Halo-Independent Dark Matter Electron Scattering Analysis with In-Medium Effects

Dark matter (DM)-electron scattering is a prime target of a number of direct DM detection experiments and constitutes a promising avenue for exploring interactions of DM in the sub-GeV mass-range, challenging to probe with nuclear recoils. We extend the recently proposed halo-independent analysis method for DM-electron scattering, which allows to infer the local DM halo properties without any additional assumptions about them, to include in-medium effects through dielectric functions of the target material. We show that in-medium effects could significantly affect halo-independent analysis response functions for germanium and silicon and thus are essential for proper inference of local DM halo characteristics from direct DM detection data.Comment: 9 pages, 5 figure

Silicon slow-light-based photonic mixer for microwave-frequencyconversion applications

This paper was published in OPTICS LETTERS and is made available as an electronic reprint with the permission of OSA. The paper can be found at the following URL on the OSA website: http://dx.doi.org/10.1364/OL.37.001721. Systematic or multiple reproduction or distribution to multiple locations via electronic or other means is prohibited and is subject to penalties under law[EN] We describe and demonstrate experimentally a method for photonic mixing of microwave signals by using a silicon electro-optical Mach¿Zehnder modulator enhanced via slow-light propagation. Slow light with a group index of ~11, achieved in a one-dimensional periodic structure, is exploited to improve the upconversion performance of an input frequency signal from 1 to 10.25 GHz. A minimum transmission point is used to successfully demonstrate the upconversion with very low conversion losses of ~7¿¿dB and excellent quality of the received I/Q modulated QPSK signal with an optimum EVM of ~8%.Financial support from FP7-224312 HELIOS project and Generalitat Valenciana under PROMETEO-2010-087 R&D Excellency Program (NANOMET) are acknowledged. F. Y.Gardes, D. J. Thomson, and G. T. Reed are supported by funding received from the UK EPSRC funding body under the grant “UK Silicon Photonics.” The author A. M. Gutiérrez thanks D. Marpaung for his useful help.Gutiérrez Campo, AM.; Brimont, ACJ.; Herrera Llorente, J.; Aamer, M.; Martí Sendra, J.; Thomson, DJ.; Gardes, FY.... (2012). Silicon slow-light-based photonic mixer for microwave-frequencyconversion applications. Optics Letters. 37(10):1721-1723. https://doi.org/10.1364/OL.37.001721S17211723371

Three-dimensional numerical study of the deep western boundary current in the South China Sea

This study utilized a three-dimensional ocean general circulation model to investigate the intensity, thickness, and width of the three-dimensional deep western boundary current (DWBC) in the South China Sea (SCS). The numerical results show that the DWBC begins near the inlet of the Luzon overflow, flows westward along the northern boundary, proceeds southward along the western boundary, and ultimately terminates at the southern boundary. The mean DWBC’s velocity, thickness, and width is 4.78 cm/s, 1645 m, and 140 km, respectively. Combined with the dynamic results, it is evident that the three-dimensional structure of the DWBC appears to have been visibly weakened after the closure of the deep Luzon overflow. Strong deep mixing has a significantly stronger, thicker, and wider effect on the intensity, thickness, and width of the DWBC. Both the bottom and lateral friction coefficients negatively impact the DWBC in the SCS

Expression of an IKKγ Splice Variant Determines IRF3 and Canonical NF-κB Pathway Utilization in ssRNA Virus Infection

Single stranded RNA (ssRNA) virus infection activates the retinoic acid inducible gene I (RIG-I)- mitochondrial antiviral signaling (MAVS) complex, a complex that coordinates the host innate immune response via the NF-kappaB and IRF3 pathways. Recent work has shown that the IkappaB kinase (IKK)gamma scaffolding protein is the final common adapter protein required by RIG-I.MAVS to activate divergent rate-limiting kinases downstream controlling the NF-kappaB and IRF3 pathways. Previously we discovered a ubiquitous IKKgamma splice-variant, IKKgammaDelta, that exhibits distinct signaling properties.We examined the regulation and function of IKKgamma splice forms in response to ssRNA virus infection, a condition that preferentially induces full length IKKgamma-WT mRNA expression. In IKKgammaDelta-expressing cells, we found increased viral translation and cytopathic effect compared to those expressing full length IKKgamma-WT. IKKgammaDelta fails to support viral-induced IRF3 activation in response to ssRNA infections; consequently type I IFN production and the induction of anti-viral interferon stimulated genes (ISGs) are significantly attenuated. By contrast, ectopic RIG-I.MAVS or TNFalpha-induced canonical NF-kappaB activation is preserved in IKKgammaDelta expressing cells. Increasing relative levels of IKKgamma-WT to IKKgammaDelta (while keeping total IKKgamma constant) results in increased type I IFN expression. Conversely, overexpressing IKKgammaDelta (in a background of constant IKKgamma-WT expression) shows IKKgammaDelta functions as a dominant-negative IRF3 signaling inhibitor. IKKgammaDelta binds both IKK-alpha and beta, but not TANK and IKKepsilon, indicating that exon 5 encodes an essential TANK binding domain. Finally, IKKgammaDelta displaces IKKgammaWT from MAVS explaining its domainant negative effect.Relative endogenous IKKgammaDelta expression affects cellular selection of inflammatory/anti-viral pathway responses to ssRNA viral infection

Southward key pathways of radioactive materials from the Fukushima Daiichi Nuclear Power Plant

This study examines the interannual and seasonal variations in the distribution of radioactive materials released from the Fukushima Daiichi Nuclear Power Plant (FDNPP) accident in the surface layer of the Kuroshio Extension (KE). Focusing on the contrasting flow conditions in 2015 (southward) and 2021 (northward) – significant oscillatory phases of the KE’s mean flow axis – the research analyzes the impact of seasonal variations on particle transport pathways. The findings reveal distinct seasonal patterns: summer releases primarily follow the eastward KE movement, while winter releases exhibit a southward trajectory. The study further quantifies the transport timescales, demonstrating that particles can reach the Luzon Strait within 10 months, subsequently diverging northward along the Kuroshio and northwestward along the Kuroshio Branch Current, potentially entering the South China Sea within 13 months. This research contributes valuable insights into the seasonal dynamics governing the dispersion and transport of Fukushima-derived radioisotopes in the surface ocean, highlighting the crucial role of the KE in influencing their trajectories

Lenvatinib improves anti-PD-1 therapeutic efficacy by promoting vascular normalization via the NRP-1-PDGFRβ complex in hepatocellular carcinoma

IntroductionThe limited response to immune checkpoint blockades (ICBs) in patients with hepatocellular carcinoma (HCC) highlights the urgent need for broadening the scope of current immunotherapy approaches. Lenvatinib has been shown a potential synergistic effect with ICBs. This study investigated the optimal method for combining these two therapeutic agents and the underlying mechanisms.MethodsThe effect of lenvatinib at three different doses on promoting tissue perfusion and vascular normalization was evaluated in both immunodeficient and immunocompetent mouse models. The underlying mechanisms were investigated by analyzing the vascular morphology of endothelial cells and pericytes. The enhanced immune infiltration of optimal-dose lenvatinib and its synergistic effect of lenvatinib and anti-PD-1 antibody was further evaluated by flow cytometry and immunofluorescence imaging.ResultsThere was an optimal dose that superiorly normalized tumor vasculature and increased immune cell infiltration in both immunodeficient and immunocompetent mouse models. An adequate concentration of lenvatinib strengthened the integrity of human umbilical vein endothelial cells by inducing the formation of the NRP-1-PDGFRβ complex and activating the Crkl-C3G-Rap1 signaling pathway in endothelial cells. Additionally, it promoted the interaction between endothelial cells and pericytes by inducing tyrosine-phosphorylation in pericytes. Furthermore, the combination of an optimal dose of lenvatinib and an anti-PD-1 antibody robustly suppressed tumor growth.ConclusionsOur study proposes a mechanism that explains how the optimal dose of lenvatinib induces vascular normalization and confirms its enhanced synergistic effect with ICBs

The Power in Being Yourself: The Experience of Authenticity Enhances Power

Recent research indicates that power breeds authenticity, suggesting that people associate power with behaving authentically. Extending this notion, we hypothesized that the converse is also true—that the experience of authenticity enhances power. Five experiments (total N = 703) yielded support for this hypothesis. Specifically, participants who recalled an authentic, versus inauthentic, experience reported greater state power (Studies 1-3). Studies 2 and 3 showed further that this authenticity-to-power link was mediated by a reduced fear of rejection for expressing one’s true self. Fear of rejection was manipulated in Study 4 to document the causal impact of a reduced fear of rejection on feelings of power. Finally, Study 5 extended the prior studies into the realm of social perception, demonstrating that people infer others’ power from their acts of authenticity. Our findings could not be explained by pre-existing power differences that may have led to the authentic or inauthentic behavior in the first place (Studies 1, 2, & 5), nor by authenticity eliciting positive affect (Studies 3 & 5). Implications for the maintenance of power hierarchies, and the use of authenticity as a strategic means through which power can be obtained, are discussed