A new isoquinoline alkaloid with anti-microbial properties from <i>Berberis jaeschkeana</i> Schneid. var. <i>jaeschkeana</i>

<div><p>One new isoquinoline alkaloid named berberidione <b>(1)</b> along with four new source alkaloids berberine <b>(2)</b>, palmatine <b>(3)</b>, jatrorrhizine <b>(4)</b> and chondrofoline <b>(5)</b> and three new source non-alkaloids syringic acid <b>(6)</b>, β-sitosterol <b>(7)</b> and stigmasterol <b>(8)</b> was isolated and characterised from different fractions of <i>Berberis jaeschkeana</i> Schneid var. <i>jaeschkeana</i>. All the structures were determined from 1D and 2D spectroscopic data. Crude extract, sub-fractions and isolated compounds showed excellent anti-microbial properties. The toxicity level for the alkaloids was found to be very low on THP-1 cells.</p></div

Isolation, structure elucidation and enzyme inhibition studies of a new hydroxy ester and other compounds from <i>Berberis jaeschkeana</i> Schneid stem

<div><p>Bioassay-guided isolation and fractionation of <i>Berberis jaeschkeana</i> Schneid var. <i>jaeschkeana</i> stem resulted in the isolation and characterisation of a new long chain hydroxy ester named as berberinol (<b>1</b>) along with six known compounds (<b>2</b>–<b>7</b>). All the structures were established from 1D and 2D spectroscopic data. Crude extract, sub-fractions and all the isolated compounds were evaluated for their anti-fungal and urease enzyme inhibition properties. All of the sub-fractions and compounds showed good anti-fungal and urease enzyme inhibition properties. Minimum inhibitory concentrations (MICs) were calculated for all active samples in case of urease enzyme inhibition. MICs values were found to be in the range of 39.03–49.78 μg/mL for urease enzyme inhibition.</p></div

A new irregular monoterpene acetate along with eight known compounds with antifungal potential from the aerial parts of <i>Artemisia incisa</i> Pamp (Asteraceae)

<p>A new compound named as santolinylol-3-acetate (4-(2-hydroxypropan-2-yl)-2-methylhexa-1,5-dien-3-yl acetate) (<b>3</b>), along with seven known compounds; linoleic acid (<b>1</b>), benzoic acid (<b>2</b>), santolinylol (<b>4</b>), ethyl-(<i>E</i>)-<i>p</i>-hydroxy cinnamate (<b>5</b>), scopoletin (<b>6</b>), esculetin (<b>7</b>) isofraxidin (<b>8</b>) and eupatorin (<b>9</b>), were isolated from the aerial parts (ethanolic extract) of endangered species: <i>Artemisia incisa</i> Pamp (Asteraceae). The compounds’ structures were determined through modern spectroscopic techniques, and comparison of data (physicochemical constants) with the literature. The relative stereochemistry of santolinylol-3-acetate (<b>3</b>) was determined by comparing its data of NOESY, and specific rotation with its diol analogue; santolinylol (<b>4</b>), isolated from the same plant; <i>A. incisa</i>. The results of the antifungal activity showed that coumarins are as whole less active compounds. Compounds <b>3</b> (25 and 300 μg/mL), and <b>4</b> (12.5 and 300 μg/mL), showed good activities against <i>Candida albicans</i>, and <i>Aspergillus flavus</i>, respectively, which justifies <i>A. incisa</i> as a traditional medicine for curing the said fungal infections.</p> <p>Irregular monoterpene activity against Candida albicans infection.</p