Modification of maladaptive memories during sleep and wakefulness: An interdisciplinary perspective

Las memorias consolidadas pueden atravesar por un período de labilidad frente a la presentación de recordatorios (claves ligadas al aprendizaje inicial), seguido de un proceso de re-estabilización conocido como reconsolidación. Por otro lado, el sueño tiene un rol activo en la formación y modificación de memorias, así como en la reducción del tono emocional de las experiencias. Durante el mismo, las nuevas memorias se reactivan, refuerzan e integran a las redes mnésicas preexistentes. Dentro del contexto terapéutico, se pueden evocar memorias antiguas según la necesidad del sujeto, lo que podría estar desencadenando constantes labilizaciones/reestabilizaciones, quizás sin ser conscientes de ello. En la presente revisión bibliográfica discutimos los avances neurocientíficos relacionados a la reactivación y modificación de memorias durante la vigilia y el sueño, así como los últimos desarrollos en terapias psicoterapéuticas para trastornos de ansiedad, con el objetivo de pensar una práctica más interdisciplinaria.As memórias consolidadas podem passar por um período de labilidade diante da apresentação de lembretes (chaves vinculadas ao aprendizado inicial), seguidos por um processo de reestabilização conhecido como reconsolidação. Por outro lado, o sono tem um papel ativo na formação e modificação de memórias, bem como na redução do tom emocional das experiências. Durante isso, as novas memórias são reativadas, reforçadas e integradas às redes de memória pré-existentes. No contexto terapêutico, velhas lembranças podem ser evocadas de acordo com a necessidade do sujeito, o que pode estar desencadeando constantes desestabilizações reestabilizações, talvez sem ter consciência disso. Nesta revisão bibliográfica, discutimos os avanços neurocientíficos relacionados à reativação e modificação de memórias durante a vigília e o sono, bem como os últimos desenvolvimentos em terapias psicoterapêuticas para transtornos de ansiedade, com o objetivo de pensar em uma prática mais interdisciplinar.Consolidated memories can return to a labile state after a reminder presentation (cue associated to the initial learning) followed by a re-stabilization process known as reconsolidation. Furthermore, sleep has an active role in the formation and modification of memories, as well as in decreasing the emotional tone of the experiences. During sleep, new memories are reactivated, reinforced and integrated into pre-existing networks. Within the therapeutic context, old memories can be retrieved according to the subject's needs, and this could be triggering repeated labilization/restabilization processes, perhaps without being aware of it. In this review we discuss the neuroscientific advances regarding memory reactivation and modification during sleep and wakefulness, as well as the latest approaches in psychotherapeutic therapies for anxiety disorders, with the aim of thinking about a more interdisciplinary practice.Fil: Bonilla, Matías. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto Tecnológico de Buenos Aires; ArgentinaFil: Jorge, Camila Isabel. Instituto Tecnológico de Buenos Aires; ArgentinaFil: Moyano, Malen Daiana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto Tecnológico de Buenos Aires; ArgentinaFil: Forcato, Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto Tecnológico de Buenos Aires; Argentin

Modification of maladaptive memories during sleep and wakefulness: an interdisciplinary perspective

Las memorias consolidadas pueden atravesar por un período de labilidad frente a la presentación de recordatorios (claves ligadas al aprendizaje inicial), seguido de un proceso de re-estabilización conocido como reconsolidación. Por otro lado, el sueño tiene un rol activo en la formación y modificación de memorias, así como en la reducción del tono emocional de las experiencias. Durante el mismo, las nuevas memorias se reactivan, refuerzan e integran a las redes mnésicas preexistentes. Dentro del contexto terapéutico, se pueden evocar memorias antiguas según la necesidad del sujeto, lo que podría estar desencadenando constantes labilizaciones/reestabilizaciones, quizás sin ser conscientes de ello. En la presente revisión bibliográfica discutimos los avances neurocientíficos relacionados a la reactivación y modificación de memorias durante la vigilia y el sueño, así como los últimos desarrollos en terapias psicoterapéuticas para trastornos de ansiedad, con el objetivo de pensar una práctica más interdisciplinaria.As memórias consolidadas podem passar por um período de labilidade diante da apresentação de lembretes (chaves vinculadas ao aprendizado inicial), seguidos por um processo de reestabilização conhecido como reconsolidação. Por outro lado, o sono tem um papel ativo na formação e modificação de memórias, bem como na redução do tom emocional das experiências. Durante isso, as novas memórias são reativadas, reforçadas e integradas às redes de memória pré-existentes. No contexto terapêutico, velhas lembranças podem ser evocadas de acordo com a necessidade do sujeito, o que pode estar desencadeando constantes desestabilizações reestabilizações, talvez sem ter consciência disso. Nesta revisão bibliográfica, discutimos os avanços neurocientíficos relacionados à reativação e modificação de memórias durante a vigília e o sono, bem como os últimos desenvolvimentos em terapias psicoterapêuticas para transtornos de ansiedade, com o objetivo de pensar em uma prática mais interdisciplinar.Consolidated memories can return to a labile state after a reminder presentation (cue associated to the initial learning) followed by a re-stabilization process known as reconsolidation. Furthermore, sleep has an active role in the formation and modification of memories, as well as in decreasing the emotional tone of the experiences. During sleep, new memories are reactivated, reinforced and integrated into pre-existing networks. Within the therapeutic context, old memories can be retrieved according to the subject's needs, and this could be triggering repeated labilization/restabilization processes, perhaps without being aware of it. In this review we discuss the neuroscientific advances regarding memory reactivation and modification during sleep and wakefulness, as well as the latest approaches in psychotherapeutic therapies for anxiety disorders, with the aim of thinking about a more interdisciplinary practice.Dossier: Memoria y emociónFacultad de Psicologí

One-week sleep hygiene education improves episodic memory in young but not in older adults during social isolation

Memory formation is a dynamic process that comprises different phases, such as encoding, consolidation and retrieval. It could be altered by several factors such as sleep quality, anxiety, and depression levels. In the last years, due to COVID-19 pandemic, there was a reduction in sleep quality, an increase in anxiety and depressive symptoms as well as an impairment in emotional episodic memory encoding, especially in young adults. Taking into account the profound impact of sleep quality in daily life a series of rules has been developed that are conducive to consistently achieving good sleep, known as sleep hygiene education. These interventions have been shown to be effective in improving sleep quality and duration and reducing depressive and anxiety symptoms. Here we propose the implementation of a brief sleep hygiene education to improve sleep quality and memory performance as well as to diminish anxiety and depressive scores. For that, participants were divided into two groups: Sleep hygiene education and control group. After that, they were evaluated for anxiety, depression, and sleep quality levels and trained on an episodic memory task. They were tested immediately after (short-term test) and also 1 week later (long-term test). This procedure was also performed before the sleep hygiene education and was taken as baseline level. We found that episodic memory performance for young adults improved for the SHE group after intervention but not for older adults, and no improvements in emotional variables were observed. Despite not observing a significant effect of the intervention for young and older adults regarding the sleep quality scores, we consider that there may be an improvement in sleep physiology that is not subjectively perceived, but would also have a positive impact on memory processes. These results show that even a sleep hygiene education of 1 week could improve cognition in young adults when acute memory and sleep impairment occurs, in this case, due to the isolation by COVID-19 pandemic. However, we suggest that longer interventions should be implemented for older adults who already experience a natural decline in cognitive processes such as episodic memory formation

Sleep hygiene impacts on episodic memories in young and older adults during quarantine by Covid-19: preliminary results

Sleep benefits off-line memory consolidation. Due to quarantine by Covid-19, sleep routines and sleep quality were affected. Preliminary results from our Lab showed that episodic memory formation is impaired by emotional variables, such as anxiety and depression. We hypothesize that sleep hygiene during quarantine positively impacts memory processes and emotional variables. To test this, we perform a 21-day study. Young and older participants were trained on the episodic memory task (video of neutral content). On day 7 they were tested and half of them began a sleep hygiene program. On day 14, participants were trained in a new episodic task and were tested on day 21. We found that young and older adults that received the sleep hygiene treatment had a positive impact on memory performance. Furthermore, older adults had better performance in memory recognition than young adults independently of the hygiene treatment. Moreover, older adults that received the sleep hygiene treatment showed a positive correlation between the total amount of sleep hygiene activities and the amount of correct recognition as well as a negative correlation with false recognition. We did not found a significant effect on emotional variables. These results demonstrate that sleep hygiene can be an effective tool for young and older adults to improve memory, however one-week treatment is not enough to induce emotional improvements.Fil: Tassone, Leonela Magali. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto Tecnológico de Buenos Aires; ArgentinaFil: Moyano, Malen Daiana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto Tecnológico de Buenos Aires; ArgentinaFil: Solferino, C.. Instituto Tecnológico de Buenos Aires; ArgentinaFil: Feldberg, Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto de Neurociencias Buenos Aires S. A.; ArgentinaFil: Tartaglini, Maria Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto de Neurociencias Buenos Aires S. A.; ArgentinaFil: Brusco, I.. Centro de Neuropsiquiatría y Neurología de la Conducta; ArgentinaFil: Forcato, Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto Tecnológico de Buenos Aires; ArgentinaXXXV Annual Meeting of the Argentinian Society for Neuroscience ResearchCiudad Autónoma de Buenos AiresArgentinaSociedad Argentina de Investigación en Neurociencia

Modificação de memórias desadaptativas durante o sono e a vigília: uma visão interdisciplinar

Consolidated memories can return to a labile state after a reminder presentation (cue associated to the initial learning) followed by a re-stabilization process known as reconsolidation. Furthermore, sleep has an active role in the formation and modification of memories, as well as in decreasing the emotional tone of the experiences. During sleep, new memories are reactivated, reinforced and integrated into pre-existing networks. Within the therapeutic context, old memories can be retrieved according to the subject's needs, and this could be triggering repeated labilization/re-stabilization processes, perhaps without being aware of it. . In this review we discuss the neuroscientific advances regarding memory reactivation and modification during sleep and wakefulness, as well as the latest approaches in psychotherapeutic therapies for anxiety disorders, with the aim of thinking about a more interdisciplinary practice.Las memorias consolidadas pueden atravesar por un período de labilidad frente a la presentación de recordatorios (claves ligadas al aprendizaje inicial), seguido de un proceso de re-estabilización conocido como reconsolidación. Por otro lado, el sueño tiene un rol activo en la formación y modificación de memorias, así como en la reducción del tono emocional de las experiencias. Durante el mismo, las nuevas memorias se reactivan, refuerzan e integran a las redes mnésicas preexistentes. Dentro del contexto terapéutico, se pueden evocar memorias antiguas según la necesidad del sujeto, lo que podría estar desencadenando constantes labilizaciones/reestabilizaciones, quizás sin ser conscientes de ello. En la presente revisión bibliográfica discutimos los avances neurocientíficos relacionados a la reactivación y modificación de memorias durante la vigilia y el sueño, así como los últimos desarrollos en terapias psicoterapéuticas para trastornos de ansiedad, con el objetivo de pensar una práctica más interdisciplinaria.As memórias consolidadas podem passar por um período de labilidade diante da apresentação de lembretes (chaves vinculadas ao aprendizado inicial), seguidos por um processo de reestabilização conhecido como reconsolidação. Por outro lado, o sono tem um papel ativo na formação e modificação de memórias, bem como na redução do tom emocional das experiências. Durante isso, as novas memórias são reativadas, reforçadas e integradas às redes de memória pré-existentes. No contexto terapêutico, velhas lembranças podem ser evocadas de acordo com a necessidade do sujeito, o que pode estar desencadeando constantes desestabilizações reestabilizações, talvez sem ter consciência disso.  Nesta revisão bibliográfica, discutimos os avanços neurocientíficos relacionados à reativação e modificação de memórias durante a vigília e o sono, bem como os últimos desenvolvimentos em terapias psicoterapêuticas para transtornos de ansiedade, com o objetivo de pensar em uma prática mais interdisciplinar

Sleep accelerates re-stabilization of human declarative memories

Consolidated memories can return to a labile state upon presentation of a reminder, followed by a period of re-stabilization known as reconsolidation. This period can take several hours, and if an amnesic agent (e.g. new learning) is administered inside the time window of reconsolidation (when the memory is still labile) the memory is impaired, whereas the memory remains unaffected if the amnesic agent is administered outside this time window. Sleep plays a fundamental role in the consolidation and integration of new memories, and recently sleep has also been implicated in memory reconsolidation. Here, we studied the role of sleep in accelerating the reconsolidation time window. On day 1, participants learned a list of syllable-pairs (List 1). On day 2, they received a reminder, followed by interference learning (List 2) administered either after 90 min of wakefulness, after 90 min of sleep, or after 10 h of wakefulness. On day 3, participants had to recall List 1 first, followed by List 2, and we assessed the Retrieval-Induced-Forgetting Effect (RIF) on List 2 as a measure of List 1 memory stability. We found that the 90 min sleep group showed an intact RIF effect similar to the 10 h wake group, reflecting stable List 1 memory after 90 min of sleep and after 10 h of wakefulness. However, the RIF effect was absent after 90 min of wakefulness, suggesting that the List 1 memory was still labile at that time. Moreover, the RIF effect in the 90 min sleep group was associated with power density in the slow oscillation frequency band (0.5–1 Hz) during SWS and S2. These findings suggest that 90 min of sleep accelerate memory re-stabilization after reminder presentation, shortening the reconsolidation time window and protecting the memory against subsequent interference. This rapid memory re-stabilization may depend on slow oscillation activity during NREM sleep.Fil: Moyano, Malen Daiana. Universidad Nacional Arturo Jauretche. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad en Red El Cruce Dr. Néstor Carlos Kirchner Samic. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos; Argentina. Gobierno de la Provincia de Buenos Aires. Hospital de Alta Complejidad Cuenca Alta Doctor Nestor Carlos Kirchner.; ArgentinaFil: Diekelmann, Susanne. Eberhard Karls Universität Tübingen.; AlemaniaFil: Pedreira, Maria Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; ArgentinaFil: Forcato, Cecilia. Universidad Nacional Arturo Jauretche. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad en Red El Cruce Dr. Néstor Carlos Kirchner Samic. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos; Argentina. Gobierno de la Provincia de Buenos Aires. Hospital de Alta Complejidad Cuenca Alta Doctor Nestor Carlos Kirchner.; Argentin

Non-linear susceptibility to interferences in declarative memory formation

After encoding, memories go through a labile state followed by a stabilizationprocess known as consolidation. Once consolidated they can enter a new labile stateafter the presentation of a reminder of the original memory, followed by a period of restabilization (reconsolidation). During these periods of lability the memory traces canbe modified. Currently, there are studies that show a rapid stabilization after 30 min,while others show that stabilization occurs after longer periods (e.g. 6 h). Here weinvestigate the effect of an interference treatment on declarative memoryconsolidation, comparing distinct time intervals after acquisition. On day 1, participantslearned a list of non- syllable pairs (List 1). Immediately after, 30 min, 3 h or 8 h later,they received an interference list (List 2) that acted as an amnesic agent. On day 2(48 h after training) participants had to recall List 1 first, followed by List 2. We foundthat the List 1 memory was susceptible to interference when the List 2 wasadministered immediately or 3 h after learning; however, shortly after acquisition (e.g.30 min) the List 1 memory becomes transiently protected against interference. Wepropose the possibility that this rapid memory protection could be induced by a fastand transient neocortical integration (where the memory is transiently protected)becoming partially independent from the hippocampus followed by a hippocampal reengagement where the memory becomes susceptible to interferences again. Ourresults open a discussion about the contribution of molecular and systemic aspects tomemory consolidation.Fil: Moyano, Malen Daiana. Instituto Tecnológico de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Carbonari, Giuliana. Instituto Tecnológico de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Bonilla, Matías. Instituto Tecnológico de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Pedreira, Maria Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; ArgentinaFil: Brusco, Luis Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires; ArgentinaFil: Kaczer, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; ArgentinaFil: Forcato, Cecilia. Instituto Tecnológico de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin