A model of HIV/AIDS population dynamics including ARV treatment and pre-exposure prophylaxis

Antiretroviral treatment (ART) and oral pre-exposure prophylaxis (PrEP) have recently been used efficiently in management of HIV infection. Pre-exposure prophylaxis consists in the use of an antiretroviral medication to prevent the acquisition of HIV infection by uninfected individuals. We propose a new model for the transmission of HIV/AIDS including ART and PrEP. Our model can be used to test the effects of ART and of the uptake of PrEP in a given population, as we demonstrate through simulations. The model can also be used to estimate future projections of HIV prevalence. We prove global stability of the disease-free equilibrium. We also prove global stability of the endemic equilibrium for the most general case of the model, i.e., which allows for PrEP individuals to default. We include insightful simulations based on recently published South-African data

Stochastic dynamics of an HIV/AIDS epidemic model with treatment

We investigate a stochastic HIV/AIDS epidemic model with treatment. The model allows for two stages of infection namely the asymptomatic phase and the symptomatic phase. We prove existence of global positive solutions. We show that the solutions are stochastically ultimately bounded and stochastically permanent. We also study asymptotic behaviour of the solution to the stochastic model around the disease-free equilibrium of the underlying deterministic model. Our theoretical results are illustrated by way of numerical simulations.Mathematics Subject Classification (2010): 92D30, 34K20.Keywords: Stochastic model, HIV/AIDS model, basic reproduction number, boundedness, permanenc