Effects of benzo-α-pyren (BaP) on plasma levels of spermatogenesis related hormones (cortisol and testosterone) in functional male of yellowfin seabream, Acanthopagrus latus

The present study carried out to assess the effects of Benzo-α-Pyrene (BaP) as a serious member of Polycyclic Aromatic Hydrocarbons (PAH) on the plasma levels of cortisol and triiodothyronine (T3) hormones in male Seabream, Acanthopagrus latus (Sparidea). To assess the acute effects of BaP on the endocrine system, a group of fish was injected with dissolved BaP in sunflower oil (50mg/kg BaP in 2µg/l oil according to the body weight). Other fishes were injected with 2µg/l body weight as controls. Blood samples from both groups collected 3 hours after injection. In another protocol, the chronic effects of BaP on the plasma levels of cortisol and T3 were assessed. For this reason a group of fish was implanted with 50mg/kg BaP in 10µl/g coconut oil in respect to each fish body weight. As the previous protocol a control group was implanted with the same amount of oil without the BaP. Blood samples collected from both implanted groups (treatment and control) after 72 hours. According to the results, plasma levels of cortisol in yellowfin Seabream increased during both short time and long time exposure but T3 levels in the plasma decreased during the chronic stress of BaP exposure. It seems the cortisol levels are elevating to provide more energy requirement under the acute and chronic stress conditions by direct effect on glyconeogenesis and fast blood sugar level to be consumed by cells. T3 levels may be affected by inhibitory effect of Aryl hydrocarbon receptors (AhRs) which decreased it during long term exposure

The effect of naphthalene on endocrine disruptions in the stages of preheating and filtration of the fish of mead Liza klunzingeri

Without abstract

Assessment of flexed jacket platform using incremental wave analysis

Jacket-type offshore platforms play an important role in oil and gas industries in shallow and intermediate water depths such as Persian Gulf region. Such important structures need accurate considerations in analysis, design and assessment procedures. Incremental wave analysis for performance-based assessment of jacket platforms is established in 2011 to estimate different limit states and accurate behavior of jacket platform against environmental wave loading. IWA can be appropriate substitute to current pushover practice. The IWA can estimate the collapse-prevention limit state of jacket platforms properly. In addition, an appropriate parameter for ultimate capacity of offshore platforms is introduced which is called Collapse Wave Height (CWH). The CWH can be utilized as a substitute to RSR parameter in the design and assessment of jacket platforms. In this paper, IWA is explained. IWA curves, collapse-prevention limit state and CWH for case study platform is calculated. Effect of deck mass and its distribution on CWH is examined

Determination of lethal range and median lethal concentration (LC50 96h) values of diazinon on Caspian Sea common bream (Abramis brama)

Pesticides are environmental contaminants which normally enter to aquatic ecosystems after being used in aquaculture. In this research, acute toxicity of diazinon was studied on Caspian Sea common bream (Abramis brama). This pesticide may enter in aquatic food chain and cause serious problems for aquatic organisms as well as human. The acute toxicity test was performed during 96h in static renewal system based on the standard method proposed by OECD. A range finding test was carried out in aquariums containing 10L of test solution to determine the lethal range of diazinon on fish. The acute toxicity test was then preformed in 5 treatments and 3 triplicates for each treatment. Obtained data were analyzed using probit analysis with %5 confidence limit. According to the results, LC_50 24h, LC_50 48h, LC_50 72h and LC_50 96h of diazinon on Caspian Sea common bream was 10.974, 10.391, 9.134 and 7.316 respectively. The maximum acceptable toxicant concentration (MATC) of diazinon on Caspian Sea common bream was 0.073 mg/l and the lowest observed effect concentration which is equal to LC_50 96h was 2.63 mg/l. According to the results and comparing with other studies, it can be discussed that Caspian Sea common bream is more resistant against diazinon rather than other fish species. In addition, lethal toxicity of diazinon takes place in a moderate range of toxicant concentrations

GGPS1-associated muscular dystrophy with and without hearing loss

Ultra-rare biallelic pathogenic variants in geranylgeranyl diphosphate synthase 1 (GGPS1) have recently been associated with muscular dystrophy/hearing loss/ovarian insufficiency syndrome. Here, we describe 11 affected individuals from four unpublished families with ultra-rare missense variants in GGPS1 and provide follow-up details from a previously reported family. Our cohort replicated most of the previously described clinical features of GGPS1 deficiency; however, hearing loss was present in only 46% of the individuals. This report consolidates the disease-causing role of biallelic variants in GGPS1 and demonstrates that hearing loss and ovarian insufficiency might be a variable feature of the GGPS1-associated muscular dystrophy

Biallelic PRMT7 pathogenic variants are associated with a recognizable syndromic neurodevelopmental disorder with short stature, obesity, and craniofacial and digital abnormalities.

PURPOSE: Protein arginine methyltransferase 7 (PRMT7) is a member of a family of enzymes that catalyzes the methylation of arginine residues on several protein substrates. Biallelic pathogenic PRMT7 variants have previously been associated with a syndromic neurodevelopmental disorder characterized by short stature, brachydactyly, intellectual developmental disability, and seizures. To our knowledge, no comprehensive study describes the detailed clinical characteristics of this syndrome. Thus, we aim to delineate the phenotypic spectrum of PRMT7-related disorder. METHODS: We assembled a cohort of 51 affected individuals from 39 different families, gathering clinical information from 36 newly described affected individuals and reviewing data of 15 individuals from the literature. RESULTS: The main clinical characteristics of the PRMT7-related syndrome are short stature, mild to severe developmental delay/intellectual disability, hypotonia, brachydactyly, and distinct facial morphology, including bifrontal narrowing, prominent supraorbital ridges, sparse eyebrows, short nose with full/broad nasal tip, thin upper lip, full and everted lower lip, and a prominent or squared-off jaw. Additional variable findings include seizures, obesity, nonspecific magnetic resonance imaging abnormalities, eye abnormalities (i.e., strabismus or nystagmus), and hearing loss. CONCLUSION: This study further delineates and expands the molecular, phenotypic spectrum and natural history of PRMT7-related syndrome characterized by a neurodevelopmental disorder with skeletal, growth, and endocrine abnormalities