535 research outputs found
Instanton propagator and instanton induced processes in scalar model
The propagator in the instanton background in the
scalar model in four dimensions is studied.Leading and sub-leading terms of its
asymptotics for large momenta and its on-shell double residue are calculated
analytically. These results are applied to the analysis of the initial-state
and initial-final-state corrections and the calculation of the next-to-leading
(propagator) correction to the exponent of the cross section of instanton
induced multiparticle scattering processes.Comment: 44 pages, 7 postscript figures, LaTe
Varied Signature Splitting Phenomena in Odd Proton Nuclei
Varied signature splitting phenomena in odd proton rare earth nuclei are
investigated. Signature splitting as functions of and in the angular
momentum projection theory is explicitly shown and compared with those of the
particle rotor model. The observed deviations from these rules are due to the
band mixings. The recently measured Ta high spin data are taken as a
typical example where fruitful information about signature effects can be
extracted. Six bands, two of which have not yet been observed, were calculated
and discussed in detail in this paper. The experimentally unknown band head
energies are given
Characterization and application of two RANK-specific antibodies with different biological activities.
Antibodies play an important role in therapy and investigative biomedical research. The TNF-family member Receptor Activator of NF-κB (RANK) is known for its role in bone homeostasis and is increasingly recognized as a central player in immune regulation and epithelial cell activation. However, the study of RANK biology has been hampered by missing or insufficient characterization of high affinity tools that recognize RANK. Here, we present a careful description and comparison of two antibodies, RANK-02 obtained by phage display (Newa, 2014 [1]) and R12-31 generated by immunization (Kamijo, 2006 [2]). We found that both antibodies recognized mouse RANK with high affinity, while RANK-02 and R12-31 recognized human RANK with high and lower affinities, respectively. Using a cell apoptosis assay based on stimulation of a RANK:Fas fusion protein, and a cellular NF-κB signaling assay, we showed that R12-31 was agonist for both species. R12-31 interfered little or not at all with the binding of RANKL to RANK, in contrast to RANK-02 that efficiently prevented this interaction. Depending on the assay and species, RANK-02 was either a weak agonist or a partial antagonist of RANK. Both antibodies recognized human Langerhans cells, previously shown to express RANK, while dermal dendritic cells were poorly labeled. In vivo R12-31 agonist activity was demonstrated by its ability to induce the formation of intestinal villous microfold cells in mice. This characterization of two monoclonal antibodies should now allow better evaluation of their application as therapeutic reagents and investigative tools
Strings in Homogeneous Background Spacetimes
The string equations of motion for some homogeneous (Kantowski-Sachs, Bianchi
I and Bianchi IX) background spacetimes are given, and solved explicitly in
some simple cases. This is motivated by the recent developments in string
cosmology, where it has been shown that, under certain circumstances, such
spacetimes appear as string-vacua.
Both tensile and null strings are considered. Generally, it is much simpler
to solve for the null strings since then we deal with the null geodesic
equations of General Relativity plus some additional constraints.
We consider in detail an ansatz corresponding to circular strings, and we
discuss the possibility of using an elliptic-shape string ansatz in the case of
homogeneous (but anisotropic) backgrounds.Comment: 25 pages, REVTE
Singularities In Scalar-Tensor Cosmologies
In this article, we examine the possibility that there exist special
scalar-tensor theories of gravity with completely nonsingular FRW solutions.
Our investigation in fact shows that while most probes living in such a
Universe never see the singularity, gravity waves always do. This is because
they couple to both the metric and the scalar field, in a way which effectively
forces them to move along null geodesics of the Einstein conformal frame. Since
the metric of the Einstein conformal frame is always singular for
configurations where matter satisfies the energy conditions, the gravity wave
world lines are past inextendable beyond the Einstein frame singularity, and
hence the geometry is still incomplete, and thus singular. We conclude that the
singularity cannot be entirely removed, but only be made invisible to most, but
not all, probes in the theory.Comment: 23 pages, latex, no figure
Donor states in modulation-doped Si/SiGe heterostructures
We present a unified approach for calculating the properties of shallow
donors inside or outside heterostructure quantum wells. The method allows us to
obtain not only the binding energies of all localized states of any symmetry,
but also the energy width of the resonant states which may appear when a
localized state becomes degenerate with the continuous quantum well subbands.
The approach is non-variational, and we are therefore also able to evaluate the
wave functions. This is used to calculate the optical absorption spectrum,
which is strongly non-isotropic due to the selection rules. The results
obtained from calculations for Si/SiGe quantum wells allow us to
present the general behavior of the impurity states, as the donor position is
varied from the center of the well to deep inside the barrier. The influence on
the donor ground state from both the central-cell effect and the strain arising
from the lattice mismatch is carefully considered.Comment: 17 pages, 10 figure
Dimensionless cosmology
Although it is well known that any consideration of the variations of
fundamental constants should be restricted to their dimensionless combinations,
the literature on variations of the gravitational constant is entirely
dimensionful. To illustrate applications of this to cosmology, we explicitly
give a dimensionless version of the parameters of the standard cosmological
model, and describe the physics of Big Bang Neucleosynthesis and recombination
in a dimensionless manner. The issue that appears to have been missed in many
studies is that in cosmology the strength of gravity is bound up in the
cosmological equations, and the epoch at which we live is a crucial part of the
model. We argue that it is useful to consider the hypothetical situation of
communicating with another civilization (with entirely different units),
comparing only dimensionless constants, in order to decide if we live in a
Universe governed by precisely the same physical laws. In this thought
experiment, we would also have to compare epochs, which can be defined by
giving the value of any {\it one} of the evolving cosmological parameters. By
setting things up carefully in this way one can avoid inconsistent results when
considering variable constants, caused by effectively fixing more than one
parameter today. We show examples of this effect by considering microwave
background anisotropies, being careful to maintain dimensionlessness
throughout. We present Fisher matrix calculations to estimate how well the fine
structure constants for electromagnetism and gravity can be determined with
future microwave background experiments. We highlight how one can be misled by
simply adding to the usual cosmological parameter set
COMMISSION OF THE EUROPEAN COMMUNITIES. Draft DECISION OF THE REPRESENTATIVES OF THE GOVERNMENTS OF THE MEMBER STATES OF THE EUROPEAN COAL AND STEEL COMMUNITY. MEETING WITHIN THE COUNCIL. modifying Decision 92/470/ECSC concerning certain technical modalities in connection with the application of Decision 92/285/ECSC prohibiting trade between the European Coal and Steel Community and the Republics of Serbia and Montenegro. Proposal for a COUNCIL REGULATION (EEC) modifying Regulation (EEC) No 2656/92 concerning certain technical modalities in connection with the application of Regulation (EEC) No 1432/92 prohibiting trade between the European Economic Community and the Republics of Serbia and Montenegro (presented by the Commission). COM (92) 485 final, 18 December 1992
Snipe taxonomy based on vocal and non-vocal sound displays: the South American Snipe is two species
We analysed breeding sounds of the two subspecies of South American Snipe Gallinago paraguaiae paraguaiae and Gallinago paraguaiae magellanica to determine whether they might be different species: loud vocalizations given on the ground, and the tail‐generated Winnow given in aerial display. Sounds of the two taxa differ qualitatively and quantitatively. Both taxa utter two types of ground call. In G. p. paraguaiae, the calls are bouts of identical sound elements repeated rhythmically and slowly (about five elements per second (Hz)) or rapidly (about 11 Hz). One call of G. p. magellanica is qualitatively similar to those of G. p. paraguaiae but sound elements are repeated more slowly (about 3 Hz). However, its other call type differs strikingly: it is a bout of rhythmically repeated sound couplets, each containing two kinds of sound element. The Winnow of G. p. paraguaiae is a series of sound elements that gradually increase in duration and energy; by contrast, that of G. p. magellanica has two or more kinds of sound element that roughly alternate and are repeated as sets, imparting a stuttering quality. Sounds of the related Puna Snipe (Gallinago andina) resemble but differ quantitatively from those of G. p. paraguaiae. Differences in breeding sounds of G. p. paraguaiae and G. p. magellanica are strong and hold throughout their geographical range. Therefore we suggest that the two taxa be considered different species: G. paraguaiae east of the Andes in much of South America except Patagonia, and G. magellanica in central and southern Chile, Argentina east of the Andes across Patagonia, and Falklands/Malvinas.Fil: Miller, Edward H.. Memorial University Of Newfoundland; CanadáFil: Areta, Juan Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Bio y Geociencias del NOA. Universidad Nacional de Salta. Facultad de Ciencias Naturales. Museo de Ciencias Naturales. Instituto de Bio y Geociencias del NOA; ArgentinaFil: Jaramillo, Alvaro. San Francisco Bay Bird Observatory; Estados UnidosFil: Imberti, Santiago. Asociación Ambiente Sur, Rio Gallegos; ArgentinaFil: Matus, Ricardo. Kilómetro 7 Sur; Chil
Workflow and Tools for Crystallographic Fragment Screening at the Helmholtz Zentrum Berlin
Fragment screening is a technique that helps to identify promising starting points for ligand design. Given that crystals of the target protein are available and display reproducibly high resolution X ray diffraction properties, crystallography is among the most preferred methods for fragment screening because of its sensitivity. Additionally, it is the only method providing detailed 3D information of the binding mode of the fragment, which is vital for subsequent rational compound evolution. The routine use of the method depends on the availability of suitable fragment libraries, dedicated means to handle large numbers of samples, state of the art synchrotron beamlines for fast diffraction measurements and largely automated solutions for the analysis of the results. Here, the complete practical workflow and the included tools on how to conduct crystallographic fragment screening CFS at the Helmholtz Zentrum Berlin HZB are presented. Preceding this workflow, crystal soaking conditions as well as data collection strategies are optimized for reproducible crystallographic experiments. Then, typically in a one to two day procedure, a 96 membered CFS focused library provided as dried ready to use plates is employed to soak 192 crystals, which are then flash cooled individually. The final diffraction experiments can be performed within one day at the robot mounting supported beamlines BL14.1 and BL14.2 at the BESSY II electron storage ring operated by the HZB in Berlin Adlershof Germany . Processing of the crystallographic data, refinement of the protein structures, and hit identification is fast and largely automated using specialized software pipelines on dedicated servers, requiring little user input. Using the CFS workflow at the HZB enables routine screening experiments. It increases the chances for successful identification of fragment hits as starting points to develop more potent binders, useful for pharmacological or biochemical application
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