Complementarity of Semileptonic BB to K2∗(1430)K_2^*(1430) and K∗(892)K^*(892) Decays in the Standard Model with Fourth Generation

The $B\rightarrow K_{2}^{\ast}(1430)l^{+}l^{-}$ $(l=\mu,\tau)$ decays are analyzed in the Standard Model extended to fourth generation of quarks (SM4). The decay rate, forward-backward asymmetry, lepton polarization asymmetries and the helicity fractions of the final state $K^{*}_{2}(1430)$ meson are obtained using the form factors calculated in the light cone sum rules (LCSR) approach. We have utilized the constraints on different fourth generation parameters obtained from the experimental information on $K$, $B$ and $D$ decays and from the electroweak precision data to explore their impact on the $B\rightarrow K_{2}^{\ast}(1430)l^{+}l^{-}$ decay. We find that the values of above mentioned physical observables deviate deviate significantly from their minimal SM predications. We also identify a number of correlations between various observables in $B\rightarrow K_{2}^{\ast}(1430)l^{+}l^{-}$ and $B\rightarrow K^{\ast}(892)l^{+}l^{-}$ decays. Therefore a combined analysis of these two decays will compliment each other in the searches of SM4 effects in flavor physics.Comment: 28 pages, 12 figure

Statefinder Parameter for Varying G in Three Fluid System

In this work, we have considered variable G in flat FRW universe filled with the mixture of dark energy, dark matter and radiation. If there is no interaction between the three fluids, the deceleration parameter and statefinder parameters have been calculated in terms of dimensionless density parameters which can be fixed by observational data. Also the interaction between three fluids has been analyzed due to constant $G$. The statefinder parameters also calculated in two cases: pressure is constant and pressure is variable.Comment: 5 pages, Accepted for publication in "Astrophysics and Space Science

Reconstruction of some cosmological models in f(R,T) gravity

In this paper, we reconstruct cosmological models in the framework of $f(R,T)$ gravity, where $R$ is the Ricci scalar and $T$ is the trace of the stress-energy tensor. We show that the dust fluid reproduces $\Lambda$CDM, phantom-non-phantom era and the phantom cosmology. Further, we reconstruct different cosmological models including, Chaplygin gas, scalar field with some specific forms of $f(R,T)$. Our numerical simulation for Hubble parameter shows good agreement with the BAO observational data for low redshifts $z<2$.Comment: 12 pages, 2 figure

Analisis Usaha Kecil Menengah Rumah Makan Padang

Currently, competition in the world of work is getting tougher and unemployment is increasing. Forcing the government to immediately overcome unemployment by expanding job opportunities is impossible. Unemployment does not only come from people who do not have expertise in certain fields but also from employees who are retired early by companies, both large and small companies. Thus, you can imagine how many Indonesians do not have jobs. In this case there must be awareness from the whole community to play an active role in overcoming unemployment because the government only helps with government programs such as UKM (Small and Medium Enterprises). When running a small and medium business, you need a business analysis so that the business can run well, one of these businesses is a Padang restaurant. The aim of the research is to analyze small and medium Padang restaurant businesses. This research uses qualitative methods and is classified as field research with semi-structured interviews and documentation as data collection techniques. The findings from this research are that there are several things that need to be improved in managing a Padang restaurant business, including: the quality of the food must remain stable, the taste of the employees is friendly, the business premises are clean, prayer places must be provided and so on

Examining the effects of HIV self-testing compared to standard HIV testing services in the general population: A systematic review and meta-analysis

BACKGROUND: We updated a 2017 systematic review and compared the effects of HIV self-testing (HIVST) to standard HIV testing services to understand effective service delivery models among the general population. METHODS: We included randomized controlled trials (RCTs) comparing testing outcomes with HIVST to standard testing in the general population and published between January 1, 2006 and June 4, 2019. Random effects meta-analysis was conducted and pooled risk ratios (RRs) were reported. The certainty of evidence was determined using the GRADE methodology. FINDINGS: We identified 14 eligible RCTs, 13 of which were conducted in sub-Saharan Africa. Support provided to self-testers ranged from no/basic support to one-on-one in-person support. HIVST increased testing uptake overall (RR:2.09; 95% confidence interval: 1.69-2.58; INTERPRETATION: HIVST appears to be safe and effective among the general population in sub-Saharan Africa with a range of delivery models. It identified and linked additional people with HIV to care. These findings support the wider availability of HIVST to reach those who may not otherwise access testing

Globrauneine A–F: six new triterpenoid esters from the leaves of Globimetula braunii

Phytochemical study was conducted on the leaves of Globimetula braunii which is a hemi parasitic plant belonging to the family Loranthaceae. Extraction was carried out using cold extraction method with increasing polarity of solvents i.e n-hexane, CH2Cl2 and MeOH. The components were separated by chromatographic technique and the structures of the compounds were elucidated by extensive spectroscopic analyses including MS, FTIR, 1D and 2D NMR, HRMS and chemical methods. Six new pentacyclic triterpenoid esters named as globrauneine A (1), globrauneine B (2), globrauneine C (3), globrauneine D (4), globrauneine E (5), and globrauneine F (6), together with six known compounds (7 – 12) were successfully isolated from the leaves of G. braunii growing on Piliostigma thonningii. These results depict a substantial support to the chemotaxonomy of the genus Globimetula

Importance and Significance of UF/MF Membrane Systems in Desalination Water Treatment

The proposed chapter addresses a comprehensive overview of the history and future outlook of ultrafiltration/microfiltration (UF/MF) membrane for desalination water pretreatment. Known theories on UF/MF membrane formation from phase inversion (Dr/wet) systems can be prolonged to define the consequences of high or low molecular weight additives. Also, direct material reengineering and surface modification for high-performance anti-fouling of UF/MF membranes are also highlighted. Before the modern final polymeric film, the characterization techniques, particularly molecular weight cut-off, pore size, pore size distribution, and microbiological activity classification, on to the UF/MF membrane surface were presented, respectively. Lab scale to commercial scale UF/MF membrane configuration and market size of UF/MF membranes for pretreatment desalination are described. The significance of UF/MF provided here as an unconventional approach for desalination water pretreatment is in contrast with the current conventionally used technologies. The recent development made in the integration of established desalination processes, such as spiral wound reverse osmosis (SWRO), multi-stage flash (MSF), multi-effect distillation (MED), electrodialysis (ED) desalination, and UF pretreatment, is addressed. Finally, the influence of UF/MF on desalination water pretreatment step on to the energy cost of desalination process system is discussed

Country uptake of WHO recommendations on differentiated HIV testing services approaches: a global policy review

OBJECTIVES: In 2015 and 2016, WHO issued guidelines on HIV testing services (HTS) highlighting recommendations for a strategic mix of differentiated HTS approaches. The policy review examines the uptake of differentiated HTS approaches recommendations in national policies. METHODS: Data were extracted from national policies published between January 2015 and June 2019. The WHO-recommended HTS approaches included facility-based testing, community-based testing, HIV self-testing and provider-assisted referral (or assisted partner notification). Other supportive recommendations include pre-test information, post-test counselling, lay provider testing and rapid testing. Descriptive analyses were conducted to examine inclusion of recommendations in national policies. RESULTS: Of 194 countries worldwide, 65 published policies were identified; 24 WHO Africa region (AFR) countries (51%, 24/47), 21 WHO European region (EUR) (40%, 21/53), 6 WHO Eastern Mediterranean region (EMR) (29%, 6/21), 5 Pan-American region (AMR) (14%, 5/35), 5 Western Pacific Region (WPR) (19%, 5/27) and 4 WHO South East Asia Region (SEAR) (36%, 4/11). Only five countries included all recommendations. 63 included a minimum of one. 85% (n=55) included facility-based testing for pregnant women, 75% (n=49) facility-based testing for key populations, 74% (n=48) community-based testing for key populations, 69% (n=45) rapid testing, 57% (n=37) post-test counselling, 45% (n=29) lay provider testing, 38% (n=25) HIV self-testing, 29% (n=19) pre-test information and 25% (n=16) provider-assisted referral. The proportion in each region that included at least one recommendation were: 100% AFR (24/47), 100% EMR (6/6), 100% AMR (5/5), 100% WPR (5/5), 100% SEAR (4/4) and 95% EUR (20/21). AFR followed by EMR included the highest number of reccomendations. CONCLUSION: There was substantial variability in the uptake of the WHO-differentiated HTS recommendations. Those in EMR included the most WHO-differentiated HTS recommendation followed by AFR. Countries within AMR included the least number of recommendations. Ongoing advocacy and efforts are needed to support the uptake of the WHO-differentiated HTS recommendations in country policies as well as their implementation

ESAT6-Induced IFNγ and CXCL9 Can Differentiate Severity of Tuberculosis

BACKGROUND: Protective responses against Mycobacterium tuberculosis are dependent on appropriate T cell and macrophage activation. Mycobacterial antigen six kDa early secreted antigenic target (ESAT6) and culture filtrate protein 10 (CFP10) can detect M. tuberculosis specific IFNgamma responses. However, most studies have been performed in non-endemic regions and to study pulmonary tuberculosis (PTB). We have studied ESAT6 and CFP10 induced cytokine and chemokines responses in PTB and extrapulmonary (EPul) TB. METHODOLOGY: IFNgamma, IL10, CXCL9 and CCL2 responses were determined using an ex vivo whole blood assay system in PTB (n = 30) and EPulTB patients with limited (LNTB, n = 24) or severe (SevTB, n = 22) disease, and in healthy endemic controls (ECs). Responses to bacterial LPS were also determined. PRINCIPAL FINDINGS: ESAT6- and CFP10-induced IFNgamma was comparable between ECs and TB patients. Both ESAT6- and CFP10-induced IFNgamma secretion was greater in LNTB than PTB. ESAT6-induced CXCL9 was greater in EPulTB as compared with PTB, with an increase in SevTB as compared with LNTB. CFP10-induced CCL2 was higher in PTB than LNTB patients. LPS-stimulated CXCL9 was greatest in SevTB and LPS-induced CCL2 was increased in PTB as compared with LNTB patients. A positive correlation between ESAT6-induced IFNgamma and CXCL9 was present in all TB patients, but IFNgamma and CCL2 was only correlated in LNTB. ESAT-induced CCL2 and CXCL9 were significantly associated in LNTB while correlation in response to LPS was only present in SevTB. CONCLUSIONS: ESAT6 induced IFNgamma and CXCL9 can differentiate between limited and severe TB infections

Country adherence to WHO recommendations to improve the quality of HIV diagnosis: a global policy review.

INTRODUCTION: Ensuring a correct and timely HIV diagnosis is critical. WHO publishes guidelines on HIV testing strategies that maximise the likelihood of correctly determining one's HIV status. A review of national HIV testing policies in 2014 found low adherence to WHO guidelines. We updated this review to determine adherence to current recommendations. METHODS: We conducted a comprehensive policy review through April 2018. We extracted data on HIV testing strategies, recommendations on HIV retesting prior to antiretroviral therapy (ART) initiation and pre-exposure prophylaxis (PrEP)-related HIV testing information. Descriptive analyses disaggregated by region were conducted to ascertain adherence to recommendations and to describe testing strategy characteristics. RESULTS: Of 91 policies included, 26% (n=24/91) adhered to WHO recommendations. Having a two-assay testing strategy to rule-in HIV infection as opposed to the recommended three-assay testing strategy was a major reason for non-adherence. Of 72 country policies providing sufficient information, 31% (n=22) recommended retesting for HIV prior to initiating ART. Of 25 countries and two regions reporting PrEP-related HIV testing guidelines, almost all recommended testing prior to initiating PrEP and every 3 months during PrEP use. CONCLUSIONS: Global adherence to WHO recommendations for HIV testing strategies have improved since 2014 but remain low. We found adherence existed on a continuum. Such a system provides insights into how countries can move towards adherence by making relatively minor changes to testing strategies. Guidance from WHO on the role of new HIV testing technologies within testing algorithms and identifying ways to simplify testing guidance is warranted