<div><p>One new isoquinoline alkaloid named berberidione <b>(1)</b> along with four new source alkaloids berberine <b>(2)</b>, palmatine <b>(3)</b>, jatrorrhizine <b>(4)</b> and chondrofoline <b>(5)</b> and three new source non-alkaloids syringic acid <b>(6)</b>, β-sitosterol <b>(7)</b> and stigmasterol <b>(8)</b> was isolated and characterised from different fractions of <i>Berberis jaeschkeana</i> Schneid var. <i>jaeschkeana</i>. All the structures were determined from 1D and 2D spectroscopic data. Crude extract, sub-fractions and isolated compounds showed excellent anti-microbial properties. The toxicity level for the alkaloids was found to be very low on THP-1 cells.</p></div
