Prevalence of Sleep Paralysis in the Medical Students of a Local Medical College

Abstract Objective: To find out the prevalence of sleep paralysis among the medical students of a local Pakistani medical college. Methodology: This cross-sectional study was conducted on 107 medical students from, Karachi Institute of Medical Sciences (KIMS), Karachi, Pakistan. Non-probability Convenient Sampling Technique was utilized for this study. Students suffering from any psychiatric illness were excluded from this study. The study was performed after taking permission from the Institutional Ethical Review Committee. Written informed consent was taken from all the students. The data were collected using a pretested predesigned Questionnaire which was consisted of 10 questions related to the common10 happening and symptoms of sleep paralysis. Data were recorded in the form of frequency and percentages and analyzed using SPSS 24. Results: 52% (56 out of 107) participants have had an experience of sleep paralysis. Most of the participants (76.6%) described their experience as an Inability to move. Frequency of experience ranged from 0 to 20 times in the last year. Age at first experience ranged between 10-20 years. Conclusion: We found a high prevalence of sleep paralysis (47.2%) among the medical students at a local Pakistani medical college. Majority of the students experienced the phenomenon multiple times in their life. The students associated the symptoms the factors such as academic stress, anxiety, workload, emotional experiences, sleep deprivation, work routine, sleep pattern, sleep deprivation, fatigue, mental disturbance, studies and routine stress. 37.3% of the students also related the phenomenon to their position of sleep (lying on back). The participants described the experience as a source of great distress. Sleep paralysis needs to be studied, investigated and addressed in context of mental health of the students

SIGNIFICANCE OF ANTIOXIDANTS IN MAINTAINING DAIRY AND BEEF ANIMALS’ HEALTH

Oxidation and reduction reactions occurring inside the cell must be maintained in the state of equilibrium so that the integrity of cells can be maintained and production of the animals remains at optimum. If there is imbalance between redox reaction, health of the animals gets affected in terms of onset of various reproductive disorders and diseases like mastitis. A number of antioxidants are produced naturally inside the body but under stressful endogenous and exogenous environment, their production is hampered. Thus, supplementation of animals with antioxidants like vitamin C and Vitamin E in feed or parenteral administration is essential to keep the animal healthy to get maximum possible production

FLUID DYNAMICS IN COAL BED METHANE RESERVOIR AND ITS MODELLING WHILE INCLUDING THE EFFECT OF FRACTURE PERMEABILITY AND MATRIX-FRACTURE FLOW COEFFICIENT

Coal gas is generated through biogenic and thermogenic processes during coalification. The two porosity systems exist in coal; micropores contains gas in adsorbed form, whereas, macropores (cleats) act as a transport media. Diffusion of gas molecules within matrix & matrix-matrix interaction is governed by Fick’s law of diffusion. In this work in-depth analysis has been made regarding gas flow dynamics and governing processes controlling such mechanisms. Further, compositional modelling has been conducted to investigate the effect of matrix to fracture flow parameter on overall flow dynamics and recovery. The numerical modeling of the flow behavior in coal seams is more complicated than conventional reservoir, as they differ in terms of storage and flow mechanisms. In such modellings, reservoir is divided into matrix and fracture system, where gas is absorbed in matrix and fractures acts as transport medium. The obtained results show that fracture permeability and matrix-fracture flow parameter strongly effects the overall field production and hence recovery

Biodiesel Production from Waste Plant Oil over a Novel Nano-Catalyst of Li-TiO2/Feldspar

A novel Li-impregnated TiO2 catalyst loaded on feldspar mineral (Li-TiO2/feldspar) was synthesized via a wet impregnation method and was characterized using X-ray diffraction (XRD), scanning electron microscopy (SEM), and Fourier transform infrared (FTIR) analysis. Using these techniques, it was possible to confirm the catalyst’s structural organization with a high crystallinity. This catalyst was used in the transesterification of five waste plant oils of Citrullus colocynthis (bitter apple), Pongamia pinnata (karanja), Sinapis arvensis (wild mustard), Ricinus communis (castor) and Carthamus oxyacantha (wild safflower). The catalytic tests were performed at temperatures ranging from 40 to 80 °C, employing a variable methanol/ester molar ratio (5:1, 10:1, 15:1, 20:1 and 25:1) and different catalyst concentrations (0.5%, 1%, 1.5%, 2% and 2.5%) relative to the total reactants mass. Conversion of 98.4% of fatty acid methyl esters (FAMEs) was achieved for Pongamia pinnata (karanja). The main fatty acids present in bitter apple, karanja, wild mustard, castor and wild safflower oils were linoleic acid (70.71%), oleic acid (51.92%), erucic acid (41.43%), ricinoleic acid (80.54%) and linoleic acid (75.17%), respectively. Li-TiO2/feldspar produced more than 96% for all the feedstocks. Fuel properties such as iodine value (AV), cetane number (CN), cloud point (CP), iodine value (IV), pour point (PP) and density were within the ranges specified in ASTM D6751

Biodiesel Production from Waste Plant Oil over a Novel Nano-Catalyst of Li-TiO₂/Feldspar

A novel Li-impregnated TiO2 catalyst loaded on feldspar mineral (Li-TiO2/feldspar) was synthesized via a wet impregnation method and was characterized using X-ray diffraction (XRD), scanning electron microscopy (SEM), and Fourier transform infrared (FTIR) analysis. Using these techniques, it was possible to confirm the catalyst’s structural organization with a high crystallinity. This catalyst was used in the transesterification of five waste plant oils of Citrullus colocynthis (bitter apple), Pongamia pinnata (karanja), Sinapis arvensis (wild mustard), Ricinus communis (castor) and Carthamus oxyacantha (wild safflower). The catalytic tests were performed at temperatures ranging from 40 to 80 °C, employing a variable methanol/ester molar ratio (5:1, 10:1, 15:1, 20:1 and 25:1) and different catalyst concentrations (0.5%, 1%, 1.5%, 2% and 2.5%) relative to the total reactants mass. Conversion of 98.4% of fatty acid methyl esters (FAMEs) was achieved for Pongamia pinnata (karanja). The main fatty acids present in bitter apple, karanja, wild mustard, castor and wild safflower oils were linoleic acid (70.71%), oleic acid (51.92%), erucic acid (41.43%), ricinoleic acid (80.54%) and linoleic acid (75.17%), respectively. Li-TiO2/feldspar produced more than 96% for all the feedstocks. Fuel properties such as iodine value (AV), cetane number (CN), cloud point (CP), iodine value (IV), pour point (PP) and density were within the ranges specified in ASTM D6751

Performance enhancement of water and energy efficient foam dyeing and finishing through different foaming agents

Foam dyeing and finishing is an ecofriendly alternative to conventional padding in textile processing. However, the generation and application of foam is a challenging task especially for wide range of dyes and chemicals due to technical and compatibility issues. In the foam dyeing and finishing process, foaming agent plays a central role. However, there is a lack of research on the compatibility of range of foaming agents with the range of different dyes and finishes. Therefore, in this research, foam was generated and optimized for seven different colorants including three reactive dyes, two direct dyes, and two pigments, and three different finishes including softener, oil and water repellent, and fire retardant using three different foaming agents separately. These foaming agents are alkyl dimethyl amine oxide, alkane sulfonate sodium salt, and ethoxylated decanol. Foam was successfully generated, optimized, and applied on the cotton fabric. Performance of the fabric samples treated with padding and three foaming agents for each dye and finish was evaluated. In most of the foam dyeing and foam finishing recipes, alkane sulfonate sodium salt-based foaming agent indicated the best dyeing and finishing properties and its performance was comparable with conventional padding in addition to significant savings of water, chemicals, and energy

In Silico Characterization and Analysis of Clinically Significant Variants of Lipase-H (LIPH Gene) Protein Associated with Hypotrichosis

Hypotrichosis is an uncommon type of alopecia (hair loss) characterized by coarse scalp hair caused by the reduced or fully terminated activity of the Lipase-H (LIPH) enzyme. LIPH gene mutations contribute to the development of irregular or non-functional proteins. Because several cellular processes, including cell maturation and proliferation, are inhibited when this enzyme is inactive, the hair follicles become structurally unreliable, undeveloped, and immature. This results in brittle hair, as well as altered hair shaft development and structure. Because of these nsSNPs, the protein’s structure and/or function may be altered. Given the difficulty in discovering functional SNPs in genes associated with disease, it is possible to assess potential functional SNPs before conducting broader population investigations. As a result, in our in silico analysis, we separated potentially hazardous nsSNPs of the LIPH gene from benign representatives using a variety of sequencing and architecture-based bioinformatics approaches. Using seven prediction algorithms, 9 out of a total of 215 nsSNPs were shown to be the most likely to cause harm. In order to distinguish between potentially harmful and benign nsSNPs of the LIPH gene, in our in silico investigation, we employed a range of sequence- and architecture-based bioinformatics techniques. Three nsSNPs (W108R, C246S, and H248N) were chosen as potentially harmful. The present findings will likely be helpful in future large population-based studies, as well as in drug discovery, particularly in the creation of personalized medicine, since this study provides an initial thorough investigation of the functional nsSNPs of LIPH