Autoantibodies against type I IFNs in patients with life-threatening COVID-19

Interindividual clinical variability in the course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is vast. We report that at least 101 of 987 patients with life-threatening coronavirus disease 2019 (COVID-19) pneumonia had neutralizing immunoglobulin G (IgG) autoantibodies (auto-Abs) against interferon-w (IFN-w) (13 patients), against the 13 types of IFN-a (36), or against both (52) at the onset of critical disease; a few also had auto-Abs against the other three type I IFNs. The auto-Abs neutralize the ability of the corresponding type I IFNs to block SARS-CoV-2 infection in vitro. These auto-Abs were not found in 663 individuals with asymptomatic or mild SARS-CoV-2 infection and were present in only 4 of 1227 healthy individuals. Patients with auto-Abs were aged 25 to 87 years and 95 of the 101 were men. A B cell autoimmune phenocopy of inborn errors of type I IFN immunity accounts for life-threatening COVID-19 pneumonia in at least 2.6% of women and 12.5% of men

Variabilidade espacial de propriedades de Latossolo e da produção de café em diferentes superfícies geomórficas Spatial variability of Latosol properties in different geomorphic surfaces of coffee cultivation

Com o objetivo de avaliar a variabilidade espacial de propriedades do solo e produção de café em diferentes Superfícies Geomórficas (SG) na região do Alto Paranaíba, MG, instalaram-se duas malhas de 200 x 850 m com intervalos regulares de 50 m, com 68 pontos amostrais cada uma, sob cultivo de café. As amostras de solo foram coletadas na profundidade de 0-0,20 m, nos pontos de intercessão dessas malhas. A produção de café foi avaliada em duas colheitas de grãos em coco das plantas mais próximas da intercessão de linhas das malhas. Calcularam-se as estatísticas descritivas e realizou-se a análise geoestatística de propriedades do solo e produção da cultura de café. As propriedades químicas e granulométricas de solos intensamente manejados, possuem dependência do relevo, mesmo de pequena expressão. A produção de café apresentou dependência espacial em ambas as superfícies e maior variabilidade na SG II. Os limites entre as superfícies geomórficas podem representar limites de locais específicos de manejo.<br>With the objective to evaluate the spatial variability of the soil properties and coffee production in different geomorphic surfaces (GS) in the region of the high Paranaíba, MG, two regular grids of 200 x 850 m with intervals of 50 m were installed with 68 sampling points under coffee crop. The soil samples were collected at 0-0.20 m depth at the intersection points of these grids. The coffee production was evaluated in plants closer to the intersection of the grid point. Descriptive statistics and geostatistics analysis of the soil properties and production of coffee crop were performed. The chemical and textural properties of soil intensely managed possess dependence of the relief, even for small expression. The coffee production presented spatial dependence in both surfaces and largest variability in GS II. The limits between the geomorphic surfaces can represent limits of specific places of management