Analysis of Dynamic Mode Decomposition

In this master thesis, a study was conducted on a method known as Dynamic mode decomposition(DMD), an equation-free technique which does not require to know the underlying governing equations of the complex data. As a result of massive datasets from various resources, like experiments, simulation, historical records, etc. has led to an increasing demand for an efficient method for data mining and analysis techniques. The main goals of data mining are the description and prediction. Description involves finding patterns in the data and prediction involves predicting the system dynamics. An important aspect when analyzing an algorithm is testing. In this work, DMD-a data based technique is used to test different cases to find the underlying patterns, predict the system dynamics and for reconstruction of original data. Using real data for analyzing a new algorithm may not be appropriate due to lack of knowledge of the algorithm performance in various cases. So, testing is done on synthetic data for all the cases discussed in this work, as it is useful for visualization and to find the robustness of the new algorithm. Finally, this work makes an attempts to understand the DMD\u27s performance and limitations better for the future applications with real data

A Study on the Impact of International Financial Reporting Standards Convergence on Indian Corporate Sector

In the present era of globalization, more than 3600 multinational companies are establishing their businesses in the different sectors in India. These Indian business firms are presenting financial statements as per IFRSs, Indian GAAPs, USGAAPs, Japan GAAP, etc., With a view to avoid this kind of inconvenience

Recent Trends in E- Banking

Rapid changes that occur in banking and IT, in particular, in recent years, have revolutionized the way in which the banks deliver services and products to the clients. All the banks try to come up with solutions as fast as possible in order to help customers in conducting their activities. E-banking has some special characteristics resulted in changing risks consideration of traditional banking activities. This paper mainly focuses on Development of e-banking, Role of RBI on E-banking, Problems of e-banking, recent trends in e-banking and impact of e-banking have been analyzed. It concludes that Fundamentals of banking/e-banking may remain same, but the manner in which we receive/perceive “the value” is undergone a sea change where IT enabled services is affectively used

Design, Development and Invitro Evaluation of Bilayer Tablets of Loratidine (IR) and Phenylephrine (SR)

The present study was carried out to develop the Bilayer tablets of Phenylephrine as sustained release and Loratidine as immediate release component. Phenylephrine is a selective α1-adrenergic receptor agonist of the Phenylephrine class used primarily as a decongestant, as an agent to dilate the pupil, and to increase blood pressure. Loratadine is a second-generation peripheral histamine H1-receptor blocker used to treat allergies. In the present study the bilayer tablets of Phenylephrine (SR) and Loratidine (IR) was formulated and evaluated, percentage friability for all the formulations was below 1% indicating that the friability was within the range of standard specification. All the formulations showed post-compression parameters i.e. friability and drug content were within acceptable official IP limits. Various sustained release formulations were formulated with super disintegrant, polymer alone; and microcrystalline cellulose was used as diluents. The tablets were evaluated for Pharmacopeial and non-Pharmacopeial (industry specified) tests. Based on the results, F-8, F-4 were identified as better formulation amongst all formulations

Establishment of reverse genetics system for PPR virus to develop recombinant vaccines

Across the developing world peste des petits ruminants virus (PPRV) places a huge disease burden on small ruminant agriculture. PPR is mainly controlled by vaccinating animals with live attenuated vaccines. However, the current PPR vaccines and companion serological tests do not enable serological differentiation between naturally infected and vaccinated animals (DIVA), therefore a meaningful serological assessment of vaccine coverage and epidemiological surveillance is not possible. Therefore, the main objective of this PhD study was to establish a reverse genetics system for PPRV, so that a marker vaccine could be developed to enable the serological differentiation between vaccination and infection, alongside developing proof of concept for increasing the valency of the existing vaccines. Initially, as a prerequisite to full genome synthesis the full genome sequence for a PPRV vaccine strain was confirmed. An efficient reverse genetics system for the PPRV Nigeria75/1 vaccine strain was established in this study and 3 recombinant PPRVs were rescued including a faithful clone of the vaccine strain (rPPRV Nigeria75/1), a clone expressing GFP as a heterologous protein (rPPRV+GFP Nigeria75/1) and a negatively marked vaccine containing mutations to the haemagglutinin (H) gene (rPPRV-C77 Nigeria75/1). All 3 rescued viruses showed similar growth characteristics in vitro when compared to the parental vaccine strain and, following in vivo assessment the H mutant provided full protection in goats upon virulent virus challenge. Although the mutations made to H abrogated in vitro binding of C77, the mutations made were not sufficient to enable DIVA in vivo. Finally proof of concept was developed for the segmentation of PPRV and expression of heterologous proteins in an effort to generate a multivalent vaccine. A recombinant two-segmented version of PPRV was successfully rescued that expressed GFP from one segment and the bluetongue virus VP2 from the other. This virus was partially characterised in vitro and demonstrates the potential for this approach in the development of multivalent vaccines for small ruminants

Spillover of Peste des Petits Ruminants Virus from Domestic to Wild Ruminants in the Serengeti Ecosystem, Tanzania

We tested wildlife inhabiting areas near domestic livestock, pastures, and water sources in the Ngorongoro district in the Serengeti ecosystem of northern Tanzania and found 63% seropositivity for peste des petits ruminants virus. Sequencing of the viral genome from sick sheep in the area confirmed lineage II virus circulation

Suppression of DC-SIGN and gH Reveals Complex, Subset-Specific Mechanisms for KSHV Entry in Primary B Lymphocytes

Kaposi sarcoma-associated herpesvirus (KSHV) is the causative agent of multiple cancers in immunocompromised patients including two lymphoproliferative disorders associated with KSHV infection of B lymphocytes. Despite many years of research into the pathogenesis of KSHV associated diseases, basic questions related to KSHV molecular virology remain unresolved. One such unresolved question is the cellular receptors and viral glycoproteins needed for KSHV entry into primary B lymphocytes. In this study, we assess the contributions of KSHV glycoprotein H (gH) and the cellular receptor DC-SIGN to KSHV infection in tonsil-derived B lymphocytes. Our results show that (1) neither KSHV-gH nor DC-SIGN are essential for entry into any B cell subset, (2) DC-SIGN does play a role in KSHV entry into tonsil-derived B cells, but in all B cell subtypes alternative entry mechanisms exist, (3) KSHV-gH can participate in KSHV entry into centrocytes via a DC-SIGN independent entry mechanism, and (4) in the absence of KSHV-gH, DC-SIGN is required for KSHV entry into centrocytes. Our results provide a first glimpse into the complexity of KSHV entry in the lymphocyte compartment and highlight that multiple subset-dependent entry mechanisms are employed by KSHV which depend upon multiple cellular receptors and multiple KSHV glycoproteins