outcomes of older women who were treated with T-DM1 therapy. Methods: We performed a multicenter, observational, retrospective analysis of patients aged > 65 years treated with T-DM1. A total of 93 patients from 10 cancer centers were involved in the study. Our goal was to determine the survival, response rates, and toxicity profile in T-DM1-treated patients, as well as the factors that influence survival. Results: Median follow-up was 12.2 months. Objective response rate was 29%. Median progression-free survival (PFS) and overall survival (OS) were 8.47 and 15.0 months, respectively. In multivariate analysis, Eastern Cooperative Oncology Group Performance Score 2 was found to be an independent prognostic factor for worse PFS (hazard ratio [HR] 1.81, p = 0.032) and OS (HR 2.33, p = 0.006). Any adverse event (AE) was seen in 92.5% of patients; grade 3 or 4 AEs were seen in 30.1%. Dose reduction or treatment discontinuation rates were 11.8% and 6.5%, respectively. Conclusion: The efficacy of T-DM1 was acceptable and it was generally well-tolerated among older patients with advanced HER2-positive breast cancer
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