Pharmacokinetics of Caffeic Acid from Methanol Seed Extract of Syzygium cumini L in Rats

Purpose: To describe caffeic acid-based pharmacokinetics of methanol extract of seed of Syzygium cumini L. in rats.Methods: A dose of the extract (500 mg, equivalent to 37.135 mg caffeic acid) was administered orally to 6 male Wister rats, weighing 200 ± 10 g. Blood samples (0.5 mL), collected from the tail vein at 0, 15, 30, 60, 120, 240 and 720 min, were processed and analyzed using high performance liquid chromatography and detected with florescent light detector (FLD).Results: Following the administration of the extract, caffeic acid achieved maximum plasma concentration (5.96 ± 0.49 μg/mL) in 1.0 h which was also the time to achieve maximum concentration (Tmax). Mean resident time (MRT) and half-life (t1/2) were 4.092 ± 0.94 h and 0.14 ± 0.01 h, respectively.Conclusion: The results indicate that absorption of caffeic acid from the oral route is fast, but lower amounts are absorbed. The method developed for the extraction of caffeic acid from the plasma and HPLC determination may be useful in establishing phyto-bioequivalence between Syzygium cumini seed products.Keywords: Caffeic acid, Pharmacokinetics, Syzygium cumini, Phytobioequivalence, Absorptio

COMPARATIVE EFFICACY OF HYPERTONIC SALINE AND NORMAL SALINE SOLUTIONS IN EXPERIMENTALLY INDUCED ENDOTOXIC SHOCK IN DOGS

This study was contemplated to determine the comparative beneficial effects of hypertonic saline solution and sterile saline solution in induced endotoxic shock in dogs. For this purpose, 12 healthy Mongrel dogs were randomly divided into two equal groups (A and B). All the animals were induced endotoxaemia by slow intravenous administration of Escherichia coli endotoxins 0111:B4. Group A was treated with normal saline solution @ 90 ml/kg BW, while group B was given hypertonic saline solution @ 4 ml/kg BW, followed by normal saline solution @ 10 ml/kg BW. Different parameters were observed for evaluation of these fluids including clinical and haematological parameters, serum electrolytes, mean arterial pressure, and blood gases at different time intervals up to 24 hours post treatments. After infusion of respective fluids, all parameters returned to baseline values in both the groups but group B showed better results than group A except bicarbonates, which better recovered in group A. Thus, it was concluded that a small-volume of hypertonic saline solution could be effectively used in reversing the endotoxaemia. Moreover, it provides a rapid and inexpensive resuscitation from endotoxic shock

Energy Content of Colliding Plane Waves using Approximate Noether Symmetries

This paper is devoted to study the energy content of colliding plane waves using approximate Noether symmetries. For this purpose, we use approximate Lie symmetry method of Lagrangian for differential equations. We formulate the first-order perturbed Lagrangian for colliding plane electromagnetic and gravitational waves. It is shown that in both cases, there does not existComment: 18 pages, accepted for publication in Brazilian J Physic

Evaluation of seeds of phoenix sylvestris as novel candidate adsorbent in paracetamol poisoning

The adsorption of certain metal ions and dyes on powdered seeds (pits) of Phoenix sylvestris (Arecaceae) suggests the investigation of such material for the adsorption of oral poisoning substances from the gastrointestinal tract. Therefore, the present study was undertaken to prepare different types of adsorbents from date pits and explore their adsorption capacity for paracetamol at two physiological conditions, enzyme free simulated gastric and intestinal fluids. The activated charcoal was used as a control. The equilibrium contact time, determined by combining the three forms of date pits and activated charcoal separately with paracetamol in a ratio of 15:1 w/w in both the fluids, was found to be 60 min. The adsorption of all the adsorbents for paracetamol was investigated by increasing the amount of adsorbents while keeping the amount of adsorbate fix, and the data obtained was found to be fit in the Langmuir isotherm. The bonding constants of all the adsorbents were significantly different in SGF (p < 0.05), whereas not significantly different in SIF. The adsorption capacities of all the adsorbents were not significantly different in SGF, whereas, significantly different in SIF (p < 0.05). The results of this study indicate that date pits may be used to prepare activated carbon that may serve as an economical adsorbent for the management of paracetamol oral poisoning cases.Colegio de Farmacéuticos de la Provincia de Buenos Aire

Experimental investigation of long-term performance of fiber-reinforced epoxy and polyurethane polymer composites

The primary challenge encountered by polymers and their composites when exposed to saline water is their inadequate ability to withstand wear and tear over time. With a potential to replace conventional materials the long-term performance of FRP composites is still a novice area. This manuscript thus, reports an experimental investigation and prediction of the durability of fiber-reinforced polymer composites exposed to seawater at different temperatures. E-glass/epoxy and E-glass/polyurethane samples were exposed to 23 °C, 45 °C and 65 °C seawater for up to 2700 days (90 months). Tensile tests evaluated the mechanical performance of the composite as a function of exposure time, and strength-based technique was used to assess the durability. The experimental results revealed that the tensile strength of E-glass/epoxy composite decreased by 6.3% and 48.9% after 90 months in seawater at 23 and 65 °C, respectively, whereas it declined by 37.6% and 63.6% respectively for E-glass/Polyurethane composite. The prolonged immersion in seawater results in plasticization and swelling in the composite material, which accelerates the fiber/matrix debonding. SEM micrographs indicate fiber/matrix debonding, potholing, fiber pull-out, river line marks, and matrix cracking which showcases deterioration in the tensile properties of both composites

Project managers' personality and project success : moderating role of external environmental factors

Successful project completion is a challenging phenomenon for project managers. Various factors play an indispensable role in the success of a project. The objective of this study is to examine the role of project managers’ personalities in project success with the moderating role of external environmental factors i.e., political, economic, social. The study includes 145 project managers from 36 large‐scale construction projects, from both the public and private sectors. The big five personality model was used to evaluate the personality traits of project managers and triple constraint criteria (cost, time, and quality) was used to gauge project success. Data has been collected through a well‐structured questionnaire. The analysis of data indicated that personality traits like extraversion and openness are positive predictors of project success, whereas conscientiousness, agreeableness, and neuroticism did not have any direct relationship with project success. Importantly, the findings of this study concluded that external environmental factors—like political, economic, and social— moderately influence the link of specific project managers’ personality traits to project success. The role of external environmental factors as moderators has been discussed. The findings indicate the essential personality traits, as well as the role of external factors for achieving project success. The research contributions have relevance to both theory and practice and provide a deeper insight that is useful for individuals, organizations, researchers, practitioners, and decision‐makers

EXPERIMENTAL TRIALS OF LIVE ATTENUATED AND INACTIVATED STAPHYLOCOCCUS AUREUS VACCINES IN RABBITS

This study was conducted as a preliminary step on the rabbits for comparative efficacy of different vaccines of Staphylococcus aureus. Typical alpha-beta Staph. aureus species from a clinically affected mastitic buffalo was isolated. After proper identification based on cultural and morphological characteristics and API-Staph Trac system, a selected Staph. aureus isolate was used to prepare four different mastitis vaccines (Bacterin, oil-adjuvanted, dextran sulphate adjuvanted and live attenuated) after confirmation for pathogenicity and antigenicity, followed by its safety and sterility evaluation. Vaccines were tried in 25 rabbits divided into 5 equal groups. A separate vaccine was administered s/c @ 0.2 ml per animal and boosted at 15 days later. It was found that IHA antibody titers were higher (GMT 32-128) in live attenuated, dextran sulphate adjuvanted (GMT 32-128) and oil-adjuvanted (GMT 16-64) than the bacterin treated (GMT 16-32) group. All the vaccines showed an apparent immune response than the unvaccinated control group

COVID-19 challenges : can industry 4.0 technologies help with business continuity?

The COVID-19 pandemic has halted economic activities and made business dynamics much more challenging by introducing several additional operational, structural, and managerial constraints. The problem has affected global supply chains in many ways, and has questioned their long-term continuity. On the other hand, Industry 4.0 is an emerging phenomenon. However, there is a need to investigate how Industry 4.0 technologies may play a potential role in sustaining business operations to ease unprecedented causalities. The current research aims to investigate the potentiality of Industry 4.0 technologies to solve the COVID-19 challenges for long term sustainability. From an exploratory literature analysis coupled with the Delphi method, keeping in view the situation of the pandemic, ten challenge groups that have affected global business dynamics were identified. A questionnaire was developed with the aim of accumulating industrial and academic experts to evaluate the degree of influence and interrelationship among the identified challenges. The Decision Making, Trial and Evaluation Laboratory (DEMATEL) approach was deployed to further analyze the challenges for the categorization of these into causes and effects, further prioritizing them for better decision making. The prioritized challenges from the list of causes were governmental policies and support, followed by real access to customers and a lack of infrastructure. Additionally, these challenges were further evaluated through the expert opinion of Industry 4.0 systems experts and strategic-level supply chain experts to potentially gauge the potency of Industry 4.0 technologies to solve COVID-19-induced challenges. The outcomes of this research (which used Delphi integrated with a DEMATEL approach) are expected to support businesses in formulating strategies with the aim of business continuity in combating future disruptions caused by COVID-19-like pandemics

Adsorption of paracetamol on activated charcoal in the presence of dextropropoxyphene hydrochloride, N-acetylcysteine and sorbitol

Paracetamol, an over the counter analgesic and antipyretic drug, causes hepatic and renal tubular necrosis at higher doses ingested accidentally, or intentionally. The situation worsens clinically upon the ingestion of product containing paracetamol and dextropropoxyphene. In paracetamol poisoning, activated charcoal is used to adsorb the drug from the gastrointestinal tract, sorbitol to remove charcoaldrug complexes and N-acetylcysteine to reduce the drug and its metabolites from systemic circulation. Activated charcoal being non-specific adsorbent may adsorb other chemical moieties from the intestine as well as antidotes. Therefore, the present study aimed to investigate the adsorption of paracetamol on activated charcoal in presence of dextropropoxyphene hydrochloride, N-acetylcysteine and sorbitol. Paracetamol was combined separately with dextropropoxyphene hydrochloride, N-acetylcysteine and sorbitol. These mixtures were combined with varying amounts of activated charcoal to evaluate the in vitro adsorption of paracetamol using Langmuir Isotherm. Paracetamol adsorption was 96.6 % at charcoal-drug ratio (6:1) while only 2 % higher in 8:1 and 2.9 % in 10:1. The binding constant (K2), maximum adsorption capacity per gram of activated charcoal for paracetamol alone and in presence of dextropropoxyphene hydrochloride, N-acetylcysteine and sorbitol was found to be 366, 339, 313 and 355 mg/g, respectively. The results of the present study indicate that except sorbitol other investigated substances significantly reduce the adsorption of paracetamol on activated charcoal, which may be compensated by increasing the concentration of activated charcoal.Colegio de Farmacéuticos de la Provincia de Buenos Aire

Parametric analysis of turning HSLA steel under minimum quantity lubrication (MQL) and nanofluids-based minimum quantity lubrication (NF-MQL) : a concept of one-step sustainable machining

Abstract: The requirement of cost-effective and ecological production systems is crucial in the competitive market. In this regard, the focus is shifted towards sustainable and cleaner machining processes. Besides the clean technologies, effective parametric control is required for machining materials (such as High Strength Low Alloy Steels) specifically designed for high strength applications having superior physio-chemical properties. Therefore, the machinability complexities require optimized solutions to reduce temperature elevation and tooling costs and improve machining of these materials. Complying to the market needs, this research examines the effectiveness of nanofluid on tool life, wear mechanisms, surface roughness (Ra), surface morphology, and material removal rate (MRR) in turning of 30CrMnSiA (HSLA) using minimum quantity lubrication (MQL) and SiO2-H2O nanofluids (NF-MQL). A systematic investigation based on physical phenomena involved is carried out considering four process parameters (cutting speed (VC), feed rate (Fr), depth of cut (DOC), and mode of lubrication for machining. Fr is found as the vital parameter for surface roughness while MRR is highly influenced by DOC regardless of lubrication approach. One-step sustainability technique is applied, in which process variables used for roughing conditions are analogous to attain surface comparable to finished machining without compromising process efficiency and demonstrate its feasibility through optimal settings under NF-MQL. Multi-response optimization proved the NF-MQL machining condition as the best alternative which result in 28.34% and 5.09% improvements for surface roughness and MRR, respectively. Moreover, the use of SiO2 is recommended over MQL due to lower energy consumption, low tool wear, and better surface integrity, sustainable liquid, and related costs