66 research outputs found
A GENERALIZED CODE FOR COMPUTING CYCLIC REDUNDANCY CHECK
This paper focuses on developing a generalized CRC code where the user can vary the size of the generator polynomial [1] such as 9 bits (CRC-8), 17 bits (CRC-16), 33 bits (CRC-32), 65 bits (CRC-64). The working of the code has been shown taking an example and the resulting simulations obtained are shown
Statistics of Moduli Space of vector bundles II
Let be a smooth irreducible projective curve of genus over a
finite field \F_{q} of characteristic with elements such that the
function field \F_{q}(X) is a geometric Galois extension of the rational
function field of degree Consider , let be the
moduli space of rank stable vector bundles over with fixed determinant
isomorphic to a -rational line bundle . Suppose denotes the cardinality of the set of \F_{q}-rational points of
. We give an asymptotic bound of for large genus depending on . Further,
considering this logarithmic difference as a random variable, we prove a
central limit theorem over a large family of hyperelliptic curves with uniform
probability measure. Further, over the same family of hyperelliptic curves, we
study the distribution of \F_{q}-rational points over the moduli space of
rank stable vector bundles with trivial determinant
and it's Seshadri desingularisation
by choosing an appropriate random variable in each case. We
also see that the corresponding random variables having standard Gaussian
distribution as and tends to infinity.Comment: 28 page
Technology transfer in duopoly: the role of cost asymmetry
Abstract This article examines the possibility of a profitable technology transfer deal in a duopoly. We show that under a fixed fee contract, technology transfer will be always profitable if the products are sufficiently differentiated or the firms behave sufficiently cooperatively or both. Under a profit sharing contract, however, a profitable technology transfer deal always exists even in a market characterised by Cournot duopoly with homogeneous goods
Altered expression and editing of miRNA-100 regulates iTreg differentiation
RNA editing ofmiRNAs, especially in the seed region,
adds another layer to miRNA mediated gene regulation
which can modify its targets, altering cellular signaling
involved in important processes such as differentiation.
In this study, we have explored the role
of miRNA editing in CD4+ T cell differentiation. CD4+
T cells are an integral component of the adaptive immune
system. Na¨ıve CD4+ T cells, on encountering
an antigen, get differentiated either into inflammatory
subtypes like Th1, Th2 or Th17, or into immunosuppressive
subtype Treg, depending on the cytokine
milieu. We found C-to-U editing at fifth position of
mature miR-100, specifically in Treg. The C-to-U editing
of miR-100 is functionally associated with at least
one biologically relevant target change, from MTOR
to SMAD2. Treg cell polarization by TGFβ1 was reduced
by both edited and unedited miR-100 mimics,
but percentage of Treg in PBMCs was only reduced
by edited miR-100 mimics, suggesting a model in
which de-repression of MTOR due to loss of unedited
mir-100, promotes tolerogenic signaling, while gain
of edited miR-100 represses SMAD2, thereby limiting
the Treg. Such delicately counterbalanced systems
are a hallmark of immune plasticity and we propose
that miR-100 editing is a novel mechanism toward
this end
Recent Admixture in an Indian Population of African Ancestry
053907Quantum Matter and Optic
Genome-wide analysis identifies common CNVs associated with primary open angle glaucoma
BackgroundCopy number variation (CNV) is one of the major factors contributing to genomic diversity and diseases. Glaucoma is a major neurodegenerative disease causing irreversible vision loss across the globe. We wanted to analyze the impact of common CNVs in a genome-wide scale in patients of primary open angle glaucoma (POAG) collected from the West Bengal, India.MethodGenome-wide data was generated on 364 POAG cases and 365 controls on Illumina 660W-Quad arrays and CNVs were called using PennCNV. Copy number variant regions (CNVRs) were analyzed for association. A publicly available dataset of POAG cohort of 866 cases and 495 controls from Caucasian origin (GLAUGEN study) was used as a validation cohort. Representative CNVs were validated using real-time PCR.ResultsWe analyzed genome-wide CNV from 1928 samples. After association analysis we found 308 significantly associated (p<0.05) CNVRs in the Indian data. These POAG associated CNVRs were enriched in nervous system development. 113 CNVRs (37%) were significantly associated with the Caucasian data set. These contain 5 genes previously reported in eye diseases, namely, IDUA, FOXE3, NDUF7, PRPF6 and WNT3. We also found 6 associated CNVRs in previously known glaucoma loci.ConclusionWe have shown that common CNVRs are significantly associated in both datasets irrespective of the population background. We have also identified candidate genes/regions which are uniquely present in POAG cases and absent in controls. Our data might provide new insights into role of CNV in pathogenesis of POAG
De novo copy number variations in candidate genomic regions in patients of severe autism spectrum disorder in Vietnam
Autism spectrum disorder (ASD) is a developmental disorder with a prevalence of around 1% children worldwide and characterized by patient behaviour (communication, social interaction, and personal development). Data on the efficacy of diagnostic tests using copy number variations (CNVs) in candidate genes in ASD is currently around 10% but it is overrepresented by patients of Caucasian background. We report here that the diagnostic success of de novo candidate CNVs in Vietnamese ASD patients is around 6%. We recruited one hundred trios (both parents and a child) where the child was clinically diagnosed with ASD while the parents were not affected. We performed genetic screening to exclude RETT syndrome and Fragile X syndrome and performed genome-wide DNA microarray (aCGH) on all probands and their parents to analyse for de novo CNVs. We detected 1708 non-redundant CNVs in 100 patients and 118 (7%) of them were de novo. Using the filter for known CNVs from the Simons Foundation Autism Research Initiative (SFARI) database, we identified six CNVs (one gain and five loss CNVs) in six patients (3 males and 3 females). Notably, 3 of our patients had a deletion involving the SHANK3 gene–which is the highest compared to previous reports. This is the first report of candidate CNVs in ASD patients from Vietnam and provides the framework for building a CNV based test as the first tier screening for clinical management
CDK19 is disrupted in a female patient with bilateral congenital retinal folds, microcephaly and mild mental retardation
Microcephaly, mental retardation and congenital retinal folds along with other systemic features have previously been reported as a separate clinical entity. The sporadic nature of the syndrome and lack of clear inheritance patterns pointed to a genetic heterogeneity. Here, we report a genetic analysis of a female patient with microcephaly, congenital bilateral falciform retinal folds, nystagmus, and mental retardation. Karyotyping revealed a de novo pericentric inversion in chromosome 6 with breakpoints in 6p12.1 and 6q21. Fluorescence in situ hybridization analysis narrowed down the region around the breakpoints, and the breakpoint at 6q21 was found to disrupt the CDK19 gene. CDK19 was found to be expressed in a diverse range of tissues including fetal eye and fetal brain. Quantitative PCR of the CDK19 transcript from Epstein–Barr virus-transformed lymphoblastoid cell lines of the patient revealed ~50% reduction in the transcript (p = 0.02), suggesting haploinsufficiency of the gene. cdk8, the closest orthologue of human CDK19 in Drosophila has been shown to play a major role in eye development. Conditional knock-down of Drosophila cdk8 in multiple dendrite (md) neurons resulted in 35% reduced dendritic branching and altered morphology of the dendritic arbour, which appeared to be due in part to a loss of small higher order branches. In addition, Cdk8 mutant md neurons showed diminished dendritic fields revealing an important role of the CDK19 orthologue in the developing nervous system of Drosophila. This is the first time the CDK19 gene, a component of the mediator co-activator complex, has been linked to a human disease
GENOMIC 'UNITY IN DIVERSITY' OF INDIA AND ITS IMPLICATIONS FOR GENOMIC MEDICINE
The Indian Genome Variation Consortium is one of the most ambitious endeavors taken up by th
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