The Star Cluster Population of M51: III. Cluster disruption and formation history

In this work we concentrate on the evolution of the cluster population of the interacting galaxy M51 (NGC 5194), namely the timescale of cluster disruption and possible variations in the cluster formation rate. We present a method to compare observed age vs. mass number density diagrams with predicted populations including various physical input parameters like the cluster initial mass function, cluster disruption, cluster formation rate and star bursts. If we assume that the cluster formation rate increases at the moments of the encounters with NGC 5195, we find an increase in the cluster formation rate of a factor of 3, combined with a disruption timescale which is slightly higher then when assuming a constant formation rate (t_4 = 200 Myr vs. 100 Myr). The measured cluster disruption time is a factor of 5 shorter than expected on theoretical grounds. This implies that the disk of M51 is not a preferred location for survival of young globular clusters, since even clusters with masses of the order of 10^6 M_sun will be destroyed within a few Gyr.Comment: 13 pages, A&A, accepte

Dimensionality of Carbon Nanomaterials Determines the Binding and Dynamics of Amyloidogenic Peptides: Multiscale Theoretical Simulations

Experimental studies have demonstrated that nanoparticles can affect the rate of protein self-assembly, possibly interfering with the development of protein misfolding diseases such as Alzheimer's, Parkinson's and prion disease caused by aggregation and fibril formation of amyloid-prone proteins. We employ classical molecular dynamics simulations and large-scale density functional theory calculations to investigate the effects of nanomaterials on the structure, dynamics and binding of an amyloidogenic peptide apoC-II(60-70). We show that the binding affinity of this peptide to carbonaceous nanomaterials such as C60, nanotubes and graphene decreases with increasing nanoparticle curvature. Strong binding is facilitated by the large contact area available for π-stacking between the aromatic residues of the peptide and the extended surfaces of graphene and the nanotube. The highly curved fullerene surface exhibits reduced efficiency for π-stacking but promotes increased peptide dynamics. We postulate that the increase in conformational dynamics of the amyloid peptide can be unfavorable for the formation of fibril competent structures. In contrast, extended fibril forming peptide conformations are promoted by the nanotube and graphene surfaces which can provide a template for fibril-growth

Impact of magnetic resonance-guided versus conventional radiotherapy workflows on organ at risk doses in stereotactic body radiotherapy for lymph node oligometastases

Background and purpose: Magnetic resonance (MR)-linac delivery is expected to improve organ at risk (OAR) sparing. In this study, OAR doses were compared for online adaptive MR-linac treatments and conventional cone beam computed tomography (CBCT)-linac radiotherapy, taking into account differences in clinical workflows, especially longer session times for MR-linac delivery. Materials and methods: For 25 patients with pelvic/abdominal lymph node oligometastases, OAR doses were calculated for clinical pre-treatment and daily optimized 1.5 T MR-linac treatment plans (5 × 7 Gy) and compared with simulated CBCT-linac plans for the pre-treatment and online anatomical situation. Bowelbag and duodenum were re-contoured on MR-imaging acquired before, during and after each treatment session. OAR hard constraint violations, D 0.5cc and D 10cc values were evaluated, focusing on bowelbag and duodenum. Results: Overall, hard constraints for all OAR were violated less often in daily online MR-linac treatment plans compared with CBCT-linac: in 5% versus 22% of fractions, respectively. D 0.5cc and D 10cc values did not differ significantly. When taking treatment duration and intrafraction motion into account, estimated delivered doses to bowelbag and duodenum were lower with CBCT-linac if identical planning target volume (PTV) margins were used for both modalities. When reduced PTV margins were achievable with MR-linac treatment, bowelbag doses were lower compared with CBCT-linac. Conclusions: Compared with CBCT-linac treatments, the online adaptive MR-linac approach resulted in fewer hard planning constraint violations compared with single-plan CBCT-linac delivery. With respect to other bowelbag/duodenum dose-volume parameters, the longer duration of MR-linac treatment sessions negatively impacts the potential dosimetric benefit of daily adaptive treatment planning

The Star Cluster Population of M51: III. Cluster disruption and formation history

In this work we concentrate on the evolution of the cluster population of the interacting galaxy M51 (NGC 5194), namely the timescale of cluster disruption and possible variations in the cluster formation rate. We present a method to compare observed age vs. mass number density diagrams with predicted populations including various physical input parameters like the cluster initial mass function, cluster disruption, cluster formation rate and star bursts. If we assume that the cluster formation rate increases at the moments of the encounters with NGC 5195, we find an increase in the cluster formation rate of a factor of 3, combined with a disruption timescale which is slightly higher then when assuming a constant formation rate (t_4 = 200 Myr vs. 100 Myr). The measured cluster disruption time is a factor of 5 shorter than expected on theoretical grounds. This implies that the disk of M51 is not a preferred location for survival of young globular clusters, since even clusters with masses of the order of 10^6 M_sun will be destroyed within a few Gyr

Fabrication of Functional Nanofibers Through Post-Nanoparticle Functionalization

A facile method is developed to functionalize nanofiber surfaces with nanoparticles (NPs) through dithiocarbamate chemistry. Gold nanoparticles (AuNPs) and quantum dots (QDs) are immobilized on the nanofiber surface. These surfaces provide scaffolds for further supramolecular functionalization, as demonstrated through the Forster resonance energy transfer (FRET) pairing of QD-decorated fibers and fluorescent proteins

Regulation of Macrophage Recognition through the Interplay of Nanoparticle Surface Functionality and Protein Corona

Using a family of cationic gold nanoparticles (NPs) with similar size and charge, we demonstrate that proper surface engineering can control the nature and identity of protein corona in physiological serum conditions. The protein coronas were highly dependent on the hydrophobicity and arrangement of chemical motifs on NP surface. The NPs were uptaken in macrophages in a corona-dependent manner, predominantly through recognition of specific complement proteins in the NP corona. Taken together, this study shows that surface functionality can be used to tune the protein corona formed on NP surface, dictating the interaction of NPs with macrophages