Significance of occult neoplastic cells on tumor metastasis: a case report of gastric cancer

<p>Abstract</p> <p>Background</p> <p>Occult neoplastic cells (ONCs) are the tumor cells floating in the lymph node sinuses, distant from the primary tumor, and supposed to be one of most reliable marker of prognosis.</p> <p>Methods</p> <p>We report here the case of a 52-year-old woman with a gastric cancer associated by numerous ONCs.</p> <p>Results</p> <p>Postoperative examination of the stomach disclosed an advanced, poorly differentiated adenocarcinoma with frequent lymph node metastases. In addition to ONCs and occasional micrometastases, focal aggregates of ONCs, one of the possible intermediate lesions between the ONCs and the usual metastases, are also observed.</p> <p>Conclusions</p> <p>In the present case, at least some of ONCs seem to form the microaggregates of tumor cells in lymph nodes, anchor in the sinuses, and grow up to the large tumorous lesion. Even if most of the ONCs were trapped and disappeared under the influence of tumor immunity, the detection of ONCs could be one of the reliable clues to estimate the prognosis.</p

X-ray observations of VY Scl type nova-like binaries in the high and low state

Four VY Scl-type nova-like systems were observed in X-rays during both the low and the high optical states. We examined Chandra, ROSAT, Swift and Suzaku archival observations of BZ Cam, MV Lyr, TT Ari, and V794 Aql. The X-ray flux of BZ Cam is higher during the low state, but there is no supersoft X-ray source (SSS) as hypothesized in previous articles. No SSS was detected in the low state of the any of the other systems, with the X-ray flux decreasing by a factor between 2 and 50. The best fit to the Swift X-ray spectra is obtained with a multi-component model of plasma in collisional ionization equilibrium. The high state high resolution spectra of TT Ari taken with Chandra ACIS-S and the HETG gratings show a rich emission line spectrum, with prominent lines of in Mg, Si, Ne, and S. The complexity of this spectrum seems to have origin in more than one region, or more than one single physical mechanism. While several emission lines are consistent with a cooling flow in an accretion stream, there is at least an additional component. We discuss the origin of this component, which is probably arising in a wind from the system. We also examine the possibility that the VY Scl systems may be intermediate polars, and that while the boundary layer of the accretion disk emits only in the extreme ultraviolet, part of the X-ray flux may be due to magnetically driven accretion.Comment: 13 pages, 8 figures, 7 tables. Accepted for publication by MNRA

IGR J14257-6117, a magnetic accreting white dwarf with a very strong X-ray orbital modulation

IGR J14257-6117 is an unclassified source in the hard X-ray catalogues. Optical follow-ups suggest it could be a Cataclysmic Variable of the magnetic type. We present the first high S/N X-ray observation performed by \XMM\ at 0.3--10 keV, complemented with 10--80 keV coverage by \Swift/BAT, aimed at revealing the source nature. We detected for the first time a fast periodic variability at 509.5\,s and a longer periodic variability at 4.05\,h, ascribed to the white dwarf (WD) spin and binary orbital periods, respectively. These unambiguously identify IGR J14257-6117 as a magnetic CV of the Intermediate Polar (IP) type. The energy resolved light curves at both periods reveal amplitudes decreasing with increasing energy, with the orbital modulation reaching $\sim100\%$ in the softest band. The energy spectrum shows optically thin thermal emission with an excess at the iron complex, absorbed by two dense media (${\rm N_{H}\sim10^{22-23}\,cm^{-2}}$), partially covering the X-ray source. These are likely localised in the magnetically confined accretion flow above the WD surface and at the disc rim, producing the energy dependent spin and orbital variabilities, respectively. IGR J14257-6117, joins the group of strongest orbitally modulated IPs now counting four systems. Drawing similarities with low-mass X-ray binaries displaying orbital dips, these IPs should be seen at large orbital inclinations allowing azimuthally extended absorbing material fixed in the binary frame to intercept the line of sight. For IGR J14257-6117, we estimate ($50^o\,\lesssim\,i\,\lesssim\,70^o$). Whether also the mass accretion rate plays a role in the large orbital modulations in IPs cannot be established with the present data.Comment: Accepted for publication on MNRAS. 9 pages, 6 table, 5 figure

EUVE Observations of the Magnetic Cataclysmic Variable QQ Vulpeculae

We present simultaneous X-ray (lambda_peak ~ 44A) and EUV (lambda_peak = 89A) light curves for the magnetic cataclysmic variable QQ Vulpeculae, obtained with the EUVE satellite. We find that the unique shape of the X-ray light curve is different from previously obtained X-ray light curves of QQ Vul and provides evidence for two-pole accretion. Detailed examination of the photometric data indicates that QQ Vul undergoes a stellar eclipse of the X-ray emitting region, indicative of a high binary inclination. We discuss possible implications for the nature of this system given the observed shape of its EUV and X-ray light curves.Comment: 12 pages including 4 figures, accepted to PAS

Constraining the Accretion Geometry of the Intermediate Polar EX Hya Using NuSTAR, Swift, and Chandra Observations

In magnetically accreting white dwarfs, the height above the white dwarf surface where the standing shock is formed is intimately related with the accretion rate and the white dwarf mass. However, it is difficult to measure. We obtained new data with NuSTAR and Swift that, together with archival Chandra data, allow us to constrain the height of the shock in the intermediate polar EX Hya. We conclude that the shock has to form at least at a distance of about one white dwarf radius from the surface in order to explain the weak Fe Kα 6.4 keV line, the absence of a reflection hump in the high-energy continuum, and the energy dependence of the white dwarf spin pulsed fraction. Additionally, the NuSTAR data allowed us to measure the true, uncontaminated hard X-ray (12-40 keV) flux, whose measurement was contaminated by the nearby galaxy cluster Abell 3528 in non-imaging X-ray instruments.Fil: Luna, Gerardo Juan Manuel. Consejo Nacional de Investigaciónes Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Astronomía y Física del Espacio. - Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Astronomía y Física del Espacio; ArgentinaFil: Mukai, K.. National Aeronautics and Space Administration; Estados UnidosFil: Orio, M.. Università di Padova; ItaliaFil: Zemko, P.. Università di Padova; Itali

Large-scale analysis of human alternative protein isoforms: pattern classification and correlation with subcellular localization signals

We investigated human alternative protein isoforms of >2600 genes based on full-length cDNA clones and SwissProt. We classified the isoforms and examined their co-occurrence for each gene. Further, we investigated potential relationships between these changes and differential subcellular localization. The two most abundant patterns were the one with different C-terminal regions and the one with an internal insertion, which together account for 43% of the total. Although changes of the N-terminal region are less common than those of the C-terminal region, extension of the C-terminal region is much less common than that of the N-terminal region, probably because of the difficulty of removing stop codons in one isoform. We also found that there are some frequently used combinations of co-occurrence in alternative isoforms. We interpret this as evidence that there is some structural relationship which produces a repertoire of isoformal patterns. Finally, many terminal changes are predicted to cause differential subcellular localization, especially in targeting either peroxisomes or mitochondria. Our study sheds new light on the enrichment of the human proteome through alternative splicing and related events. Our database of alternative protein isoforms is available through the internet

Symbiotic stars in X-rays II: faint sources detected with XMM-Newton and Chandra

We report the detection, with ${\it Chandra}$ and XMM-${\it Newton}$, of faint, soft X-ray emission from four symbiotics stars that were not known to be X-ray sources. These four object show a $\beta$-type X-ray spectrum, i.e. their spectra can be modeled with an absorbed optically thin thermal emission with temperatures of a few million degrees. Photometric series obtained with the Optical Monitor on board XMM-${\it Newton}$ from V2416 Sgr and NSV 25735 support the proposed scenario where the X-ray emission is produced in a shock-heated region inside the symbiotic nebulae.Comment: 5 pages, 1 figure, 2 tables; A&A publishe