Usunięcie przemieszczonych stentów z pnia lewej tętnicy wieńcowej w trakcie przezskórnej interwencji wieńcowej techniką trappingu

Dislodgement and embolisation of the new generation of drug eluting stents is a very rare but recognized and potentially serious complication of percutaneous coronary intervention (PCI). Various methods from including tangling wire, bioptome, and goose neck snare to surgical removal have been described. Here we report a case of successful retrieval of a deformed coronary stent from left main coronary artery by trapping technique.Przemieszczenie stentu nowej generacji wydzielającego lek i związany z tym zator to bardzo rzadkie, lecz znane powikłanie przezskórnej interwencji wieńcowej, które może się wiązać z poważnymi następstwami. Opisywano różne metody chirurgicznego usunięcia stentu z życiem rozmaitych narzędzi endoskopowych, w tym narzędzi z końcówką w postaci splątanego drutu, szczypczyków biopsyjnych i pętli. W niniejszej pracy przedstawiono przypadek skutecznej ewakuacji zdeformowanego stentu wieńcowego z pnia lewej tętnicy wieńcowej techniką trappingu

The Botany, Chemistry, Pharmacological and Therapeutic Application of Oxalis Corniculata Linn– A Review

Oxalis corniculata Linn. is an endangered and medicinally important plant indigenous to tropical and subtropical regions of the world. Its medicinal usage is reported in Indian pharmaceutical codex, the Chinese, British and the American pharmacopoeias and in different traditional system of medicines such as Ayurveda, Unani and Siddha. The review reveals that wide ranges of phytochemical constituents have been isolated from the plant like flavanoids, tannins, phytosterols, phenol, glycoseides, fatty acids, galacto-glycerolipid and volatile oil. The leaves contain flavonoids, iso vitexine and vitexine-2”- O- beta – D- glucopyrunoside. It is rich source of essential fatty acids like palmitic acid, oleic, linoleic, linolenic and stearic acids and it possesses important activities like Antioxidant, Anticancer, anthelmintic, Anti-inflammatory, Analgesic, Steroidogenic, Antimicrobial, Antiamoebic, Antifungal, Astringent, Depurative, Diuretic, Emmenagogue, Febrifuge, Cardio relaxan, stomachic and Styptic have also been reported. These repots are very encouraging and indicate that herb should be studied more expensively for its therapeutic benefits. This article briefly reviews the botany, pharmacology, biochemistry and therapeutic application of the plant. This is an attempt to compile and document information on different aspects of Oxalis corniculata and highlight the need for research and development. Keywords: Oxalis corniculata, Galacto-glycerolipid, Pharmacological activities, Antioxidant, Anticancer

The Botany, Chemistry, Pharmacological and Therapeutic Application of Oxalis Corniculata Linn– A Review

Oxalis corniculata Linn. is an endangered and medicinally important plant indigenous to tropical and subtropical regions of the world. Its medicinal usage is reported in Indian pharmaceutical codex, the Chinese, British and the American pharmacopoeias and in different traditional system of medicines such as Ayurveda, Unani and Siddha. The review reveals that wide ranges of phytochemical constituents have been isolated from the plant like flavanoids, tannins, phytosterols, phenol, glycoseides, fatty acids, galacto-glycerolipid and volatile oil. The leaves contain flavonoids, iso vitexine and vitexine-2”- O- beta – D- glucopyrunoside. It is rich source of essential fatty acids like palmitic acid, oleic, linoleic, linolenic and stearic acids and it possesses important activities like Antioxidant, Anticancer, anthelmintic, Anti-inflammatory, Analgesic, Steroidogenic, Antimicrobial, Antiamoebic, Antifungal, Astringent, Depurative, Diuretic, Emmenagogue, Febrifuge, Cardio relaxan, stomachic and Styptic have also been reported. These repots are very encouraging and indicate that herb should be studied more expensively for its therapeutic benefits. This article briefly reviews the botany, pharmacology, biochemistry and therapeutic application of the plant. This is an attempt to compile and document information on different aspects of Oxalis corniculata and highlight the need for research and development. Keywords: Oxalis corniculata, Galacto-glycerolipid, Pharmacological activities, Antioxidant, Anticancer

Izolowana ciężka stenoza trójpłatkowej zastawki aortalnej u 8-letniego chłopca

A 8-year-old boy was referred for evaluation of ejection systolic murmur. On examination multiple xanthomas and xanthelesmas were noted. Investigations confirmed familial hypercholesterolemia and severe aortic stenosis in background of tricuspid aortic valve. We report a case of severe aortic stenosis in background of morphologically normal valve, a rare complication of heterozygous familial hypercholesterolaemia.Ośmioletni chłopiec został skierowany do ośrodka w celu oceny skurczowego szmeru typu wyrzutowego. W badaniu przedmiotowym stwierdzono liczne kępki żółte i kępki żółte płaskie. Na podstawie przeprowadzonych badań rozpoznano hipercholesterolemię rodzinną (FH) i ciężką stenozę zastawki aortalnej o budowie trójpłatkowej. Autorzy opisują przypadek ciężkiej stenozy aortalnej u pacjenta z prawidłową morfologicznie zastawką aortalną, co jest rzadkim powikłaniem heterozygotycznej postaci FH

Percutaneous retrieval of a fractured multipurpose catheter by an indigenous snare in a 25-year-old patient: a safe and feasible approach

Since the first report of percutaneous retrieval of intravascular foreign body in 1964, it has become a favourite approach for intravascular foreign body removal. Snares, biopsy forceps, dormia basket or tip deflecting wires are available options for this approach. Herein, we report percutaneous retrieval a fractured multipurpose catheter by an indigenous snare in a 25-year-old patient. The patient was a 25-year-old male being admitted with ostium secundum atrial septal defect and catheterization study was planned for shunt quantification. During manipulation to right ventricular outflow tract, multipurpose catheter got broken approx. 4 cm. proximal to tip. The broken part was captured through right femoral vein by a self-constructed snare. While removal, it broke at tip of venous sheath. Smaller one was retrieved and bigger was recaptured and finally retrieved by exaggerating the curve of same snare without any complications. Use of snares for intravascular foreign body removal is frequently reported and has been successful with low complication rates.Since the first report of percutaneous retrieval of intravascular foreign body in 1964, it has become a favourite approach for intravascular foreign body removal. Snares, biopsy forceps, dormia basket or tip deflecting wires are available options for this approach. Herein, we report percutaneous retrieval a fractured multipurpose catheter by an indigenous snare in a 25-year-old patient. The patient was a 25-year-old male being admitted with ostium secundum atrial septal defect and catheterization study was planned for shunt quantification. During manipulation to right ventricular outflow tract, multipurpose catheter got broken approx. 4 cm. proximal to tip. The broken part was captured through right femoral vein by a self-constructed snare. While removal, it broke at tip of venous sheath. Smaller one was retrieved and bigger was recaptured and finally retrieved by exaggerating the curve of same snare without any complications. Use of snares for intravascular foreign body removal is frequently reported and has been successful with low complication rates

Skuteczne usunięcie przemieszczonego prowadnika z końcówką w kształcie „J” za pomocą samodzielnie skonstruowanej pętli u 75-letniego pacjenta — bezpieczna i dostępna metoda

Since the first report of percutaneous retrieval of intravascular foreign body in 1964, it has been accepted as a favourite approach for intravascular foreign body removal. Snares, biopsy forceps, dormia basket or tip deflecting wires are available in the armamentarium for this approach. Herein, we report percutaneous retrieval of a dislodged J-tip guide-wire by self-constructed snare. A patient was a 75-year-old woman who was admitted with capture failure following post pacemaker implantation. J-tip guide-wire was inadvertently left in her inferior vena cava during temporary pacemaker insertion. The guide wire was approached through right subclavian vein by a self-constructed snare and it was removed without any complications. Use of snares for intravascular foreign body removal is frequently reported and has been successful with low complication rates; also, the low cost of such snares makes it safe and economical.Od publikacji pierwszego doniesienia o przezskórnym usunięciu śródnaczyniowego ciała obcego w 1964 roku metoda ta jest najczęściej wybieraną techniką w przypadku śródnaczyniowej lokalizacji ciała obcego. Dostępne instrumentarium do takich zabiegów obejmują pętle, kleszczyki biopsyjne, koszyki typu dormia oraz prowadniki z giętką końcówką. W niniejszej pracy opisano przezskórne usunięcie przemieszczonego prowadnika z końcówką w kształcie „J” za pomocą pętli własnej konstrukcji. Kobieta w wieku 75 lat została przyjęta do placówki medycznej po nieudanej próbie usunięcia ciała obcego pozostałego po wszczepieniu stymulatora serca. Podczas wprowadzania czasowego stymulatora przypadkowo pozostawiono prowadnik z końcówką w kształcie „J” w żyle głównej dolnej pacjentki. Prowadnik uchwycono za pomocą pętli własnej konstrukcji wprowadzonej przez prawą tętnicę podobojczykową, a następnie wydobyto bez powikłań. Dostępnych jest wiele publikacji opisujących wykorzystanie pętli do usuwania śródnaczyniowych ciał obcych jako metody skutecznej i cechującej się niskim odsetkiem powikłań. Niskie koszty tego rodzaju pętli sprawiają, że metoda ta jest nie tylko bezpieczna, ale i ekonomiczna

Joga i rehabilitacja kardiologiczna (Yoga-CaRe) u osób po przebyciu ostrego epizodu wieńcowego

Cardiovascular diseases are a leading cause of death and disability in Asian Indians with huge psychological and economic impact as it affects population in thirty- and forty-year-olds, previously healthy adults and most productive social group. Successful transcatheter therapeutics has opened a new vista for its management; however, it cannot prevent its recurrence. Therefore, secondary prevention is cornerstone of management. Yoga-based Cardiac Rehabilitation (Yoga-CaRe) is a multifaceted approach targeting patient’s physical, psychological, social and occupational status, preventing or delaying the progression of underlying disease and reducing the risk of recurrent rehospitalization and death as well as enabling the patients to live a comfortable and active life. Yoga is an ancient Indian system of philosophy; a mind-body discipline encompassing an array of philosophical precepts, mental attitudes and physical practice. Of seven major branches of yoga, Hatha yoga, which itself includes many different styles (e.g. Iyenger, Ashtanga, etc.), is probably the most commonly recognized, and incorporates elements of physical poses, breath control and meditation, and self-restraint (including that of diet, smoking, alcohol intake and sleep patterns). A Cochrane review reported a 27% reduction in total mortality and 19% reduction in total mortality and non-fatal cardiac events with cardiac rehabilitation (CR), comparing favorably to effective pharmacological treatments (e.g. antiplatelets, angiotensin-converting enzyme inhibitors, statins and beta-blockers). Yoga, therefore, could provide a useful frame work on which to develop an economical CR program, with additional advantages of being culturally appropriate to Indians and potentially be appealing to global population.Choroby układu sercowo-naczyniowego są główną przyczyną zgonów i niepełnosprawności mieszkańców Indii, a ponadto mają ogromny wpływ psychologiczny i ekonomiczny, ponieważ często dotykają 30- i 40-latków, wcześniej niechorujących, którzy stanowią najbardziej produktywną grupę społeczną. Skuteczne techniki przezcewnikowe otworzyły nowe perspektywy w leczeniu tych chorób, jednak nie mogą zapobiec ich nawrotom. Z tego względu podstawowe znaczenie ma prewencja wtórna. Rehabilitacja kardiologiczna oparta na jodze (Yoga-CaRe) to wielopłaszczyznowe podejście oddziałujące na sferę fizyczną, psychiczną, społeczną i zawodową, którego celem jest zapobieganie lub spowalnianie progresji choroby podstawowej i obniżenie ryzyka ponownej hospitalizacji lub zgonu, a także poprawa komfortu życia i zachowanie pełnej aktywności. Joga to starożytny hinduski system filozoficzny, którego istotą jest dyscyplina ciała i umysłu i który obejmuje szereg reguł filozoficznych oraz ćwiczeń mentalnych i fizycznych. Spośród siedmiu głównych odmian jogi najbardziej znaną jest Hatha yoga, która również obejmuje wiele różnych rodzajów (tj. Iyenger, Ashtanga etc.) i łączy element ćwiczeń fizycznych, kontroli oddechu i medytacji z samoograniczeniami (dotyczącymi diety, palenia tytoniu, spożywania alkoholu i snu). W przeglądzie danych dostępnych w bazie Cochrane wykazano, że rehabilitacja kardiologiczna (CR) powoduje zmniejszenie o 27% śmiertelności całkowitej oraz o 19% śmiertelności całkowitej i zdarzeń sercowych niezakończonych zgonem, a więc pozwala uzyskać korzystniejsze efekty niż skuteczna farmakoterapia (tj. leki przeciwpłytkowe, inhibitory konwertazy angiotensyny, statyny i antagoniści receptorów beta-adrenergicznych). Joga może być użyteczna jako podstawa do opracowania ekonomicznego program CR, a jej dodatkowym atutem jest zgodność z kulturą Indii i popularność na całym świecie

Ancient mtDNA from the extinct Indian cheetah supports unexpectedly deep divergence from African cheetahs

Abstract: The Indian cheetah was hunted to extinction by the mid-20th century. While analysis of 139 bp of mitochondrial DNA (mtDNA) has confirmed that the Indian cheetah was part of the Asiatic subspecies (Acinonyx jubatus venaticus), the detailed relationships between cheetah populations remains unclear due to limited genetic data. We clarify these relationships by studying larger fragments of cheetah mtDNA, both from an Indian cheetah museum specimen and two African cheetah, one modern and one historic, imported into India at different times. Our results suggest that the most recent common ancestor of cheetah mtDNA is approximately twice as ancient as currently recognised. The Indian and Southeast African (Acinonyx jubatus jubatus) cheetah mtDNA diverged approximately 72 kya, while the Southeast and Northeast African (Acinonyx jubatus soemmeringii) cheetah mtDNA diverged around 139 kya. Additionally, the historic African cheetah sampled from India proved to have an A. j. jubatus haplotype, suggesting a hitherto unrecognised South African route of cheetah importation into India in the 19th century. Together, our results provide a deeper understanding of the relationships between cheetah subspecies, and have important implications for the conservation of A. j. venaticus and potential reintroduction of cheetahs into India

Ancient mtDNA from the extinct Indian cheetah supports unexpectedly deep divergence from African cheetahs

Abstract: The Indian cheetah was hunted to extinction by the mid-20th century. While analysis of 139 bp of mitochondrial DNA (mtDNA) has confirmed that the Indian cheetah was part of the Asiatic subspecies (Acinonyx jubatus venaticus), the detailed relationships between cheetah populations remains unclear due to limited genetic data. We clarify these relationships by studying larger fragments of cheetah mtDNA, both from an Indian cheetah museum specimen and two African cheetah, one modern and one historic, imported into India at different times. Our results suggest that the most recent common ancestor of cheetah mtDNA is approximately twice as ancient as currently recognised. The Indian and Southeast African (Acinonyx jubatus jubatus) cheetah mtDNA diverged approximately 72 kya, while the Southeast and Northeast African (Acinonyx jubatus soemmeringii) cheetah mtDNA diverged around 139 kya. Additionally, the historic African cheetah sampled from India proved to have an A. j. jubatus haplotype, suggesting a hitherto unrecognised South African route of cheetah importation into India in the 19th century. Together, our results provide a deeper understanding of the relationships between cheetah subspecies, and have important implications for the conservation of A. j. venaticus and potential reintroduction of cheetahs into India

Ethnomedicinal Plants Used in the Health Care System: Survey of the Mid Hills of Solan District, Himachal Pradesh, India

The study was performed in the mid hills of the Dharampur region in Solan district of Himachal Pradesh, India. At the study site, a total of 115 medicinal plants were documented (38 trees, 37 herbs, 34 shrubs, 5 climbers, 1 fern, and 1 grass). In the study region, extensive field surveys were performed between March 2020 and August 2021. Indigenous knowledge of wild medicinal plants was collected through questionnaires, discussions, and personal interviews during field trips. Plants with their correct nomenclature were arranged by botanical name, family, common name, habitat, parts used, routes used, and diseases treated. In the present study, the predominant family was Rosaceae, which represented the maximum number of plant species, 10, followed by Asteraceae and Lamiaceae, which represented 8 plant species. The rural inhabitants of the Dharampur region in the Solan district have been using local plants for primary health care and the treatment of various diseases for a longer time. However, information related to the traditional knowledge of medicinal plants was not documented. The rural inhabitants of the Dharampur region reported that the new generation is not so interested in traditional knowledge of medicinal plants due to modernization in society, so there is an urgent need to document ethnomedicinal plants before such knowledge becomes inaccessible and extinct