A GOOD ANGRY MAN : HARRY CAUDILL, THE FORMATIVE YEARS, 1922-1960

After the publication of Night Comes to the Cumberland: A Biography of a Depressed Area, Harry Caudill became a spokesperson for Appalachia. Throughout the 1960s, Caudill continued to challenge the corrupt political system of the Cumberland Valley. His indictment of the coal industry as a leading factor in the continual depression of the area led scholars and reformers to a better understanding of the interrelated dynamics affecting the region. Even though with the passage of time, scholars have rejected many of Caudills ideas concerning the mountain people, few doubt that he led the challenge against the political, economic, and social domination of the region during the 1960s. Because he played such an important role in reforming the region, a better understanding of the people and events that shaped his thinking demand attention. In an effort to better understand the man, this paper traveled through the formative years that shaped a mature Harry Caudill

Analyzing the Effects of Rejuvenators in Balanced Mix Design with High Percentages of Recycled Asphalt Pavement

Interest in sustainable practices have increased in several industries, including civil engineering pavement materials. The incorporation of Recycled Asphalt Pavement (RAP) into new pavement mix design is a popular method of application for sustainable practice and is accompanied by numerous economic and environmental benefits. There is significant interest in using large amounts of this RAP material in pavement design to maximize the benefits, but several problems arise when utilizing “high” amounts of this material (more than 25% RAP replacement) due to aged and oxidized binder that negatively impacts the properties. The use of rejuvenators (RAs) and Balanced Mix Design (BMD) are some solutions that are used to minimize negative impact on overall mix properties. RAs are added to high RAP-inclusive mixes to revitalize the RAP binder properties to allow for the best mix characteristics. BMD has quickly gained traction and popularity over the Superpave mix design method, as BMD considers the interaction effects of recycled materials and additives while also balancing performance testing results and designing pavement to a specific area condition. The application of sustainable practices such as high RAP mix design must result in a pavement that fulfills its purpose, and service life, and does not suffer from premature failure in the field for it to be worthwhile. Continuous research in this area of interest is crucial for the future of pavement materials. This research project aims to provide a methodical approach to high RAP mix design that can be applied to pavement design for future works. It also works to evaluate the performance of two RAs in RAP mixes at 25%, 50%, and 70% RAP replacement. The performance tests assess the rutting and cracking resistance with the goal of balancing these two so both perform adequately well. Additionally, two different RA doses are compared for RA1 (bio-based). A simple cost savings analysis is reviewed for the mix options per ton. Finally, a brief exploration of the chemical analysis comparison for different binder blends provides some insight into the different performance test results. The results of this research indicate a successful process of high RAP mix design and promising savings for the use of RAP in HMA mix design. The bio-based RA (RA1) performed the best overall of the two RAs, and the dose selection contrast of results reinforces that the initial method of RA dose selection is promising

Evaluating the Effectiveness of a Company\u27s Online Health and Safety Training Program by Assessing Its Employees Perceptions and Knowledge.

A cross-sectional study was conducted to evaluate a company’s online H & S training program. The ABC Company’s online 8-hr HAZWOPER refresher course is based on current OSHA standard topics required for certification and principles flexible to fit site- or task-specific situations and conditions. An 18-question survey was used to evaluate employee perceptions of online training compared to traditional classroom training. Perceptions were compared by demographic variables (e.g. gender, position, race, age and longevity with the ABC Company), which suggested that only age had an influence on employee response. Fifty-five percent of the employees surveyed preferred online training as compared to 45 percent for classroom training. The difference in percent was not significant (p \u3e0.05). Comparing pretest with posttest scores from the online training course identified an increase in retention of knowledge. Therefore, it was determined that the online training program is effective, at least from the company’s perspective

Increased incidence of kidney diseases in general practice after a nationwide albuminuria self-test program

<p>Abstract</p> <p>Background</p> <p>To study the influence of a nationwide albuminuria self-test program on the number of GP contacts for urinary complaints and/or kidney diseases and the number of newly diagnosed patients with kidney diseases by the GP.</p> <p>Methods</p> <p>Data were used from the Netherlands Information Network of General Practice (LINH), including a representative sample of general practices with a dynamic population of approximately 300.000 listed patients. Morbidity data were retrieved from electronic medical records, kept in a representative sample of general practices. The incidence of kidney diseases and urinary complaints before and after the albuminuria self-test program was compared with logistic regression analyses.</p> <p>Results</p> <p>Data were used from 139 general practices, including 444,220 registered patients. The number of GP consultations for kidney diseases and urinary complaints was increased in the year after the albuminuria self-test program and particularly shortly after the start of the program. Compared with the period before the self-test program, more patients have been diagnosed by the GP with symptoms/complaints of kidney disease and urinary diseases (OR = 1.7 (CI 1.4 - 2.0) and OR = 2.1 (CI 1.9 - 2.3), respectively). The odds on an abnormal urine-test in the period after the self-test program was three times higher than the year before (OR = 3.0 (CI 2.4 - 3.6)). The effect of the self-test program on newly diagnosed patients with an abnormal urine test was modified by both the presence of the risk factors hypertension and diabetes mellitus. For this diagnosis the highest OR was found in patients without both conditions (OR = 4.2 (CI 3.3 - 5.4)).</p> <p>Conclusions</p> <p>A nationwide albuminuria self-test program resulted in an increasing number of newly diagnosed kidney complaints and diseases the year after the program. The highest risks were found in patients without risk factors for kidney diseases.</p

The effect of linking community health centers to a state-level smoker's quitline on rates of cessation assistance

<p>Abstract</p> <p>Background</p> <p>Smoking cessation quitlines are an effective yet largely untapped resource for clinician referrals. The aim of this study was to assess the effect of a fax referral system that links community health centers (CHCs) with the New York State Quitline on rates of provider cessation assistance.</p> <p>Methods</p> <p>This study was conducted in four CHCs using a quasi experimental study design. Two comparison sites offered usual care (expanded vital sign chart stamp that prompted providers to ask about tobacco use, advice smokers to quit, assess readiness, and offer assistance (4As)) and two intervention sites received the chart stamp plus an office-based fax referral link to the New York State Quitline. The fax referral system links patients to a free proactive telephone counseling service. Provider adherence to the 4 As was assessed with 263 pre and 165 post cross sectional patient exit interviews at all four sites.</p> <p>Results</p> <p>Adherence to the 4As increased significantly over time in the intervention sites with no change from baseline in the comparison sites. Intervention sites were 2.4 (p < .008) times more likely to provide referrals to the state Quitline over time than the comparison sites and 1.8 (p < .001) times more likely to offer medication counseling and/or a prescription.</p> <p>Conclusions</p> <p>Referral links between CHCs and state level telephone quitlines may facilitate the provision of cessation assistance by offering clinicians a practical method for referring smokers to this effective service. Further studies are needed to confirm the efficacy of fax referral systems and to identify implementation strategies that work to facilitate the utilization of these systems across a wide range of clinical settings.</p

Rational selection of syngeneic preclinical tumor models for immunotherapeutic drug discovery

Murine syngeneic tumor models are critical to novel immuno-based therapy development, but the molecular and immunologic features of these models are still not clearly defined. The translational relevance of differences between the models is not fully understood, impeding appropriate preclinical model selection for target validation, and ultimately hindering drug development. Across a panel of commonly used murine syngeneic tumor models, we showed variable responsiveness to immunotherapies. We used array comparative genomic hybridization, whole-exome sequencing, exon microarray analysis, and flow cytometry to extensively characterize these models, which revealed striking differences that may underlie these contrasting response profiles. We identified strong differential gene expression in immune-related pathways and changes in immune cell-specific genes that suggested differences in tumor immune infiltrates between models. Further investigation using flow cytometry showed differences in both the composition and magnitude of the tumor immune infiltrates, identifying models that harbor "inflamed" and "noninflamed" tumor immune infiltrate phenotypes. We also found that immunosuppressive cell types predominated in syngeneic mouse tumor models that did not respond to immune-checkpoint blockade, whereas cytotoxic effector immune cells were enriched in responsive models. A cytotoxic cell-rich tumor immune infiltrate has been correlated with increased efficacy of immunotherapies in the clinic, and these differences could underlie the varying response profiles to immunotherapy between the syngeneic models. This characterization highlighted the importance of extensive profiling and will enable investigators to select appropriate models to interrogate the activity of immunotherapies as well as combinations with targeted therapies in vivo

Diagnosis and management in Rubinstein-Taybi syndrome:first international consensus statement

Rubinstein-Taybi syndrome (RTS) is an archetypical genetic syndrome that is characterised by intellectual disability, well-defined facial features, distal limb anomalies and atypical growth, among numerous other signs and symptoms. It is caused by variants in either of two genes (CREBBP, EP300) which encode for the proteins CBP and p300, which both have a function in transcription regulation and histone acetylation. As a group of international experts and national support groups dedicated to the syndrome, we realised that marked heterogeneity currently exists in clinical and molecular diagnostic approaches and care practices in various parts of the world. Here, we outline a series of recommendations that document the consensus of a group of international experts on clinical diagnostic criteria for types of RTS (RTS1: CREBBP; RTS2: EP300), molecular investigations, long-term management of various particular physical and behavioural issues and care planning. The recommendations as presented here will need to be evaluated for improvements to allow for continued optimisation of diagnostics and care.</p

Diagnosis and management in Rubinstein-Taybi syndrome:first international consensus statement

Rubinstein-Taybi syndrome (RTS) is an archetypical genetic syndrome that is characterised by intellectual disability, well-defined facial features, distal limb anomalies and atypical growth, among numerous other signs and symptoms. It is caused by variants in either of two genes (CREBBP, EP300) which encode for the proteins CBP and p300, which both have a function in transcription regulation and histone acetylation. As a group of international experts and national support groups dedicated to the syndrome, we realised that marked heterogeneity currently exists in clinical and molecular diagnostic approaches and care practices in various parts of the world. Here, we outline a series of recommendations that document the consensus of a group of international experts on clinical diagnostic criteria for types of RTS (RTS1: CREBBP; RTS2: EP300), molecular investigations, long-term management of various particular physical and behavioural issues and care planning. The recommendations as presented here will need to be evaluated for improvements to allow for continued optimisation of diagnostics and care.</p

Molecular psychiatry of zebrafish

Due to their well-characterized neural development and high genetic homology to mammals, zebrafish (Danio rerio) have emerged as a powerful model organism in the field of biological psychiatry. Here, we discuss the molecular psychiatry of zebrafish, and its implications for translational neuroscience research and modeling central nervous system (CNS) disorders. In particular, we outline recent genetic and technological developments allowing for in vivo examinations, high-throughput screening and whole-brain analyses in larval and adult zebrafish. We also summarize the application of these molecular techniques to the understanding of neuropsychiatric disease, outlining the potential of zebrafish for modeling complex brain disorders, including attention-deficit/hyperactivity disorder (ADHD), aggression, post-traumatic stress and substance abuse. Critically evaluating the advantages and limitations of larval and adult fish tests, we suggest that zebrafish models become a rapidly emerging new field in modern molecular psychiatry research

Anticipation in entrepreneurship

Entrepreneurship is a forward looking activity that embodies implicit imaginaries. If we remove the notion of a future from the field of entrepreneurship, field would cease to exist as its whole rationale is prospective. Entrepreneurship creates future value (Schumpeter 1934) through creative destruction; in uncertain contexts (Knight 1923) and with ‘alertness’ to opportunity (Kirzner 1982). Entrepreneurial opportunity em-braces anticipation as imaginative reason, strategically employed and motivated by aspiration. Entrepreneurial effectuation is concerned with the controllable aspects of an unpredictable future. Entrepreneuring is a process (Steyaert 2007) producing ontological emergence. Entrepreneurship is expressed in action and produces change. Nadin observes that anticipation relates to the perception of change (Nadin 2010) and is always expressed in action (Nadin 2015). Entrepreneurial identity is sig-nificant and the models embodied in an anticipatory system are what comprise its individuality; what distinguish it uniquely from other sys-tems. A change in these models is a change of identity (Rosen et al. 2012, p370). Entrepreneurship is relational and is coupled with other ac-tors in the environment, generating a sense of shared anticipation, or anticipatory coupling. Anticipatory coupling as a social phenomenon seems ripe for further research. Being emplaced, entrepreneuring practice involve sensing and anticipation (Antonacopoulou and Fuller 2019). Although anticipation is a natural activity, the effectiveness of anticipation can be improved through greater awareness in each of these sets of processes, among others. We suggest that the dynamics of emergence require anticipations of multiple forms of value. Seeing entrepreneurship from an anticipatory standpoint brings more to the fore the nature of values in practice. Further research can help reveal the anticipatory work is done in entrepreneurship to maintain the anticipatory capacity of the enterprise and of the interdependent relationships that maintain the enterprise