New flavonoids from the Saudi Arabian plant:Retama raetam which stimulates secretion of insulin and inhibits α-glucosidase

Retama raetam is a bush which is a member of the family Fabaceae. It is used traditionally in North Africa and Saudi Arabia for the treatment of diabetes. Several flavonoids and alkaloids are already known from this plant. Chromatographic fractionation and purification led to the isolation of three new derivatives of prenylated flavones, retamasin C-E, and four new derivatives of prenylated isoflavones, retamasin F-I, in addition to two isoflavones which have not been previously reported in this plant. Particularly interesting structures included isoflavones containing 3,5-dihydro-2H-2,5-methanobenzo[e][1,4]dioxepine and 3a,8b-dihydro-7-hydroxyfuro[3,2-b]benzo[2,1-d]furan units, both of which are new amongst natural product flavonoids. Five new examples (two flavones and three isoflavones) strongly enhanced the glucose-triggered release of insulin by murine pancreatic islets and one isoflavone was a potent inhibitor of α-glucosidase. This study may rationalise the traditional medicinal use of R. raetam and provide new leads for drug design in the treatment of diabetes.</p

Stimulation of insulin secretion by 5-methylcoumarins and its sulfur analogues isolated from Clutia lanceolata Forssk

Clutia lanceolata Forssk. (C. lanceolata) is a medicinal plant native to sub-Saharan Africa and the Arabian Peninsula. Phytochemical investigation of the aerial parts of C. lanceolata yielded twenty-one coumarins including methylthio and methylsulfinyl-coumarins. Thirteen of these compounds are reported here for the first time, named as cluteolin A to M. The remaining eight compounds are known but have not been associated previously with C. lanceolata. The structures of the undescribed compounds were elucidated from their 2D NMR and MS spectra. Single crystal X-ray analyses confirmed the structures of eleven compounds. As, in Saudi Arabian tradition, C. lanceolata has been reported to have anti-diabetic and anti-fungal properties, the coumarins were examined for their biological activity. Seven compounds strongly enhanced the glucose-triggered release of insulin by murine pancreatic islets, with two compounds showing more than two-fold enhancement of insulin secretion, compared with the standard drug glimepiride

Microspore-derived embryos of Brassica napas L.: stress tolerance and embryo development

Bibliography: p. 164-182

Pathways of Climate-Resilient Health Systems in Bangladesh

Climate change is a complex phenomenon that will have a range of both anticipated and unexpected direct and indirect effects. The IPCC Fifth Assessment Report (AR5) affirms that recent decades have seen warming air and ocean temperatures, changing rainfall patterns, variations in the frequency and intensity of several extreme events including droughts, floods and storms and rising sea levels. The changing climate will adversely affect the health of human populations. These include primary or direct effects (e.g. increased deaths due to extreme weather events like cyclones); secondary or indirect effects (e.g. increased health problems due to disease vectors, such as malaria-carrying mosquitos and contaminated food and water); and tertiary or long-term effects (e.g. distractions for health and social services). This chapter provides an introduction to the relationship between climate change and human health, using the country-specific example of Bangladesh. Bangladesh is a low-lying country in which extreme climatic events are a common phenomenon. With the objective of providing an overview of the likely health impacts caused by climate change, the chapter examines the relationship between three distinct climatic events – flooding, salinity intrusion and drought – in relation to human health. In Bangladesh, issues such as poor water quality, unhygienic environmental conditions and poor sanitation, exacerbate the impact of climate-sensitive diseases (diseases of which transmission is linked to climatic and weather conditions). This chapter provides a foundation for studying the relationship between the climatic characteristics of the study area, climate-sensitive diseases and other anthropogenic phenomena. It demonstrates the pathways of climate-resilient health systems in Bangladesh

Assessing demographic and economic vulnerabilities to sea level rise in Bangladesh via a nighttime light-based cellular automata model

Abstract The Intergovernmental Panel on Climate Change (IPCC) 6th Assessment Report (AR6) forecasts a sea level rise (SLR) of up to 2 m by 2100, which poses significant risks to regional geomorphology. As a country with a rapidly developing economy and substantial population, Bangladesh confronts unique challenges due to its extensive floodplains and 720 km-long Bay of Bengal coastline. This study uses nighttime light data to investigate the demographic repercussions and potential disruptions to economic clusters arising from land inundation attributable to SLR in the Bay of Bengal. By using geographical information system (GIS)-based bathtub modeling, this research scrutinizes potential risk zones under three selected shared socioeconomic pathway (SSP) scenarios. The analysis anticipates that between 0.8 and 2.8 thousand km2 of land may be inundated according to the present elevation profile, affecting 0.5–2.8 million people in Bangladesh by 2150. Moreover, artificial neural network (ANN)-based cellular automata modeling is used to determine economic clusters at risk from SLR impacts. These findings emphasize the urgency for land planners to incorporate modeling and sea inundation projections to tackle the inherent uncertainty in SLR estimations and devise effective coastal flooding mitigation strategies. This study provides valuable insights for policy development and long-term planning in coastal regions, especially for areas with a limited availability of relevant data

A low hop distance hierarchical interconnection network

In this paper, we have proposed a new hierarchical interconnection network called Tori-connected Flattened Butterfly Network (TFBN). It is a hierarchical interconnection network which is able to interconnect millions of nodes in the network to achieve high performance and cost-effective design for massively parallel computing system. TFBN consists of multiple basic modules of flattened butterfly network whereby the basic modules are connected using 2D-torus network. This paper focuses on the architecture of the TFBN and the evaluation of its static network performance such as degree, diameter, cost, average distance, arc connectivity, bisection width and wiring complexity. The comparison of performance shows better performance in terms of distance parameters as well as other parameters

Water and bottom sediments quality of brackish water shrimp farms in Kaliganj Upazila, Satkhira, Bangladesh

Shrimp culture plays a central part in the fisheries sector of Bangladesh that leads to a significant change in the structure and composition of frozen food export sector. An investigation was carried out to determine physiochemical parameters, nutrients content, bacterial contamination and metal content in shrimp “Gher” (Farms) water and sediments. Physicochemical parameters were analyzed in situ by portable meters. Ammonia, phosphate, bacterial counts, and metals contents were analyzed by Nesslerization, colorimetric and standard microbiological methods and Atomic Absorption Spectrophotometery (AAS), respectively. Except Dissolve oxygen and temperature all other physiochemical parameters were unsuitable for shrimp culture. The concentration of ammonia was 0.384 to 1.5 mg L-1 and the concentration of phosphate ranged from 0.02 to 0.818 mg L-1. In bacteriological analysis, highest levels of coliform were found in the tested samples and total colifom count reached up to 2.04x103 cfu mL-1. Among the tested metals, Cr was highest in water and sediment samples. Concentration of Cr ranged from 0.150 to 0.807 mg L-1 and 1.957 to 3.436 mg kg-1 in water and sediment samples, respectively. A significant difference was observed for the concentration of metals in sediment and water samples. The high concentration of nutrients and metals in shrimp “Gher” water and sediment as well as the presence of pathogenic bacteria in the “Gher” and river water indicated unhygienic environment and the sources of contamination of shrimp “Gher”

Suppressive Effects of Clerodendrum volubile P Beauv. [Labiatae] Methanolic Extract and Its Fractions on Type 2 Diabetes and Its Complications

Type 2 diabetes is the most prominent of all diabetes types, contributing to global morbidity and mortality. Availability and cost of treatment with little or no side effect especially in developing countries, remains a huge burden. This has led to the search of affordable alternative therapies especially from medicinal plants. In this study, the antidiabetic effect of the methanolic extract, dichloromethane (DCM), butanol (BuOH) and aqueous fractions of Clerodendrum volubile leaves were investigated in type 2 diabetic rats for their effect on glucose homeostasis, serum insulin level and hepatic biomarkers, lipid profile, pancreatic redox balance and Ca2+ levels, and β-cell distribution and function. The DCM was further fractionated to isolate the active compounds, biochanin and 5,7,4′-trimethoxykaempferol. They were investigated for their toxicity and ADMET properties, α-glucosidase and angiotensin I converting enzyme (ACE) inhibitory activities in silico. There were significant (p &lt; 0.05) decrease in blood glucose, cholesterol, LDL-C, vLDL-C, triglyceride, AST and ALT levels in all treated groups, with DCM fraction showing the best activity. All treated rats showed significantly (p &lt; 0.05) improved anti-oxidative activities. Treatment with the DCM fraction led to significant (p &lt; 0.05) increased serum insulin and pancreatic Ca2+ levels, as well as improved β-cell distribution and function. DCM fraction also showed improved glucose tolerance. DCM fraction dose-dependently inhibited ACE activity. The toxicity class of the isolated compounds was predicted to be 5. They were also predicted to be potent inhibitors of cytochrome P (CYPs) 1A2, 2D6 and 3A4. They docked well with α-glucosidase and ACE. These results indicate the therapeutic potential of the plant against type 2 diabetes, with the DCM fraction being the most potent which may be attributed to the isolated flavones. It further suggests antihypertensive potentials of the DCM fraction. However, inhibition of CYPs by the flavones may suggest caution in usage with other prescribed drugs metabolized by these enzymes

The incidence of hypoglycemia among insulin-treated patients with Type 1 or Type 2 diabetes: Bangladeshi cohort of international operations-hypoglycemia assessment tool study

Objectives: The objective of this study was to assess the incidence of hypoglycemia in patients with type 1 diabetes mellitus (T1DM) or type 2 diabetes mellitus (T2DM) in Bangladeshi cohort of the International Operations-Hypoglycemia Assessment Tool study. Materials and Methods: Patients diagnosed with either T1DM or T2DM, aged ≥18 years, treated with insulin (any regimen) for >12 months, and completed self-assessment questionnaires (SAQs) to record demography, treatment information, and hypoglycemia during the 6-month retrospective and 4-week prospective periods (a total of 7 months) were enrolled in the study. Results: A total of 1179 patients were enrolled and completed the SAQ1 (T1DM, n = 25; T2DM, n = 1154). Almost all patients (T1DM: 100.0% [95% confidence interval (CI): 86.3%, 100.0%] and T2DM: 97.0% [95% CI: 95.9%, 97.9%]) experienced at least 1 hypoglycemic event prospectively. The estimated rates of any and severe hypoglycemia were 26.6 (95% CI: 19.8, 35.0) and 14.1 (95% CI: 9.3, 20.4) events per patient-per year (PPY), respectively, for patients with T1DM and 18.3 (95% CI: 17.4, 19.2) and 12.1 (95% CI: 11.4, 12.9) events PPY, respectively, for patients with T2DM during the prospective period. At baseline, mean glycated hemoglobin (HbA1c) (±standard deviation) was 8.1 (±1.8%) for T1DM and 8.8 (±1.8%) for T2DM. Hypoglycemic rate was independent of HbA1c levels and types of insulin. Conclusions: This is the first patient dataset of self-reported hypoglycemia in Bangladesh; results confirm that hypoglycemia is underreported