The Grizzly, November 8, 2001

Construction on Campus Continues as Scheduled • UC Leadership Scholars Attend Annual Halloween Concert • An Evening with Alice Parker a Musical Success • Peace Corps and City Year Representatives Speak About Careers in Common Good • Anthrax Vaccine at Center of Controversy • Opinions: Closed Courses and Wait Lists: Nightmares of Registration; Pop Goes the Quiz! • Gospel Choir Sings out for Peace, Prayer and Healing; Concert a Great Success • Judy Chicago is Coming! World-famous Artist to Visit Ursinus • Influenza Season is Upon Us • Comparative Prices on Museums • Self Protection Facts: What You Need to Know • Power of Dance • Rushing Season Begins Again • Gettysburg Becomes New CC Men\u27s Soccer Champion • UC Women\u27s Rugby Fighting the Good Fight • NCAA Volleyball Semi-finals • UC Downs FDUhttps://digitalcommons.ursinus.edu/grizzlynews/1500/thumbnail.jp

The Grizzly, November 29, 2001

UC Blueskies Calls for Help with Recycling • AIDS Legacy Continues in Poor Countries • Economics and Business Administration Panel Discussion Offers Students Advice on Finding Job Connections • Volunteers Wanted for NBA League Jam Session • UC Group Makes Plans for Alternative Spring Break • New California Law Enables Women to Obtain Emergency Contraceptive Pills without a Prescription • Opinions: So This is Christmas?; Family Bonding is Better than Trip to Spain; Letter of Apology • Messiah to Hit the Stage • Jazz Ensemble Keeps it Swinging • Comparative Pricing: Local Gasoline • Dougherty Finishes 123rd at Nationals • 8+6+9 = Success for UC Wrestling Team • Lady Bears Knocked off by Susquehanna • Duncan Selected as a Finalist for the Gagliardi Trophy • Captains Leading the Way to Victory for Bears Swimming • Bears Basketball Still Looking for First Winhttps://digitalcommons.ursinus.edu/grizzlynews/1502/thumbnail.jp

The Grizzly, November 15, 2001

Second Annual Operation Christmas Child a Success Thanks to the Holiday Spirit in UC Students • Ribbon Cutting Ceremony Held to Dedicate the New Floy Lewis Bakes Field House • With a New Face Comes Changes at Zack\u27s • SASA Sponsors Bizarre Turkey Contest • Ursinus Students Help in Election Campaign • Career Services Helps Misdirected Students • Great American Smokeout Turns Twenty-Five • Opinions: Thanksgiving not Really a Holiday at Ursinus; Zack\u27s: Think Twice About That Price; Take Three Advil: The Universal Cure from the Wellness Center • Cheesecake Factory far from a Cheesy Experience • The Glass Menagerie is Coming to Ursinus! • Open Mic Night Steals the Stage! • Olevian Hall: The First Women\u27s Dormitory at Ursinus • Advantages and Disadvantages of Working at the Mall this Holiday Season • Club Review • The Real Deal About Birth Control • UC Swimming Left to Choke on the Wake of Swarthmore • The New, Buffer, Women\u27s Basketball Team • Four Athletes Attempt to Save Passengers of Flight 93 • Ursinus Performs Exorcism on Devils • Going Deep with the Ursinus Scuba Diving Team • Dougherty Headed to Nationalshttps://digitalcommons.ursinus.edu/grizzlynews/1501/thumbnail.jp

The Grizzly, October 18, 2001

Sisters of Omega Chi Sponsor Blood Drive • Taking a Hike with the Environmental Studies Classes • World Cultures Club Encourages Campus-Wide Cultural Awareness • Gil Cook and Heather Potts Named 2001 Homecoming King and Queen • Understanding the Social Norms at Ursinus College • Ursinus Bookstore Holding Coat and Blanket Drive • Ursinus Alumna Martha Kriebel Reflects on the Unexpected Turns in Life\u27s Path • The Economic Effects of Terrorism • Struggling to Survive: The Way of Life for Women in Afghanistan • From Mexico to Collegeville: International Exchange Student Enrique Cobarrubias • Sophomore Week: Helping Students Reach Academic Goals • Second Annual Take Back the Night Rally & March Planned for Next Week • Opinions: Lady Wismer Attacks Students Saying Next Time, I\u27m Gonna Nail You! ; A Student\u27s Battle with Smoking; New Gym is Great, not Awkward; Message of Tolerance and Peace; One Resident Complains: Loss of Interest in Special Interest Houses • Dr. David Releases his own CD • New Road Brewhouse Ready to Rock! • Scary Way to Have a Fun Fall Day • Chinese Food: The Staple of Every College Student\u27s Diet • Can\u27t Decide What to do after Graduation? This Online Program Will Help • Class of 2003 has a new President • Ruby\u27s Restaurant: A Tasty Time Capsule • Give the Wismer Staff a Break: They\u27re Working for You • Who is Grizzly the Bear? • Ursinus Field Hockey Takes Victory over Holy Cross • Bears Wake from Hibernation; Crush Gettysburg 31-7 • Men\u27s Soccer Meets Gettysburg • Volleyball Wins Against Bryn Mawr and U. of the Sciences • XC Cleans up at Lehigh University • Barth Becomes Record-holder for Points • Field Hockey Changing NCAA Division • Women\u27s Soccer Rocks the Househttps://digitalcommons.ursinus.edu/grizzlynews/1497/thumbnail.jp

Investigation of hospital discharge cases and SARS-CoV-2 introduction into Lothian care homes

Background The first epidemic wave of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in Scotland resulted in high case numbers and mortality in care homes. In Lothian, over one-third of care homes reported an outbreak, while there was limited testing of hospital patients discharged to care homes. Aim To investigate patients discharged from hospitals as a source of SARS-CoV-2 introduction into care homes during the first epidemic wave. Methods A clinical review was performed for all patients discharges from hospitals to care homes from 1st March 2020 to 31st May 2020. Episodes were ruled out based on coronavirus disease 2019 (COVID-19) test history, clinical assessment at discharge, whole-genome sequencing (WGS) data and an infectious period of 14 days. Clinical samples were processed for WGS, and consensus genomes generated were used for analysis using Cluster Investigation and Virus Epidemiological Tool software. Patient timelines were obtained using electronic hospital records. Findings In total, 787 patients discharged from hospitals to care homes were identified. Of these, 776 (99%) were ruled out for subsequent introduction of SARS-CoV-2 into care homes. However, for 10 episodes, the results were inconclusive as there was low genomic diversity in consensus genomes or no sequencing data were available. Only one discharge episode had a genomic, time and location link to positive cases during hospital admission, leading to 10 positive cases in their care home. Conclusion The majority of patients discharged from hospitals were ruled out for introduction of SARS-CoV-2 into care homes, highlighting the importance of screening all new admissions when faced with a novel emerging virus and no available vaccine

SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway

Vaccines based on the spike protein of SARS-CoV-2 are a cornerstone of the public health response to COVID-19. The emergence of hypermutated, increasingly transmissible variants of concern (VOCs) threaten this strategy. Omicron (B.1.1.529), the fifth VOC to be described, harbours multiple amino acid mutations in spike, half of which lie within the receptor-binding domain. Here we demonstrate substantial evasion of neutralization by Omicron BA.1 and BA.2 variants in vitro using sera from individuals vaccinated with ChAdOx1, BNT162b2 and mRNA-1273. These data were mirrored by a substantial reduction in real-world vaccine effectiveness that was partially restored by booster vaccination. The Omicron variants BA.1 and BA.2 did not induce cell syncytia in vitro and favoured a TMPRSS2-independent endosomal entry pathway, these phenotypes mapping to distinct regions of the spike protein. Impaired cell fusion was determined by the receptor-binding domain, while endosomal entry mapped to the S2 domain. Such marked changes in antigenicity and replicative biology may underlie the rapid global spread and altered pathogenicity of the Omicron variant

Stress protein expression in primary and immortalized cultures of human thyroid cells: A model system for the study of stress proteins in the pathogenesis of autoimmune thyroid disease

Stress has, for many years, been linked to the onset of autoimmune disease and, in particular, autoimmune thyroid disease (AITD). Whilst the exact mechanism of this association is unknown, it is clear that episodes of stress can induce profound changes in the immune system. More specifically, recent studies from several laboratories have shown an association between the expression of stress proteins and, particularly, the Hsp70 family with AITD. Our own studies describe a thyroid-specific Hsp70 which shares antigenicity with the key thyroid autoantigen, thyroid peroxidase. Further studies on the molecular basis for this observation are, however, hampered by the lack of a suitably validated thyroid cell model. In this paper we compare the response of primary cultures of human thyrocytes to hyperthermia with the response seen in the immortalized human thyroid cell line HTori3. Both cell types responded in a broadly similar manner, synthesizing proteins from two of the major stress protein families, Hsp70 and Hsp90. In the primary human thyrocyte cultures the 70 kDa proteins showed a 7.5-fold increase and the 90 kDa proteins a 2.7-fold increase with hyperthermia whilst in the HTori3 cells the increases in response to hyperthermia were 10- and 6.5-fold, respectively. We also show a dose-dependent stress response in HTori3 cells cultured in the presence of arsenite ions. We conclude that the response of this highly differentiated and stable thyroid cell line to stress is similar to that seen in primary cultures of human thyroid cells and that these immortalized cells will afford a convenient and effective model for the further study of the role of stress in the pathology of AITD

The rise of vintage fashion and the vintage consumer

Amongst other factors, the current economic climate appears to have contributed to the trend of acquiring and reusing vintage clothing, accessories, and home-ware products, particularly with young consumers. The popularity of vintage has also been linked to a change in consumer attitudes towards wearing and utilizing second-hand goods. In addition to a change in attitudes, other factors that contribute to the growth of the vintage trend include a change in values, the inclusion of vintage inspirations used in current designs by fashion designers, and in the trends marketed by the forecasting sector, eco-sustainability, the media, and technology. Also vintage consumers and vintage retailers appear to share the viewpoint of the movement towards vintage fashion that has been assisted by a reaction against mass-produced fast fashion, as consumers strive for more individuality in their styling and garments. Eco-fashion and sustainable fashion ideals have emerged as solutions to the environmental issues that are currently inherent in the industry’s manufacturing processes, which have government and pressure group support. This ideal and practice complements the vintage trend phenomenon. This article explores the principal factors and the demographics of vintage consumers in the UK and their consumption habits to better understand the appeal and scope of this growing trend