454 research outputs found
Superconducting transition of a two-dimensional Josephson junction array in weak magnetic fields
The superconducting transition of a two-dimensional (2D) Josephson junction
array exposed to weak magnetic fields has been studied experimentally.
Resistance measurements reveal a superconducting-resistive phase boundary in
serious disagreement with the theoretical and numerical expectations. Critical
scaling analyses of the characteristics indicate contrary to the
expectations that the superconducting-to-resistive transition in weak magnetic
fields is associated with a melting transition of magnetic-field-induced
vortices directly from a pinned-solid phase to a liquid phase. The expected
depinning transition of vortices from a pinned-solid phase to an intermediate
floating-solid phase was not observed. We discuss effects of the
disorder-induced random pinning potential on phase transitions of vortices in a
2D Josephson junction array.Comment: 9 pages, 7 figures (EPS+JPG format), RevTeX
Superconducting phase transitions in frustrated Josephson-junction arrays on a dice lattice
Transport measurements are carried out on dice Josephson-junction arrays with
the frustration index and 1/2 which possess, within the limit of the
model, an accidental degeneracy of the ground states as a consequence of
the formation of zero-energy domain walls. The measurements demonstrate that
both the systems undergo a phase transition to a superconducting vortex-ordered
state at considerably high temperatures. The experimental findings are in
apparent contradiction with the theoretical expectation that frustration
effects in the system are particularly strong enough to suppress a
vortex-ordering transition down to near zero temperature. The data for
are more consistent with theoretical evaluations. The agreement between the
experiments and the Monte Carlo simulations of a model for
suggests that the order-from-disorder mechanism for the removal of an
accidental degeneracy may still be effective in the system. The
transport data also reveal that the dice arrays with zero-energy domain walls
experience a much slower critical relaxation than other frustrated arrays only
with finite-energy walls.Comment: 4 pages, 4 figure
Unusual T_c variation with hole concentration in Bi_2Sr_{2-x}La_xCuO_{6+\delta}
We have investigated the variation with the hole concentration in
the La-doped Bi 2201 system, BiSrLaCuO. It is
found that the Bi 2201 system does not follow the systematics in and
observed in other high- cuprate superconductors (HTSC's). The vs
characteristics are quite similar to what observed in Zn-doped HTSC's. An
exceptionally large residual resistivity component in the inplane resistivity
indicates that strong potential scatterers of charge carriers reside in CuO
planes and are responsible for the unusual variation with , as in the
Zn-doped systems. However, contrary to the Zn-doped HTSC's, the strong scatter
in the Bi 2201 system is possibly a vacancy in the Cu site.Comment: RevTeX, 3 figures, to be published in the Physical Review
Frustrated two-dimensional Josephson junction array near incommensurability
To study the properties of frustrated two-dimensional Josephson junction
arrays near incommensurability, we examine the current-voltage characteristics
of a square proximity-coupled Josephson junction array at a sequence of
frustrations f=3/8, 8/21, 0.382 , 2/5, and 5/12.
Detailed scaling analyses of the current-voltage characteristics reveal
approximately universal scaling behaviors for f=3/8, 8/21, 0.382, and 2/5. The
approximately universal scaling behaviors and high superconducting transition
temperatures indicate that both the nature of the superconducting transition
and the vortex configuration near the transition at the high-order rational
frustrations f=3/8, 8/21, and 0.382 are similar to those at the nearby simple
frustration f=2/5. This finding suggests that the behaviors of Josephson
junction arrays in the wide range of frustrations might be understood from
those of a few simple rational frustrations.Comment: RevTex4, 4 pages, 4 eps figures, to appear in Phys. Rev.
Critical Behavior of Frustrated Josephson Junction Arrays with Bond Disorder
The scaling behavior of the current-voltage () characteristics of a
two-dimensional proximity-coupled Josephson junction array (JJA) with quenched
bond disorder was investigated for frustrations , 1/3, 2/5, and 1/2. For
all these frustrations including 1/5 and 2/5 where a strongly first-order phase
transition is expected in the absence of disorder, the characteristics
exhibited a good scaling behavior. The critical exponent indicates that
bond disorder may drive the phase transitions of frustrated JJA's to be
continuous but not into the Ising universality class, contrary to what was
observed in Monte Carlo simulations. The dynamic critical exponent for
JJA's was found to be only 0.60 - 0.77.Comment: RevTeX4, 4 pages, 4 figures, the manuscript is replaced with the
published versio
Directions for and prospects of the Environmental Health Study in Korean National Industrial Complexes (EHSNIC): A proposal for the third phase of the EHSNIC
The Environmental Health Study in the Korean National Industrial Complexes (EHSNIC) is a project that aims to monitor the exposure and health effects of environmental pollution among residents of national industrial complexes, as well as propose appropriate environmental health measures. Since its launch in 2003, this project has been initiated in eight national industrial complexes. Currently, it is necessary to review the accomplishments and limitations of the phases 1 and 2 of this project, and establish the direction of the upcoming the phase 3. Thus, the present study has developed principles and goals for the phase 3, considering the rationale and justification of the EHSNIC, and presented specific research contents accordingly. In the phase 3, it is important to improve the methods for exposure assessment and evaluation of health effects, in order to identify clearly the association between the pollutants released from industrial complexes and their health impacts, to develop and to reinforce communication strategies to promote participation of residents of communities near industrial complexes. Nonetheless, it is also important to maintain the basic goal of continuously monitoring the level of exposure to and health effects of environmental pollutants
Thermal Conductivity of superconducting (TMTSF)_2ClO_4: evidence for a nodeless gap
We report on the first measurements of thermal conductivity in the
superconducting state of (TMTSF)_2ClO_4. The electronic contribution to heat
transport is found to decrease rapidly below T_c, indicating the absence of
low-energy electronic excitations. We argue that this result provides strong
evidence for a nodeless superconducting gap function but does not exclude a
possible unconventional order parameter.Comment: 4 pages including 4 figures, submitted to Phys. Rev. Let
Pharmacogenomic profiling reveals molecular features of chemotherapy resistance in IDH wild-type primary glioblastoma
Background
Although temozolomide (TMZ) has been used as a standard adjuvant chemotherapeutic agent for primary glioblastoma (GBM), treating isocitrate dehydrogenase wild-type (IDH-wt) cases remains challenging due to intrinsic and acquired drug resistance. Therefore, elucidation of the molecular mechanisms of TMZ resistance is critical for its precision application.
Methods
We stratified 69 primary IDH-wt GBM patients into TMZ-resistant (n = 29) and sensitive (n = 40) groups, using TMZ screening of the corresponding patient-derived glioma stem-like cells (GSCs). Genomic and transcriptomic features were then examined to identify TMZ-associated molecular alterations. Subsequently, we developed a machine learning (ML) model to predict TMZ response from combined signatures. Moreover, TMZ response in multisector samples (52 tumor sectors from 18 cases) was evaluated to validate findings and investigate the impact of intra-tumoral heterogeneity on TMZ efficacy.
Results
In vitro TMZ sensitivity of patient-derived GSCs classified patients into groups with different survival outcomes (P = 1.12e−4 for progression-free survival (PFS) and 3.63e−4 for overall survival (OS)). Moreover, we found that elevated gene expression of EGR4, PAPPA, LRRC3, and ANXA3 was associated to intrinsic TMZ resistance. In addition, other features such as 5-aminolevulinic acid negative, mesenchymal/proneural expression subtypes, and hypermutation phenomena were prone to promote TMZ resistance. In contrast, concurrent copy-number-alteration in PTEN, EGFR, and CDKN2A/B was more frequent in TMZ-sensitive samples (Fishers exact P = 0.0102), subsequently consolidated by multi-sector sequencing analyses. Integrating all features, we trained a ML tool to segregate TMZ-resistant and sensitive groups. Notably, our method segregated IDH-wt GBM patients from The Cancer Genome Atlas (TCGA) into two groups with divergent survival outcomes (P = 4.58e−4 for PFS and 3.66e−4 for OS). Furthermore, we showed a highly heterogeneous TMZ-response pattern within each GBM patient usingin vitro TMZ screening and genomic characterization of multisector GSCs. Lastly, the prediction model that evaluates the TMZ efficacy for primary IDH-wt GBMs was developed into a webserver for public usage (http://www.wang-lab-hkust.com:3838/TMZEP)
Conclusions
We identified molecular characteristics associated to TMZ sensitivity, and illustrate the potential clinical value of a ML model trained from pharmacogenomic profiling of patient-derived GSC against IDH-wt GBMs
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