Proliferative actinic keratosis: An invasive squamous cell carcinoma or not?

Actinic keratoses have variants that differ clinically and pathologically. Proliferative actinic keratoses (PAK) are known to be resistant against standard therapies and to create a tendency for the development of invasive squamous cell carcinoma (SCC). This study retrospectively reviewed the medical records of 50 patients with 51 PAK lesions. Fifty patients (40 male, 10 female) with a mean age of 68.5 were included in the study. Thirty-two (63%) PAK lesions were clinically selected for total excision but only 27 of them could be totally excised. Among the excised lesions, 13 were reported to be PAK, 13 were SCC, and 1 was keratoacanthoma. There was no significant difference between the PAK and SCC groups. Overall, the groups with excised and unexcised lesions were statistically similar with respect to age, sex, lesion duration, localization, size, and surface features, but induration was more common in the SCC group. The mean follow-up time was 19.7 and 17.0 months in the PAK and SCC group, respectively. In conclusion, 25% (13/51) of lesions diagnosed as PAK were invasive SCC, which is of clinical and histopathological significance. Our results suggest that the definition of PAK should be histopathologically revised and that total excisional biopsy instead of punch biopsy should be considered, especially for lesions with a proliferative appearance. </p

Association between biophysical properties and anxiety in patients with sensitive skin

Background: Sensitive skin (SS) is a syndrome in which neurosensory disorders accompany epidermal barrier dysfunction. However, it is not yet clear how high anxiety levels affect the biophysical parameters of the skin in patients with SS

Solitary noninfiltrating angiolipoma on the finger, an unusual localization.

Angiolipoma, a subtype of lipoma, is a benign adypocytic soft tissue tumor composed of mature adipose tissue and small vascular proliferations. This entity makes up 5–17% of all lipomas. The diagnosis is made by clinical and pathological examination, ultrasonography, and/or magnetic resonance imaging (MRI). It is generally an encapsulated tumor (noninfiltrative), but rarely has an infiltrative form. Angiolipoma mostly occurs on the trunk and extremities with male predominance. The forearm is the most frequent location for angiolipomas. It is very rarely seen on the fingers. Herein, we report a patient with solitary noninfiltrating angiolipoma on a finger. The patient was treated with surgical excision and no recurrence has been noted over one year of observation

Evaluation of quality of life in female patients with melasma

Melasma is an acquired pigmentation disease occurs on the face and neck, sun-exposed areas. It significantly affects the quality of life of the patients. The objective of this study was to evaluate the quality of life in patients with melasma. A prospective cross-sectional study was conducted on 49 female patients diagnosed with melasma between November 2016 and March 2017 in a tertiary referral hospital dermatology outpatient clinic. The patients were evaluated according to age, marital status, education level, Fitzpatrick skin type, puberty age, the duration of disease, family history, medical comorbidities. Disease severity were measured with the melasma area and severity index (MASI). The patients were evaluated according to quality of life scales: Turkish version of the melasma quality-of-life questionnaire (MelasQoL-TR), Dermatology Life Quality Index (DLQI), Turkish version of Skindex 16. The correlation between the severity of the disease and the qualities of life of the patients were evaluated. Fourty-nine female patients with the mean age of 36.8 ± 7.8 enrolled in the study. Fitzpatrick skin type III (49.6%) and IV (49.0%) were the most common skin phototypes. The mean disease duration was 56.7 ± 49.0 months. The mean MASI score was 16.3 ± 8.7. The mean MeLaSQoL-TR score, DLQI score and Skindex 16 score were 34.4 ± 13.0, 15.1 ± 7.6, 34,7 ± 16,9 respectively. Significant positive correlation was found between MASI score and MelasQoL-TR, DLQI and Skindex 16 scores (p &#706; 0.05). When the scores of emotion and function of Skindex 16 were evaluated separately, there was a significant positive correlation between MASI score and these scores (p &#706; 0.05). However no significant correlation was observed between MASI score and Skindex 16 symptom score (p &#707; 0.05). There was a significant correlation between these three different life quality scales. Age and education level were not significantly related with quality of life scales in our study. In this study, all scale scores were high in patients with melasma, and were correlated with severity of the disease. Melasma has a significant emotional and functional impact on quality of life in female patients. [Med-Science 2020; 9(2.000): 347-51

Proliferative actinic keratosis: An invasive squamous cell carcinoma or not?

Actinic keratoses have variants that differ clinically and pathologically. Proliferative actinic keratoses (PAK) are known to be resistant against standard therapies and to create a tendency for the development of invasive squamous cell carcinoma (SCC). This study retrospectively reviewed the medical records of 50 patients with 51 PAK lesions. Fifty patients (40 male, 10 female) with a mean age of 68.5 were included in the study. Thirty-two (63%) PAK lesions were clinically selected for total excision but only 27 of them could be totally excised. Among the excised lesions, 13 were reported to be PAK, 13 were SCC, and 1 was keratoacanthoma. There was no significant difference between the PAK and SCC groups. Overall, the groups with excised and unexcised lesions were statistically similar with respect to age, sex, lesion duration, localization, size, and surface features, but induration was more common in the SCC group. The mean follow-up time was 19.7 and 17.0 months in the PAK and SCC group, respectively. In conclusion, 25% (13/51) of lesions diagnosed as PAK were invasive SCC, which is of clinical and histopathological significance. Our results suggest that the definition of PAK should be histopathologically revised and that total excisional biopsy instead of punch biopsy should be considered, especially for lesions with a proliferative appearance. </p