46 research outputs found

    Mycophenolate mofetil and intravenous cyclophosphamide are similar as induction therapy for class V lupus nephritis

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    Class V lupus nephritis (LN) occurs in one-fifth of biopsy-proven cases of systemic lupus erythematosus. To study the effectiveness of treatments in this group of patients, we pooled analysis of two large randomized controlled multicenter trials of patients with diverse ethnic and racial background who had pure class V disease. These patients received mycophenolate mofetil (MMF) or intravenous cyclophosphamide (IVC) as induction therapy for 24 weeks, with percentage change in proteinuria and serum creatinine as end points. Weighted mean differences, pooled odds ratios, and confidence intervals were calculated by using a random-effects model. A total of 84 patients with class V disease were divided into equal groups, each group had comparable entry variables but one received MMF and one received IVC. Within these groups, 33 patients on MMF and 32 patients on IVC completed 24 weeks of treatment. There were no differences between the groups in mean values for the measured end points. Similarly, no difference was found regarding the number of patients who did not complete the study or who died. In patients with nephrotic syndrome, no difference was noted between those treated with MMF and IVC regarding partial remission or change in urine protein. Hence we found that the response to MMF as induction treatment of patients with class V LN appears to be no different from that to IVC

    Research and innovation identified to decarbonise the maritime sector

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    The maritime sector requires technically, environmentally, socially, and economically informed pathways to decarbonise and eliminate all emissions harmful to the environment and health. This is extremely challenging and complex, and a wide range of technologies and solutions are currently being explored. However, it is important to assess the state-of-the-art and identify further research and innovation required to accelerate decarbonisation. The UK National Clean Maritime Research Hub have identified key priority areas to drive this process, with particular focus on marine fuels, power and propulsion, vessel efficiency, port operations and infrastructure, digitalisation, finance, regulation, and policy

    Observation of the post-construction performance of the system of groins along an eroding beach

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    A system of six groins was constructed along an eroding coast of reversing sediment transport. This paper describes the performance of the groin system in terms of the evolution of the shoreline, as function of angle of wave approach and the location of each groin within the system.Etude de cas consacrĂ©e Ă  la cĂŽte nord de la CrĂȘte oĂč la construction d’un port de pĂȘche a entraĂźnĂ© une vive Ă©rosion de la cĂŽte, avec pour consĂ©quence Ă©galement le rapide comblement du bassin. Un laboratoire a Ă©tudiĂ© diverses solutions possibles Ă  cette Ă©volution aprĂšs une modĂ©lisation complĂšte du systĂšme : celle-ci a permis de montrer l’existence d’une puissante dĂ©rive littorale, bien supĂ©rieure en volume Ă  ce qui s’échange entre La plage et les petits fonds. Les Ă©pis ont semblĂ© la meilleure des protections possibles dĂšs lors qu’on n’envisageait pas le dĂ©placement du port. L’implantation de 6 Ă©pis a fait l’objet d’un suivi dont les rĂ©sultats provisoires sont prĂ©sentĂ©s.Moutzouris Constantinos I. Observation of the post-construction performance of the system of groins along an eroding beach. In: Cahiers du Centre nantais de recherche pour l'amĂ©nagement rĂ©gional, n°41-42, 1994. DĂ©fense des cĂŽtes ou protection de l'espace littoral, quelles perspectives ? Actes du colloque international (17-20 octobre 1991) pp. 226-234

    Gas transfer under breaking waves: experiments and an improved vorticity-based model

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    In the present paper a modified vorticity-based model for gas transfer under breaking waves in the absence of significant wind forcing is presented. A theoretically valid and practically applicable mathematical expression is suggested for the assessment of the oxygen transfer coefficient in the area of wave-breaking. The proposed model is based on the theory of surface renewal that expresses the oxygen transfer coefficient as a function of both the wave vorticity and the Reynolds wave number for breaking waves. Experimental data were collected in wave flumes of various scales: a) small-scale experiments were carried out using both a sloping beach and a rubble-mound breakwater in the wave flume of the Laboratory of Harbor Works, NTUA, Greece; b) large-scale experiments were carried out with a sloping beach in the wind-wave flume of Delft Hydraulics, the Netherlands, and with a three-layer rubble mound breakwater in the Schneideberg Wave Flume of the Franzius Institute, University of Hannover, Germany. The experimental data acquired from both the small- and large-scale experiments were in good agreement with the proposed model. Although the apparent transfer coefficients from the large-scale experiments were lower than those determined from the small-scale experiments, the actual oxygen transfer coefficients, as calculated using a discretized form of the transport equation, are in the same order of magnitude for both the small- and large-scale experiments. The validity of the proposed model is compared to experimental results from other researchers. Although the results are encouraging, additional research is needed, to incorporate the influence of bubble mediated gas exchange, before these results are used for an environmental friendly design of harbor works, or for projects involving waste disposal at sea
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