Putative avocado toxicity in two dogs

Two dogs were seen at the University Veterinary Teaching Hospital, Nairobi, Kenya, both having histories of dyspnoea, progressively enlarging abdomens, anasarca, ascites, pleural and pericardial effusion, and pulmonary oedema. One of the dogs had a mild neutrophilic leucocytosis, elevated levels of alkaline phosphatase, alanine aminotransferase, lactate dehydrogenase and proteinuria. Histopathological examination of the myocardium revealed some damage to myocytes and a mononuclear cellular infiltration involving the myocardium, liver and kidneys. The two dogs had a fondness for avocado fruits and, as the presenting syndrome is identical to that seen in goats, sheep and horses poisoned by avocados, a comparison is made and the probable manifestation of this poisoning presented.The articles have been scanned in colour with a HP Scanjet 5590; 600dpi. Adobe Acrobat XI Pro was used to OCR the text and also for the merging and conversion to the final presentation PDF-format.mn201

The epidemiology of gastrointestinal nematodes in goats in the low potential areas of Thika District, Kenya

EPIDEMIOLOGIE DES NEMATODES GASTRO-INTESTINAUX CHEZ LES CHEVRES DANS LES ZONES A FAIBLES POTENTIALITES DU DISTRICT DE THIKA Résumé La prévalence et l'intensité des infections par les nématodes gastro-intestinaux chez les chèvres dans quatre petites fermes (< 5ha avec moins de 30 chèvres) dans les zones à faibles potentialités du district de Thika au Kenya, ont fait l'objet d'études pendant un an. La prévalence et l'intensité des infections variaient selon les fermes et les conditions atmosphériques. Les différences relatives aux groupes d'âge étaient notables uniquement pendant la saison sèche lorsque le nombre d'oeufs de nématodes par gramme de fèces était plus élevé chez les chevreaux que chez les jeunes et les adultes. Le nombre d'oeufs de nématodes dans les fèces augmentait pendant les longues pluies (avril-juin) et durant les courtes et fortes pluies vers la fin de la période d'étude (novembre-février). Des traitements anthelminthiques ont été administrés à toutes les chèvres dans les fermes en fonction du nombre d'oeufs de nématodes dans les fèces. Quatre traitements ont été donnés pendant la saison des pluies et un traitement à la fin de la saison sèche en septembre, et il s'ensuivait une réduction du nombre d'oeufs de nématodes dans les fèces. Haemonchus contortus était le principal nématode recueilli des coprocultures. Il a été conclu que la prévalence et l'intensité des infections par les helminthes gastro-intestinaux chez les chèvres dans cette région variaient avec les saisons et que Haemonchus contortus était le principal nématode qui infectait les chèvres. Summary The prevalence and intensity of gastrointestinal nematode infections in goats in four small scale farms (< 5ha each with less than 30 goats) in the low potential areas of Thika District, Kenya, was studied over a period of one year. The prevalence and intensity of infection varied with the farms and the weather conditions. The differences in the age groups were observed only during the dry season when the kids had higher eggs per gram of faeces (EPG's) than the young and the adults. There was a rise in faecal egg counts during the long rains (April - June) and during the heavy short rains experienced towards the end of the study period (November - February). Anthelmintic treatments were given to all the goats on the farms depending on the level of the faecal egg counts. Four treatments were given during the rainy season (months) and one at the end of the dry season in September. These treatments were followed by reduced faecal egg counts. Haemonchus contortus was the main nematode recovered from coprocultures. It was concluded that the prevalence and intensity of gastrointestinal helminth infection in goats in this area varied with seasons and that H. contortus was the main nematode infecting the goats. Bull Anim. Hlth. Prod. Afr. (2004) 53,5-1

A systematic review of Rift Valley fever epidemiology 1931-2014

Background: Rift Valley Fever (RVF) is a mosquito-borne viral zoonosis that was first isolated and characterized in 1931 in Kenya. RVF outbreaks have resulted in significant losses through human illness and deaths, high livestock abortions and deaths. This report provides an overview on epidemiology of RVF including ecology, molecular diversity spatiotemporal analysis, and predictive risk modeling. Methodology: Using the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines, we systematically searched for relevant RVF publications in repositories of the World Health Organization Library and Information Networks for Knowledge (WHOLIS), U.S Centers for Disease Control and Prevention (CDC), and Food and Agricultural Organization (FAO). Detailed searches were performed in Google Scholar, SpringerLink, and PubMed databases and included conference proceedings and books published from 1931 up to 31st January 2015. Results and discussion: A total of 84 studies were included in this review; majority (50%) reported on common human and animal risk factors that included consumption of animal products, contact with infected animals and residing in low altitude areas associated with favorable climatic and ecological conditions for vector emergence. A total of 14 (16%) of the publications described RVF progressive spatial and temporal distribution and the use of risk modeling for timely prediction of imminent outbreaks. Using distribution maps, we illustrated the gradual spread and geographical extent of disease; we also estimated the disease burden using aggregate human mortalities and cumulative outbreak periods for endemic regions. Conclusion: This review outlines common risk factors for RVF infections over wider geographical areas; it also emphasizes the role of spatial models in predicting RVF enzootics. It, therefore, explains RVF epidemiological status that may be used for design of targeted surveillance and control programs in endemic countries

Comparison of knowledge, attitude, and practices of animal and human brucellosis between nomadic pastoralists and non-pastoralists in Kenya

Background The seroprevalence of brucellosis among nomadic pastoralists and their livestock in arid lands is reported to be over10-fold higher than non-pastoralists farmers and their livestock in Kenya. Here, we compared the seroprevalence of nomadic pastoralists and mixed farming with their knowledge of the disease and high-risk practices associated with brucellosis infection. Methods Across-sectional study was conducted in two counties - Kiambu County where farmers primarily practice smallholder livestock production and crop farming, and Marsabit County where farmers practice nomadic pastoral livestock production. Stratified random sampling was applied, in which sublocations were initially selected based on predominant livestock production system, before selecting households using randomly generated geographical coordinates. In each household, up to three persons aged 5 years and above were randomly selected, consented, and tested for Brucella spp IgG antibodies. A structured questionnaire was administered to the household head and selected individuals on disease knowledge and risky practices among the pastoralists and mixed farmers compared. Multivariable mixed effects logistic regression model was used to assess independent practices associated with human Brucella spp. IgG seropositivity. Results While the majority (74%) of pastoralist households had little to no formal education when compared to mixed (8%), over 70% of all households (pastoralists and mixed farmers) had heard of brucellosis and mentioned its clinical presentation in humans. However, fewer than 30% of all participants (pastoralists and mixed farmers) knew how brucellosis is transmitted between animals and humans or how its transmission can be prevented. Despite their comparable knowledge, significantly more seropositive pastoralists compared to mixed farmers engaged in risky practices including consuming unboiled milk (79.5% vs 1.7%, p < 0.001) and raw blood (28.3% vs 0.4%, p < 0.001), assisting in animal birth (43.0% vs 9.3%, p < 0.001), and handling raw hides (30.6% vs 5.5%, p < 0.001)., Conclusion Nomadic pastoralists are more likely to engage in risky practices that promote Brucella Infection, probably because of their occupation and culture, despite having significant knowledge of the disease

Enhanced surveillance for Rift Valley fever in livestock during El Niño rains and threat of RVF outbreak, Kenya, 2015-2016

Background In mid-2015, the United States’ Pandemic Prediction and Forecasting Science and Technical Working Group of the National Science and Technology Council, Food and Agriculture Organization Emergency Prevention Systems, and Kenya Meteorological Department issued an alert predicting a high possibility of El-Niño rainfall and Rift Valley Fever (RVF) epidemic in Eastern Africa. Methodology/Principal findings In response to the alert, the Kenya Directorate of Veterinary Services (KDVS) carried out an enhanced syndromic surveillance system between November 2015 and February 2016, targeting 22 RVF high-risk counties in the country as identified previously through risk mapping. The surveillance collected data on RVF-associated syndromes in cattle, sheep, goats, and camels from >1100 farmers through 66 surveillance officers. During the 14-week surveillance period, the KDVS received 10,958 reports from participating farmers and surveillance officers, of which 362 (3.3%) had at least one syndrome. The reported syndromes included 196 (54.1%) deaths in young livestock, 133 (36.7%) abortions, and 33 (9.1%) hemorrhagic diseases, with most occurring in November and December, the period of heaviest rainfall. Of the 69 herds that met the suspect RVF herd definition (abortion in flooded area), 24 (34.8%) were defined as probable (abortions, mortalities in the young ones, and/or hemorrhagic signs) but none were confirmed. Conclusion/Significance This surveillance activity served as an early warning system that could detect RVF disease in animals before spillover to humans. It was also an excellent pilot for designing and implementing syndromic surveillance in animals in the country, which is now being rolled out using a mobile phone-based data reporting technology as part of the global health security system