241 research outputs found
Recommended from our members
The use of platelet-rich plasma in treatment of olfactory dysfunction: A pilot study.
BackgroundOlfactory dysfunction is a prevalent problem with a significant impact on quality of life and increased mortality. Limited effective therapies exist. Platelet-rich plasma (PRP) is an autologous biologic product with anti-inflammatory and neuroprotective effects. This novel pilot study evaluated the role of PRP on olfactory neuroregeneration in patients with hyposmia.MethodsSeven patients who had olfactory loss greater than 6āmonths in duration, no evidence of sinonasal inflammatory disease, and no improvement with olfactory training and budesonide topical rinses were enrolled in this preliminary study. Patients received a single intranasal injection of PRP into the mucosa of the olfactory cleft. The Sniffin' Sticks olfactory test consisting of threshold, discrimination, and identification measurements (TDI) was administered at the beginning of the study and at 1 and 3āmonths.ResultsAll patients reported a subjective improvement of their smell shortly after injection but then stabilized. At 3-month post-treatment, two patients with functional anosmia (TDIā<ā16) did not improve significantly. Five patients with hyposmia (TDIā>ā16 but <30) showed an improvement with 60% achieving normosmia (TDIā>ā30) at 3-month follow-up. On average, patients with baseline TDIā>ā16 improved by 5.85 points with the most significant improvement in the threshold subcomponent. There were no adverse outcomes from intranasal PRP injections.ConclusionPRP appears safe for use in the treatment of olfactory loss, and preliminary data suggest possible efficacy, especially for those with moderate yet persistent loss. Further studies will help determine optimal frequency and duration of use.Level of evidence 2
From Molecular Cores to Planet-forming Disks: An SIRTF Legacy Program
Crucial steps in the formation of stars and planets can be studied only at midā to farāinfrared wavelengths, where the Space Infrared Telescope (SIRTF) provides an unprecedented improvement in sensitivity. We will use all three SIRTF instruments (Infrared Array Camera [IRAC], Multiband Imaging Photometer for SIRTF [MIPS], and Infrared Spectrograph [IRS]) to observe sources that span the evolutionary sequence from molecular cores to protoplanetary disks, encompassing a wide range of cloud masses, stellar masses, and starāforming environments. In addition to targeting about 150 known compact cores, we will survey with IRAC and MIPS (3.6ā70 Ī¼m) the entire areas of five of the nearest large molecular clouds for new candidate protostars and substellar objects as faint as 0.001 solar luminosities. We will also observe with IRAC and MIPS about 190 systems likely to be in the early stages of planetary system formation (ages up to about 10 Myr), probing the evolution of the circumstellar dust, the raw material for planetary cores. Candidate planetāforming disks as small as 0.1 lunar masses will be detectable. Spectroscopy with IRS of new objects found in the surveys and of a select group of known objects will add vital information on the changing chemical and physical conditions in the disks and envelopes. The resulting data products will include catalogs of thousands of previously unknown sources, multiwavelength maps of about 20 deg^2 of molecular clouds, photometry of about 190 known young stars, spectra of at least 170 sources, ancillary data from groundābased telescopes, and new tools for analysis and modeling. These products will constitute the foundations for many followāup studies with groundābased telescopes, as well as with SIRTF itself and other space missions such as SIM, JWST, Herschel, and TPF/Darwin
The Spitzer c2d Survey of Large, Nearby, Interstellar Clouds. VIII. Serpens Observed with MIPS
We present maps of 1.5 deg^2 of the Serpens dark cloud at 24, 70, and 160 Ī¼m observed with the Spitzer Space Telescope MIPS camera. We describe the observations and briefly discuss the data processing carried out by the c2d team on these data. More than 2400 compact sources have been extracted at 24 Ī¼m, nearly 100 at 70 Ī¼m, and four at 160 Ī¼m. We estimate completeness limits for our 24 Ī¼m survey from Monte Carlo tests with artificial sources inserted into the Spitzer maps. We compare source counts, colors, and magnitudes in the Serpens cloud to two reference data sets: a 0.50 deg^2 set on a low-extinction region near the dark cloud, and a 5.3 deg^2 subset of the SWIRE ELAIS N1 data that was processed through our pipeline. These results show that there is an easily identifiable population of young stellar object candidates in the Serpens cloud that is not present in either of the reference data sets. We also show a comparison of visual extinction and cool dust emission illustrating a close correlation between the two and find that the most embedded YSO candidates are located in the areas of highest visual extinction
The Spitzer c2d survey of Large, Nearby, Interstellar Clouds. V. Chamaeleon II Observed with IRAC
We present IRAC (3.6, 4.5, 5.8, and 8.0 micron) observations of the
Chamaeleon II molecular cloud. The observed area covers about 1 square degree
defined by . Analysis of the data in the 2005 c2d catalogs reveals a
small number of sources (40) with properties similar to those of young
stellaror substellar objects (YSOs). The surface density of these YSO
candidates is low, and contamination by background galaxies appears to be
substantial, especially for sources classified as Class I or flat SED. We
discuss this problem in some detail and conclude that very few of the candidate
YSOs in early evolutionary stages are actually in the Cha II cloud. Using a
refined set of criteria, we define a smaller, but more reliable, set of 24 YSO
candidates.Comment: 19 pages, 10 figures, in press Ap
The science case and mission concept for the Single Aperture Far-Infrared (SAFIR) Observatory
SAFIR is a large (10 m-class), cold (4-10 K) space telescope for wavelengths between 20 microns and 1 mm. It will provide sensitivity a factor of a hundred or more greater than that of Spitzer and Herschel, leveraging their capabilities and building on their scientific legacies. Covering this scientifically critical wavelength regime, it will complement the expected wavelength performance of the future flagship endeavors JWST and ALMA. This vision mission will probe the origin of stars and galaxies in the early universe, and explore the formation of solar systems around nearby young stars. Endorsed as a priority by the Decadal Study and successive OSS roadmaps, SAFIR represents a huge science need that is matched by promising and innovative technologies that will allow us to satisfy it. In exercising those technologies it will create the path for future infrared missions. This paper reviews the scientific goals of the mission and promising approaches for its architecture, and considers remaining technological hurdles. We review how SAFIR responds to the scientific challenges in the OSS Strategic Plan, and how the observatory can be brought within technological reach
The Spitzer c2d Survey of Large, Nearby, Interstellar Clouds. VII. Ophiuchus Observed with MIPS
We present maps of 14.4 deg^2 of the Ophiuchus dark clouds observed by the Spitzer Space Telescope Multiband Imaging Photometer for Spitzer (MIPS). These high-quality maps depict both numerous point sources and extended dust emission within the star-forming and nonāstar-forming portions of these clouds. Using PSF-fitting photometry, we detect 5779 sources at 24 Ī¼m and 81 sources at 70 Ī¼m at the 10 Ļ level of significance. Three hundred twenty-three candidate young stellar objects (YSOs) were identified according to their positions on the MIPS/2MASS K versus color-magnitude diagrams, as compared to 24 Ī¼m detections in the SWIRE extragalactic survey. We find that more than half of the YSO candidates, and almost all those with protostellar Class I spectral energy distributions, are confined to the known cluster and aggregates
The Spitzer c2d Survey of Weak-line T Tauri Stars II: New Constraints on the Timescale for Planet Building
One of the central goals of the Spitzer Legacy Project ``From Molecular Cores
to Planet-forming Disks'' (c2d) is to determine the frequency of remnant
circumstellar disks around weak-line T Tauri stars (wTTs) and to study the
properties and evolutionary status of these disks. Here we present a census of
disks for a sample of over 230 spectroscopically identified wTTs located in the
c2d IRAC (3.6, 4.5, 4.8, and 8.0 um) and MIPS (24 um) maps of the Ophiuchus,
Lupus, and Perseus Molecular Clouds. We find that ~20% of the wTTs in a
magnitude limited subsample have noticeable IR-excesses at IRAC wavelengths
indicating the presence of a circumstellar disk. The disk frequencies we find
in these 3 regions are ~3-6 times larger than that recently found for a sample
of 83 relatively isolated wTTs located, for the most part, outside the highest
extinction regions covered by the c2d IRAC and MIPS maps. The disk fractions we
find are more consistent with those obtained in recent Spitzer studies of wTTs
in young clusters such as IC 348 and Tr 37. From their location in the H-R
diagram, we find that, in our sample, the wTTs with excesses are among the
younger part of the age distribution. Still, up to ~50% of the apparently
youngest stars in the sample show no evidence of IR excess, suggesting that the
circumstellar disks of a sizable fraction of pre-main-sequence stars dissipate
in a timescale of ~1 Myr. We also find that none of the stars in our sample
apparently older than ~10 Myrs have detectable circumstellar disks at
wavelengths < 24 um. Also, we find that the wTTs disks in our sample exhibit a
wide range of properties (SED morphology, inner radius, L_DISK/L*, etc) which
bridge the gaps observed between the cTTs and the debris disk regimes.Comment: 54 pages, 13 figures, Accepted by Ap
- ā¦