Mineralisation patterns in the subchondral bone plate of the humeral head

Purpose: Pathologic changes of the glenohumeral joint, like a long-standing overloading or an accident often lead to severe glenohumeral osteoarthritis, and a glenohumeral joint replacement could be necessary. Joint instability and glenoid loosening are the most common post-operative complications, which can be caused by eccentric loading of the glenoid, if the humeral head is malcentered. If these malcentered cases could be identified pre-operatively, the pathologic position of the humeral head could be fixed intra-operatively and complication may be prevented. Computed tomography osteoabsorptiometry (CT-OAM) is a useful method to determine the distribution of mineralisation in the subchondral bone as a marker for the long-term loading history of a joint. The objective of this study was to gain information about the mineralisation distribution in the subchondral bone plate of the humeral head. Methods: By the use of CT-OAM, the distribution of the subchondral mineralisation of 69 humeral heads was investigated and groups of mineralisation patterns were built. To evaluate if differences in age exist, the mean values of the two groups were compared using t test. Results: 49 humeral heads (71% of 69 specimens) showed bicentric subchondral mineralisation patterns with ventral and dorsal maxima, 20 humeral heads (29% of 69 specimens) could be classified as monocentric with a centro-dorsal maximum. We found no statistical significant difference between the age of the monocentric and the bicentric group on a significance level of 95%. Conclusion: We could show that stress distribution at the humeral head is typically bicentric with a ventral and dorsal maximum. However, other mineralisation patterns may occur under pathologic circumstances. The pre-operative identification of such cases by the use of CT-OAM could help to improve the post-operative results in shoulder surger

Osteoarthritis alters the patellar bones subchondral trabecular architecture

Following the principles of "morphology reveals biomechanics," the cartilage-osseous interface and the trabecular network show defined adaptation in response to physiological loading. In the case of a compromised relationship, the ability to support the load diminishes and the onset of osteoarthritis (OA) may arise. To describe and quantify the changes within the subchondral bone plate (SBP) and trabecular architecture, 10 human OA patellae were investigated by CT and micro-CT. The results are presented in comparison to a previously published dataset of 10 non-OA patellae which were evaluated in the same manner. The analyzed OA samples showed no distinctive mineralization pattern in regards to the physiological biomechanics, but a highly irregular disseminated distribution. In addition, no regularity in bone distribution and architecture across the trabecular network was found. We observed a decrease of material as the bone volume and trabecular thickness/number were significantly reduced. In comparison to non-OA samples, greatest differences for all parameters were found within the first mm of trabecular bone. The differences decreased toward the fifth mm in a logarithmic manner. The interpretation of the logarithmic relation leads to the conclusion that the main impact of OA on bony structures is located beneath the SBP and lessens with depth. In addition to the clear difference in material with approximately 12% less bone volume in the first mm in OA patellae, the architectural arrangement is more rod-like and isotropic, accounting for an architectural decrease in stability and support. (c) 2016 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res

Using the anatomical tibial axis for total knee arthroplasty alignment may lead to an internal rotation error

INTRODUCTION: Despite intensive research, current total knee arthroplasty (TKA) designs do not always provide the correct kinematics for the native joint and thus further optimisation is necessary. Several studies support the importance of malrotation of the tibial components in the failure of TKA. We hypothesise that using the anatomical tibial axis (ATA) to align tibial component rotation on the resected tibial surface may lead to an internal rotation error due to relative anterior shift of the lateral articular surface centre compared to the medial one. The aim of this study was to compare the anatomical tibial axis of the physiological tibial joint surface to the resected one. METHOD: Twenty formalin-fixed cadaveric knees were obtained for study. After computed tomography scanning the data of each specimen were entered into a standardised coordinate system and virtual bone cuts were performed with 6, 8 and 10 mm resection depths. The positions of the articular surface centres were determined at each resection depth. RESULTS: The lateral articular surface centre had moved anteriorly after the resection by a mean 1.475 mm, while the medial one had not changed significantly. Resecting the tibia at a 6-mm cut and using the transverse tibial axis to align the prosthetic tibial plateau will result in a mean 4.0 degrees (95 % confidence interval, 2.5-5.5 degrees ) of internal rotation compared to the uncut tibia. DISCUSSION: The ATA lies in 6 degrees of external rotation compared to the perpendicular to the posterior tibial condylar axis (PTCA). Graw et al. suggest aligning the tibial component in 10 degrees of external rotation to the latter. Thus, if we accept the above suggestion, the ATA is 4 degrees internally rotated compared to the same line on the resected proximal tibia. These prior studies appear to be in accordance with our findings. CONCLUSIONS: We conclude that using the ATA on the resected tibial surface may contribute to an internal rotation error

Mineralisation patterns in the subchondral bone plate of the humeral head

PURPOSE: Pathologic changes of the glenohumeral joint, like a long-standing overloading or an accident often lead to severe glenohumeral osteoarthritis, and a glenohumeral joint replacement could be necessary. Joint instability and glenoid loosening are the most common post-operative complications, which can be caused by eccentric loading of the glenoid, if the humeral head is malcentered. If these malcentered cases could be identified pre-operatively, the pathologic position of the humeral head could be fixed intra-operatively and complication may be prevented. Computed tomography osteoabsorptiometry (CT-OAM) is a useful method to determine the distribution of mineralisation in the subchondral bone as a marker for the long-term loading history of a joint. The objective of this study was to gain information about the mineralisation distribution in the subchondral bone plate of the humeral head. METHODS: By the use of CT-OAM, the distribution of the subchondral mineralisation of 69 humeral heads was investigated and groups of mineralisation patterns were built. To evaluate if differences in age exist, the mean values of the two groups were compared using t test. RESULTS: 49 humeral heads (71% of 69 specimens) showed bicentric subchondral mineralisation patterns with ventral and dorsal maxima, 20 humeral heads (29% of 69 specimens) could be classified as monocentric with a centro-dorsal maximum. We found no statistical significant difference between the age of the monocentric and the bicentric group on a significance level of 95%. CONCLUSION: We could show that stress distribution at the humeral head is typically bicentric with a ventral and dorsal maximum. However, other mineralisation patterns may occur under pathologic circumstances. The pre-operative identification of such cases by the use of CT-OAM could help to improve the post-operative results in shoulder surgery

Functional and Structural Details about the Fabella: What the Important Stabilizer Looks Like in the Central European Population

The posterolateral corner of the knee accommodating the fabella complex is of importance in orthopaedic surgery. Unfortunately, there is a lack of data in literature for clinical routine. Therefore, we investigated the fabella's characteristics, biomechanical nature, and present histologic details. Of special interest were the fabella's occurrence and position, calcium concentration as long-term load intake indicator, and the histology. Within our analysis, fabellae were found in 30.0% of all datasets, located on the upper part of the posterolateral femoral condyle. The region of fabella contact on this condyle showed a significantly lower calcium concentration than its surroundings. Histologically, the fabella showed no articular cartilage but a clearly distinguishable fabellofibular ligament that consisted of two bundles: one, as already described in literature inserted at the fibular tip, and another part newly described on the top of the lateral meniscus. In its role of stabilizing the soft tissue structures of the posterolateral knee, the fabella seems to serve as suspension for the ligaments evolving from its base. Even though a joint formation of any kind is unlikely, the presence of a fabella needs to be kept in mind during knee examination and any surgical procedures

The effect of knee flexion and rotation on the tibial tuberosity-trochlear groove distance

PURPOSE: The purpose was to measure the effect of flexion and additional rotation of the femur relative to the tibia on the tuberosity-trochlear groove distance (TT-TG) in the same subject in 20 cadaveric knees joint. METHODS: In 20 human adult cadavers, formal fixed knees (age: 81.9 years, SD 12.3; 10 female) CT scans were performed in extension and 30 degrees of flexion as well as in neutral, maximal possible internal (IR), and external rotation (ER). On superimposed CT scan images, TT-TG was measured in each position. TT-TG measurements were correlated in all knee positions. RESULTS: TT-TG in full extension/neutral rotation was 7.8 mm (SD 3.4, range, 2.4-15.3). TT-TG in full extension and IR was significantly lower, and TT-TG in full extension and ER was significantly higher than in neutral rotation (5.4 +/- 2.3 vs. 10.9 +/- 4.8 mm; P > 0.001). IR and ER varied between 1.0 degrees -7.6 degrees and 0.2 degrees -9.2 degrees , respectively. TT-TG in 30 degrees flexion/neutral rotation was 3.9 mm (SD 1.8, range, 1.3-7.8), which was significantly lower than in full extension and neutral rotation (P > 0.001). TT-TG in 30 degrees flexion and IR was significantly lower, and TT-TG in 30 degrees flexion and ER was significantly higher than values obtained in neutral rotation (2.7 +/- 1.2 vs. 6.5 +/- 3.4 mm; P > 0.001). IR and ER in 30 degrees flexion varied between 0.6 degrees -10.7 degrees and 1.9 degrees -13.0 degrees , respectively. CONCLUSION: Flexion as well as rotation of the knee joint significantly alters the TT-TG. These results may have wider clinical relevance in assessing TT-TG and further decisions based on it

Quantitative Evaluation of the Thickness of the Available Manipulation Volume Inside the Knee Joint Capsule for Minimally Invasive Robotic Unicondylar Knee Arthroplasty.

OBJECTIVE Developing robotic tools that introduce substantial changes in the surgical workflow is challenging because quantitative requirements are missing. Experiments on cadavers can provide valuable information to derive workspace requirements, tool size, and surgical workflow. This work aimed to quantify the volume inside the knee joint available for manipulation of minimally invasive robotic surgical tools. In particular, we aim to develop a novel procedure for minimally invasive unicompartmental knee arthroplasty (UKA) using a robotic laser-cutting tool. METHODS Contrast solution was injected into nine cadaveric knees and computed tomography scans were performed to evaluate the tool manipulation volume inside the knee joints. The volume and distribution of the contrast solution inside the knee joints were analyzed with respect to the femur, tibia, and the anatomical locations that need to be reached by a laser-cutting tool to perform bone resection for a standard UKA implant. RESULTS Quantitative information was determined about the tool manipulation volume inside these nine knee joints and its distribution around the cutting lines required for a standard implant. CONCLUSION Based on the volume distribution, we could suggest a possible workflow for minimally invasive UKA, which provides a large manipulation volume, and deducted that for the proposed workflow, an instrument with a thickness of 5-8 mm should be feasible. SIGNIFICANCE We present quantitative information on the three-dimensional distribution of the maximally available volume inside the knee joint. Such quantitative information lays the basis for developing surgical tools that introduce substantial changes in the surgical workflow

Mineralisation and mechanical strength of the glenoid cavity subchondral bone plate

PURPOSE: Failures in total shoulder replacements are often due to aseptic loosening of the glenoid component; the subchondral bone plate is an important factor governing primary fixation of implant materials. Therefore, we investigated characteristic mineralisation patterns of the subchondral bone plate, which demonstrate long-term stress on articular surfaces, age-related changes, postsurgical biomechanical situations and regions of fixation. Using computed tomography osteo-absorptiometry (CT-OAM), these distribution patterns can be demonstrated in vivo. The aim of this study was to investigate the relationship between subchondral bone-plate mineralisation measured with CT-OAM and the mechanical strength measured by indentation. METHODS: A total of 32 cadaverous glenoid cavities were evaluated by CT-OAM and indentation testing. Linear regression was used to compare mineralisation and strength of the subchondral bone plate. RESULTS: Results showed two patterns of mineralisation distribution. Twenty-eight cavities were related to bicentric distribution pattern and four showed a single maximum. The correlation coefficient between CT-OAM density and subchondral bone-plate strength was determined to be between 0.62 and 0.96 (P > 0.02). CONCLUSIONS: Long-term stress affects not only the subchondral but also the underlying cancellous bone. It therefore can be assumed that mineralisation patterns of the subchondral bone plate continue in cancellous bone. Areas of high density could serve as anchoring locations for orthopaedic implants in resurfacing the glenoid cavity