31 research outputs found
Pathology of Eupatorium adenophorum (Sticky snakeroot) toxicity in mice
The leaves of Eupatorium adenophorum Spreng were powdered and extracted with methanol. An acute oral toxicity study was conducted in male Swiss albino mice and a LD50 of 3501 mg/kg was obtained during 14 days observation period. Twenty Swiss albino mice (male) randomly divided into four groups were administered orally with vehicle (5% tween 80), 1/20th (i.e. 175 mg/kg), 1/10th (i.e. 350 mg/kg) and 1/5th (i.e. 750 mg/kg) LD50 doses of methanolic leaf extract of E. adenophorum Spreng; respectively for a period of 30 days. The mice were sacrificed on day-31 and the liver dissected out freed from adherent tissue weighed to nearest milligram. The liver histology, estimations of biochemical contents and enzyme activities were carried out. Treatment of the mice with methanolic extract of E. adenophorum at the dose level of 750 mg/kg (i.e. 1/5th LD50) elicited hepatotoxicity and the animals had yellow discoloration of liver, subcutaneous tissue and musculature indicating jaundice. Study on liver enzymes revealed marked increase in the activities of alkaline phosphatase (ALP), alanine transaminase (ALT), aspartate transaminase (AST) and lactate dehydrogenase (LDH), while significant increase in serum bilirubin level. Histopathological examination of the livers of the group IV animals had focal areas of necrosis and bile duct proliferation. Elevation in plasma bilirubin concomitant with alterations in enzyme profile and histopathological lesions are consistent with liver injury and cholestasi
Particle density fluctuations
Event-by-event fluctuations in the multiplicities of charged particles and
photons at SPS energies are discussed. Fluctuations are studied by controlling
the centrality of the reaction and rapidity acceptance of the detectors.
Results are also presented on the event-by-event study of correlations between
the multiplicity of charged particles and photons to search for DCC-like
signals.Comment: Talk presented at Quark Matter 2002, Nantes, Franc
RANTES levels in peripheral blood, CSF and contused brain tissue as a marker for outcome in traumatic brain injury (TBI) patients
Preparation of carbon nanotubes on the surface of magadiite impregnated with cobalt (II) and Iron ions.
Preparation of carbon nanotubes on the surface of magadiite impregnated with cobalt (II) and Iron ions.
Hypofibrinogenemia in isolated traumatic brain injury in Indian patients
Coagulation abnormalities are common in patients with head injuries.
However, the effect of brain injury on fibrinogen levels has not been
well studied prospectively to assess coagulation abnormalities in
patients with moderate and severe head injuries and correlate these
abnormalities with the neurologic outcome. Consecutive patients with
moderate (Glasgow Comma Scale (GCS),9-12) and severe (GCS≤8) head
injuries were the subjects of this pilot study, All patients had
coagulation parameters, including plasma fibrinogen levels measured.
Clinical and computed tomography (CT) scan findings and immediate
clinical outcome were analyzed. Of the 100 patients enrolled, only
seven (7%) patients had hypofibrinogenemia (fibrinogen ≤200
mg/dL). The head injury was moderate in two patients and severe in five
patients. Fibrinogen levels showed a progressively increasing trend in
four patients (three with severe head injuries and one with moderate
head injury). CT scan revealed subdural hematoma in five patients;
extradural hematoma in one; and subarachnoid hemorrhage in another
patient. Of the seven patients, two patients died during hospital.
Large-scale prospective studies are needed to assess the fibrinogen
level in patients with head injury and its impact on outcome