A Novel Microspheres Composite Hydrogels Cross-linked by Methacrylated Gelatin Nanoparticles: Enhanced Mechanical Property and Biocompatibility

Content: Nowadays, protein-based nanoparticle as a biodegradable, biocompatible product attracts considerable interest for new uses in specialized technical areas. Gelatin is a denatured, biodegradable, and nonimmunogenic protein obtained by controlled hydrolysis of the triple-helix structure of collagen into single-strain molecules. As an amphiphilic biopolymer, gelatin can easily assemble into different kinds of aggregates under the defined pH and temperature and the resulting gelatin nanoparticles have been developed to be applied in the food industry and biomedical fields. Herein we report a novel macromolecular microsphere composites (MMC) hydrogels with the use of prepared methacrylated gelatin nanoparticles (MA-GNP) as the cross-linker. MA-GNP have the ability of chemical crosslinking by the polymerization of C=C bonds, such that the composite hydrogels can be formed by radical polymerization of acrylamide (AAm) on the surface of MA-GNP. The smooth spherical particles with an average size of ~100 nm have been synthesized through a modified two-step desolvation method as proved by atomic force microscopy (AFM). The results of nuclear magnetic resonance and dynamic light scattering further confirm the presence of reactive groups (C=C bonds) in the particles and its narrow sizes distribution. The resulting composite hydrogels (MA-GNP/PAAm) are porous materials with tunable pore sizes and exhibit enhanced compressive resistance and elasticity as well. Increasing appropriately the dosage of MA-GNP reduces the equilibrium swelling ratio and improves thermal stability of the gels. Moreover, all the hydrogels exhibit prolonged blood-clotting time, nonhemolytic nature and strong suitability for cell proliferation, indicating the improved antithrombogenicity and excellent cyto-compatibility. It suggests that the novel MA-GNP/PAAm hydrogels have potential application as tissue engineer scaffold materials, and the MA-GNP can be a promising macromolecular microsphere cross-linker for application in biomedical materials. The present work not only exploits new strategies to fabricate MMC hydrogels but also advance the potential application of biodegradable gelatin-based nanoparticles in biomedical fields. Take-Away: 1. A well-dispersed methacrylated gelatin nanoparticle (MA-GNP) with an average size of ~100 nm is presented by a modified two-step desolvation method. 2. MA-GNP is readily introduced into the polyacrylamide (PAAm) system as a cross-linker to prepare macromolecular microsphere composites (MMC) hydrogels via a free radical polymerization reaction. 3. MA-GNP is an effective cross-linker, improving both the compressive resistance and elasticity of MMC hydrogels as well as the biocompatibility

Entropy and Its Quantum Thermodynamical Implication for Anomalous Spectral Systems

The state function entropy and its quantum thermodynamical implication for two typical dissipative systems with anomalous spectral densities are studied by investigating on their low-temperature quantum behavior. In all cases it is found that the entropy decays quickly and vanishes as the temperature approaches zero. This reveals a good conformity with the third law of thermodynamics and provides another evidence for the validity of fundamental thermodynamical laws in the quantum dissipative region.Comment: 10 pages, 3 figure

Spectroscopy of q3qˉ3\rm{q}^3\bar{\rm{q}}^3-States in Quark Model and Baryon-Antibaryon Enhancements

We study the mass spectrum of the $\rm{q}^3\bar{\rm{q}}^3$ mesons both from the quark model with triquark correlations and from common quark model with colormagnetic interactions and with relative S-waves between quarks. Two cluster configurations $(\rm{q}^3)-(\bar{\rm{q}}^3)$ and $(\rm{q}^2\bar{\rm{q}})-(\rm{q}\bar{\rm{q}}^2)$ are considered. In the spectrum we find rather stable states which have the same quantum number with particle resonances which are corresponding to the $p\bar{p}$ enhancement, $p\bar{\Lambda}$ enhancement and $\Lambda\bar{\Lambda}$ enhancement with spin-$\mathbf{0}$ or $\mathbf{1}$. This imply these enhancements are NOT experimental artifacts. The color-spin-flavor structures of $p\bar{p}$, $p\bar{\Lambda}$, and $\Lambda\bar{\Lambda}$ enhancements are revealed. The existence of spin-$\mathbf{1}$ $\Lambda\bar{\Lambda}, p\bar{\Lambda}, p\bar{p}$ enhancements is predicted.Comment: 45 pages, 5 figure

Variation of the Fine-Structure Constant from the de Sitter Invariant Special Relativity

There are obvious discrepancies among various experimental constraints on the variation of the fine-structure constant, $\alpha$. We attempt to discuss the issue in the framework of de Sitter invariant Special Relativity (${\cal SR}_{c,R}$) and to present a possible solution to the disagreement. In addition, on the basis of the observational data and the discussions presented in this Letter, we derive a rough theoretical estimate of the radius of the Universe.Comment: 8 pages, no figure

Satellite assessment of land surface evapotranspiration for the pan-Arctic domain

Regional evapotranspiration (ET), including water loss from plant transpiration and soil evaporation, is essential to understanding interactions between land-atmosphere surface energy and water balances. Vapor pressure deficit (VPD) and surface air temperature are key variables for stomatal conductance and ET estimation. We developed an algorithm to estimate ET using the Penman-Monteith approach driven by Moderate Resolution Imaging Spectroradiometer (MODIS)-derived vegetation data and daily surface meteorological inputs including incoming solar radiation, air temperature, and VPD. The model was applied using alternate daily meteorological inputs, including (1) site level weather station observations, (2) VPD and air temperature derived from the Advanced Microwave Scanning Radiometer (AMSR-E) on the EOS Aqua satellite, and (3) Global Modeling and Assimilation Office (GMAO) reanalysis meteorology-based surface air temperature, humidity, and solar radiation data. Model performance was assessed across a North American latitudinal transect of six eddy covariance flux towers representing northern temperate grassland, boreal forest, and tundra biomes. Model results derived from the three meteorology data sets agree well with observed tower fluxes (r \u3e 0.7; P \u3c 0.003; root mean square error of latent heat flux \u3c30 W m−2) and capture spatial patterns and seasonal variability in ET. The MODIS-AMSR-E–derived ET results also show similar accuracy to ET results derived from GMAO, while ET estimation error was generally more a function of algorithm parameterization than differences in meteorology drivers. Our results indicate significant potential for regional mapping and monitoring daily land surface ET using synergistic information from satellite optical IR and microwave remote sensing

Pressure-induced superconductivity and modification of Fermi surface in type-II Weyl semimetal NbIrTe₄

Weyl semimetals (WSMs) hosting Weyl points (WPs) with different chiralities attract great interest as an object to study chirality-related physical properties, topological phase transitions, and topological superconductivity. Quantum oscillation measurements and theoretical calculations imply that the type-II WPs in NbIrTe4 are robust against the shift of chemical potential making it a good material for pressure studies on topological properties. Here we report the results of electrical transport property measurements and Raman spectroscopy studies under pressures up to 65.5 GPa accompanied by theoretical electronic structure calculations. Hall resistivity data reveal an electronic transition indicated by a change of the charge carrier from multiband character to hole-type at similar to 12 GPa, in agreement with the calculated Fermi surface. An onset of superconducting transition is observed at pressures above 39 GPa, with critical temperature increasing as pressure increases. Moreover, theoretical calculations indicate that WPs persist up to highly reduced unit cell volume (-17%), manifesting that NbIrTe4 is a candidate of topological superconductor

Reducing Interanalyst Variability in Photovoltaic Degradation Rate Assessments

The economic return on investment of a commercial photovoltaic system depends greatly on its performance over the long term and, hence, its degradation rate. Many methods have been proposed for assessing system degradation rates from outdoor performance data. However, comparing reported values from one analyst and research group to another requires a common baseline of performance; consistency between methods and analysts can be a challenge. An interlaboratory study was conducted involving different volunteer analysts reporting on the same photovoltaic performance data using different methodologies. Initial variability of the reported degradation rates was so high that analysts could not come to a consensus whether a system degraded or not. More consistent values are received when written guidance is provided to each analyst. Further improvements in analyst variance was accomplished by using the free open-source software RdTools, allowing a reduction in variance between analysts by more than two orders of magnitude over the first round, where multiple analysis methods are allowed. This article highlights many pitfalls in conducting 'routine' degradation analysis, and it addresses some of the factors that must be considered when comparing degradation results reported by different analysts or methods

Pressure Effect on the superconducting properties of LaO_{1-x}F_{x}FeAs(x=0.11) superconductor

Diamagnetic susceptibility measurements under high hydrostatic pressure (up to 1.03 GPa) were carried out on the newly discovered Fe-based superconductor LaO_{1-x}F_{x}FeAs(x=0.11). The transition temperature T_c, defined as the point at the maximum slope of superconducting transition, was enhanced almost linearly by hydrostatic pressure, yielding a dT_c/dP of about 1.2 K/GPa. Differential diamagnetic susceptibility curves indicate that the underlying superconducting state is complicated. It is suggested that pressure plays an important role on pushing low T_c superconducting phase toward the main (optimal) superconducting phase.Comment: 7 pages, 4 figure