Outcome of posterior cruciate ligament-retaining primary total knee arthroplasty in arthritic patients

Background: The incidence of arthritis is rising in India due to increase in the proportion of ageing population and obesity. Cruciate retaining total knee arthroplasty (TKA) is a promising mode of treatment for end stage arthritis, with excellent functional outcome. Hence, we have evaluated the functional outcome of posterior cruciate ligament retaining TKA and the problems related to the procedure at our institute.Methods: This prospective study was conducted on 30 patients who underwent posterior cruciate ligament retaining primary TKA at a tertiary health care centre between December 2012 and May 2014. Patients were evaluated using Knee society score (knee score and function score) at regular follow up visits.Results: The study included TKA for 42 knees in 30 patients. Indications for TKA were osteoarthritis in 37 knees and rheumatoid arthritis in 5 knees. The average follow-up period was 24 weeks. All the 42 knees had poor knee score (<60) and poor functional score (<60) preoperatively. Postoperatively 37 knees had excellent (80-100) and 5 knees had good knee score (70-79) whereas 22 patients had excellent (80-100), 5 patients had good (70-79), 2 patients had fair (60-69) and 1 patient had poor functional score (<60). Conclusions: Our study demonstrates that posterior cruciate retaining TKA is a reliable procedure with excellent functional outcome, pain relief and early return of patients to their daily activities. Posterior cruciate retaining TKA provided excellent knee society score and functional score in majority of patients

Opposing Regulation of PROX1 by Interleukin-3 Receptor and NOTCH Directs Differential Host Cell Fate Reprogramming by Kaposi Sarcoma Herpes Virus

Lymphatic endothelial cells (LECs) are differentiated from blood vascular endothelial cells (BECs) during embryogenesis and this physiological cell fate specification is controlled by PROX1, the master regulator for lymphatic development. When Kaposi sarcoma herpes virus (KSHV) infects host cells, it activates the otherwise silenced embryonic endothelial differentiation program and reprograms their cell fates. Interestingly, previous studies demonstrated that KSHV drives BECs to acquire a partial lymphatic phenotype by upregulating PROX1 (forward reprogramming), but stimulates LECs to regain some BEC-signature genes by downregulating PROX1 (reverse reprogramming). Despite the significance of this KSHV-induced bidirectional cell fate reprogramming in KS pathogenesis, its underlying molecular mechanism remains undefined. Here, we report that IL3 receptor alpha (IL3Rα) and NOTCH play integral roles in the host cell type-specific regulation of PROX1 by KSHV. In BECs, KSHV upregulates IL3Rα and phosphorylates STAT5, which binds and activates the PROX1 promoter. In LECs, however, PROX1 was rather downregulated by KSHV-induced NOTCH signal via HEY1, which binds and represses the PROX1 promoter. Moreover, PROX1 was found to be required to maintain HEY1 expression in LECs, establishing a reciprocal regulation between PROX1 and HEY1. Upon co-activation of IL3Rα and NOTCH, PROX1 was upregulated in BECs, but downregulated in LECs. Together, our study provides the molecular mechanism underlying the cell type-specific endothelial fate reprogramming by KSHV

Indium-mediated deoxygenation of amine-N-oxides in aqueous media

Several aromatic and aliphatic amine-N-oxides were deoxygenated to the corresponding amines in good to quantitative yield using indium metal in neutral aqueous media. Other functional groups such as alkenes, halides, esters, ethers, nitriles, amides and sulfones are unaffected under the present reaction conditions

Microwave thermolysis: Part III — A rapid and convenient coupling of 2-naphthols in solvent-free condition^†

2615-2617A rapid and environmentally benign method for the coupling of 2-napthols is described using copper (II) acetonylacetonate under microwave irradiation in dry media. The procedure is very convenient and avoids the use of excess solvent for reaction

A convenient synthesis of benzopyranacetylenes

Knoevenagel products 3 of 3-formylchromone (1) with isoxazol- 5-one 2, after reduction with NaBH<SUB>4</SUB> and exposure to aqueous sodium nitrite/acetic acid and ferrous sulphate gave various benzopyranacetylenes 4 in good yield

Anti Inflammatory Studies of Barringtonia acutangula (Linn) Fruits on Wistar Rats.

The study aims to evaluate the anti inflammatory activity of Barringtonia acutangula (Linn) fruit extracts in wistar rats. In this study fruits of Barringtonia acutangula were extracted with ethanol and purified water, these extracts were subjected to preliminary phytochemical analysis to identify their phytoconstituents. The ethanol and aqueous extracts were evaluated in vivo by using acute inflammatory models like; carrageenan induced paw oedema and chronic models like; cotton-pellet induced granuloma and carrageenan induced air-pouch model in rats. The biochemical parameters like reduced glutathione (GSH), lipid peroxidation and catalase were also estimated as supportive studies. Acute toxicity studies were performed initially in order to ascertain the safety of ethanol and aqueous extracts. The ethanol extract reduced the inflammation more significantly than the aqueous extract in the carrageenan-induced rat paw oedema, cotton-pellet induced granuloma and carrageenan induced air-pouch model in rats. The phytochemical investigation of the ethanol fruit extract showed the presence of phytosterols, glycosides, flavonoids, alkaloids and carbohydrates. From the present study the ethanolic fruit extract of Barringtonia acutangula exhibited the anti-inflammatory effect by augmenting antioxidant defense system in the inflammation bearing rat, which is largely attributable to the additive or synergistic effect of its constituents.

Anti Inflammatory Studies of Barringtonia acutangula (Linn) Fruits on Wistar Rats.

The study aims to evaluate the anti inflammatory activity of Barringtonia acutangula (Linn) fruit extracts in wistar rats. In this study fruits of Barringtonia acutangula were extracted with ethanol and purified water, these extracts were subjected to preliminary phytochemical analysis to identify their phytoconstituents. The ethanol and aqueous extracts were evaluated in vivo by using acute inflammatory models like; carrageenan induced paw oedema and chronic models like; cotton-pellet induced granuloma and carrageenan induced air-pouch model in rats. The biochemical parameters like reduced glutathione (GSH), lipid peroxidation and catalase were also estimated as supportive studies. Acute toxicity studies were performed initially in order to ascertain the safety of ethanol and aqueous extracts. The ethanol extract reduced the inflammation more significantly than the aqueous extract in the carrageenan-induced rat paw oedema, cotton-pellet induced granuloma and carrageenan induced air-pouch model in rats. The phytochemical investigation of the ethanol fruit extract showed the presence of phytosterols, glycosides, flavonoids, alkaloids and carbohydrates. From the present study the ethanolic fruit extract of Barringtonia acutangula exhibited the anti-inflammatory effect by augmenting antioxidant defense system in the inflammation bearing rat, which is largely attributable to the additive or synergistic effect of its constituents.

Prospects for extra-short-duration pigeonpea in Northern Telangana zone of Andhra Pradesh, India.

To identify alternative rainy season crops that fit into the production zone of Northern Telangana, 11 lines of extra-short duration pigeonpeas (ESDP) [Cajanus cajan] which mature in 110-120 days were evaluated at research stations and farmers' fields during 1990-93. Yields ranged from 1.4 to 1.7 t/ha for the lines ICPL85010, ICPL88034 and ICPL84031. A further trial of ICPL85010 and other local crops confirmed that ESDP were the most profitable rainy season crop, and that they fitted into existing cropping systems and avoided Helicoverpa armigera infestation. Prolonged drought during flowering and pod development, pre-harvest sprouting and damage caused by Maruca testulalis [Maruca vitrata] may provide constraints to their adoption

Room Temperature Magnetic Memory Effect in Cluster-Glassy Fe-Doped NiO Nanoparticles

The Fe-doped NiO nanoparticles that were synthesized using a co-precipitation method are characterized by enhanced room-temperature ferromagnetic property evident from magnetic measurements. Neutron powder diffraction experiments suggested an increment of the magnetic moment of 3d ions in the nanoparticles as a function of Fe-concentration. The temperature, time, and field-dependent magnetization measurements show that the effect of Fe-doping in NiO has enhanced the intraparticle interactions due to formed defect clusters. The intraparticle interactions are proposed to bring additional magnetic anisotropy energy barriers that affect the overall magnetic moment relaxation process and emerging as room temperature magnetic memory. The outcome of this study is attractive for the future development of the room temperature ferromagnetic oxide system to facilitate the integration of spintronic devices and understanding of their fundamental physics