Pengembangan Media Pembelajaran Fisika Berupa Buletin Dalam Bentuk Buku Saku Untuk Pembelajaran Fisikakelas VIII Materi Gaya Ditinjau Dari Minat Baca Siswa

Tujuan dari penelitian ini untuk mengembangkan media pembelajaran berupa buletin dalam bentuk buku saku untuk pembelajaran Fisika kelas VIII pada materi Gaya ditinjau dari aspek materi, konstruk, dan bahasa serta minat baca siswa. Penelitian ini termasuk penelitian pengembangan yang menggunakan metode Research and Development (R&D). Penelitian ini menggunakan model pengembangan model prosedural yaitu model yang bersifat deskriptif yang menunjukkan tahapan-tahapan yang harus diikuti untuk menghasilkan produk berupa media pembelajaran.Jenis data yang diperoleh bersifat kualitatif dan kuantitatif yaitu angket dan wawancara. Teknik analisis data yang digunakan adalah analisis deskriptif kualitatif dan kuantitatif. Hasil penelitian menunjukkan bahwa media pembelajaran yang dikembangkan berupa buletin Fisika dalam bentuk buku saku memiliki kriteria sangat baik berdasarkan penilaian dari ahli materi, ahli bahasa Indonesia, dan ahli media memberikan rata-rata penilaian sebesar 86,56%. Media pembelajaran yang dikembangkan juga memiliki kriteria sangat baik bila ditinjau dari peningkatan minat baca siswa. Hal ini terbukti pada hasil angket minat baca awal dan akhir yang diberikan kepada siswa yang memberikan rata-rata peningkatan sebesar 11,13%. Selain itu juga dianalisis dengan menggunakan uji-t berpasangan terhadap data masing-masing kelompok uji coba untuk mengetahui signifikansi dari peningkatan minat baca siswa. Untuk uji coba perorangan diperoleh hasil perhitungan thitung = 6,957 > ttabel = 1,943 dan nilai Sig. = 0,001 < 0,05 yang berarti sangat signifikan. Untuk kelompok kecil didapatkan hasil perhitungan bahwa thitung = 7,848 > ttabel = 1,725 dan nilai Sig. = 0,000 < 0,05 yang berarti sangat signifikan. Untuk kelompok besar juga didapatkan hasil perhitungan bahwa thitung = 20,214 > ttabel = 1,725 dan nilai Sig. = 0,000 < 0,05 yang berarti sangat signifikan. Simpulan dari penelitian ini adalah media pembelajaran berupa buletin dalam bentuk buku saku memiliki kriteria sangat baik bila ditinjau dari aspek materi, konstruk, dan bahasa serta minat baca siswa

Comparison of micro-radiofrequency therapy and tolterodine for the treatment of newly diagnosed overactive bladder: A retrospective cohort study

PurposeThis study aimed to retrospectively compare the efficacy and safety of micro-radiofrequency (RF) therapy through the urethra vs. oral tolterodine tartrate in the treatment of newly diagnosed overactive bladder (OAB).Materials and methodsIn this study, 46 patients who were newly diagnosed with moderate-to-severe OAB were included; 23 of them underwent the micro-RF treatment procedure, and the other 23 patients took tolterodine. Bladder diaries were recorded 3 days before treatment and during the follow-up period on 1, 3, and 7 weeks after micro-RF therapy or oral tolterodine. Micturition parameters including daily voiding times, daily urge urinary incontinence (UI) episodes, daily urgency episodes, mean volume per micturition, post-void residual volume (PVR), maximum urine flow rate (Qmax), overactive bladder symptom score (OABSS), and quality of life (QoL) score were analyzed.ResultsAll 46 patients underwent either micro-RF or oral tolterodine treatment, as well as a complete follow-up. The incidence of adverse events in the micro-RF group was 8.7% (2/23), and that in the tolterodine group was 43.5% (10/23). The following two adverse events happened in the micro-RF group: an injury to the urethra during catheterization in a man and a urinary tract infection in a woman, both of which were relieved or disappeared after day 3. The adverse effects in the tolterodine group were mainly dry mouth (4/23), dysuria (5/23), and constipation (8/23), but none of the patients withdrew from the drug therapy. Compared to pre-therapy, all parameters of both groups, including daily voiding times, daily urgency episodes, mean volume per micturition, OABSS, and QoL score, demonstrated significant improvements during follow-up in 7 weeks after therapy, except for daily UI episodes in the tolterodine group, while the above parameters showed bigger improvements in the micro-RF group than in the tolterodine group. Besides, the general treatment efficacy of micro-RF was 73.9% (17/23), which was significantly better than tolterodine (10/23, 43.5%), and the difference was 30.4% [95% CI: 3.4–57.5%, p = 0.036].ConclusionIn this retrospective study, we found that micro-RF therapy is safe and more effective than oral tolterodine for newly diagnosed moderate-to-severe OAB in a short-term follow-up. Stronger evidence would be provided through a well-designed, prospective, randomized controlled trial

CYP2A6 activity and cigarette consumption interact in smoking-related lung cancer susceptibility.

Cigarette smoke, containing both nicotine and carcinogens, causes lung cancer. However, not all smokers develop lung cancer, highlighting the importance of the interaction between host susceptibility and environmental exposure in tumorigenesis. Here, we aimed to delineate the interaction between metabolizing ability of tobacco carcinogens and smoking intensity in mediating genetic susceptibility to smoking-related lung tumorigenesis. Single-variant and gene-based associations of 43 tobacco carcinogen-metabolizing genes with lung cancer were analyzed using summary statistics and individual-level genetic data, followed by causal inference of Mendelian randomization, mediation analysis, and structural equation modeling. Cigarette smoke-exposed cell models were used to detect gene expression patterns in relation to specific alleles. Data from the International Lung Cancer Consortium (29,266 cases and 56,450 controls) and UK Biobank (2,155 cases and 376,329 controls) indicated that the genetic variant rs56113850 C>T located in intron 4 of CYP2A6 was significantly associated with decreased lung cancer risk among smokers [odds ratio (OR) = 0.88, 95% confidence interval = 0.85-0.91, P = 2.18×10-16], which might interact (Pinteraction = 0.028) with and partially be mediated (ORindirect = 0.987) by smoking status. Smoking intensity accounted for 82.3% of the effect of CYP2A6 activity on lung cancer risk but entirely mediated the genetic effect of rs56113850. Mechanistically, the rs56113850 T allele rescued the downregulation of CYP2A6 caused by cigarette smoke exposure, potentially through preferential recruitment of transcription factor HLTF. Together, this study provides additional insights into the interplay between host susceptibility and carcinogen exposure in smoking-related lung tumorigenesis

Efficacy of Ahmed Glaucoma Valve Implantation on Neovascular Glaucoma

To evaluate the efficacy of Ahmed glaucoma valve (AGV) implantation in treating neovascular glaucoma (NVG) and analyze the factors influencing the surgical success rate, a retrospective investigation of 59 NVG patients (66 eyes) who underwent AGV implantation was conducted at Jiangsu Province Hospital, China, from January 2014 to June 2018. Intraocular pressure (IOP), visual acuity, surgical success rates, medications, and complications were monitored at post-operative 1 day, 1 week, 1, 3, 6 and 12 months. Surgical success criteria were defined as 6 mm Hg < IOP < 21 mmHg with or without additional medications. Results showed average IOP was statistically significant between pre-operative visit and each follow-up visit (all P<0.05). At 12 months, the success rate was 66.7%. Multiple stepwise regression analysis suggested that age, panretinal photocoagulation (PRP), complications and hyphema were significant factors influencing the surgical success rate (all P<0.05). Thus, we conclude that AGV implantation is effective and safe for treatment of NVG. Surgical success is dependent on age, PRP, complications, and hyphema.Open access journalThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]

Advances in microresonator-based frequency comb generation

Microresonator-besed frequency combs have attracted intense interests recently for their promising applications in integrated miniature optical clocks, low-noise microwave sources, and femtosecond pulse generators. The compact, chip-scale integratable high-Q microresonators permit precisely-spaced sharp spectral comb lines in the range of a few gigahertz to over terahertz with continuouswave pump. Here we introduce our latest research progresses on Kerr frequency comb techniques and present an outlook of their future developments &amp; application

Mode Splitter Without Changing the Mode Order in SOI Waveguide

<p> We proposed a mode splitter based on directional coupler (DC), which is capable of splitting the TE0 and TE1 modes without changing the mode order. It is found that high coupling efficiency (higher than -1 dB), low mode crosstalk (less than -16 dB), wide bandwidth (similar to 100 nm), and large fabrication tolerance (+/- 10 nm) can be obtained by a 24.4 mu m coupling length DC structure, which is composed of a strip and a slot silicon waveguide. This design represents a first step toward mode splitter without changing the mode order, which can find important potential applications, such as optical isolation and mode division multiplexing (MDM), in large-scale photonic integrated circuits (PICs).</p

A comprehensive prognostic and immune analysis of enhancer RNA identifies IGFBP7-AS1 as a novel prognostic biomarker in Uterine Corpus Endometrial Carcinoma

Abstract Background Long non-coding RNAs (lncRNA) have been implicated in a hand of studies that supported an involvement and co-operation in Uterine Corpus Endometrial Carcinoma (UCEC). Enhancer RNAs (eRNA), a functional subtype of lncRNA, have a key role throughout the genome to guide protein production, thus potentially associated with diseases. Methods In this study, we mainly applied the Cancer Genome Atlas (TCGA) dataset to systematically discover crucial eRNAs involving UCEC. For the key eRNAs in UCEC, we employed RT-qPCR to compare eRNA expression levels in tumor tissues and paired normal adjacent tissues from UCEC patients for validation. Furthermore, the relationships between the key eRNAs and immune activities were measured from several aspects, including the analysis for tumor microenvironment, immune infiltration cells, immune check point genes, tumor mutation burden, and microsatellite instability, as well as m6A related genes. Finally, the key eRNAs were verified by a comprehensive pan-cancer analysis. Results IGFBP7 Antisense RNA 1 (IGFBP7-AS1) was identified as the key eRNA for its expression patterns of low levels in tumor tissues and favorable prognostic value in UCEC correlated with its target gene IGFBP7. In RT-qPCR analysis, IGFBP7-AS1 and IGFBP7 had down-regulated expression in tumor tissues, which was consistent with previous analysis. Moreover, IGFBP7-AS1 was found closely related with immune response in relevant immune analyses. Besides, IGFBP7-AS1 and its target gene IGFBP7 correlated with a multi-omics pan-cancer analysis. Conclusions Finally, we suggested that IGFBP7-AS1 played a key role in impacting on clinical outcomes of UCEC patients for its possible influence on immune activity

Frequency-degenerate parametric generation through IFWM effect in nanowaveguides

We investigate highly efficient frequency-degenerate parametric generation through inverse four-wave-mixing (IFWM) in silicon nanowaveguides, which exhibits distinctly from traditional FWM phenomenon and manifests itself as a unique process producing signal and idler photon pairs with frequencies at the center of two pumps. The influences of dispersion, nonlinear coefficient and frequency detuning on the IFWM process are numerically analyzed in detail. On this basis, the optimal condition for high gain IFWM and the nanowaveguide with high nonlinearity and large normal dispersion are proposed. These results substantiate the feasibility of such frequency-degenerate parametric generation in CMOS-compatible integrated platforms, which could find important potential in signal-processing systems for photonics networks and entangled qubits generation for quantum optics.</p