Profils épidémiologiques cliniques et bactériologiques des infections du tractus urinaire dans le service des maladies infectieuses et tropicales de l’hôpital Tenon de Paris: « étude préliminaire ».

Objectif : décrire les caractéristiques épidémiologiques, cliniques et bactériologiques des infections du tractus urinaire(ITU) dans le service des maladies infectieuses et tropicales du CHU de Ténon à Paris. Patients et méthodes : Il s’est agi d’une étude rétrospective réalisée le 25 Octobre 2016 dans le service des maladies infectieuses et tropicales du CHU de Ténon à Paris. Etaient inclus tous les patients hospitalisés, ayant à l’examen cytobactériologique des urines(ECBU) une leucocyturie significative et une uroculture positives. Résultats : Quatre patients avaient été recensés sur un total de 28 patients hospitalisés, soit une prévalence hospitalière de 14%. Leurs âges variaient entre 22 ans et 82 ans. Les signes urinaires étaient présents chez un seul patient, et étaient représentés par une dysurie et une douleur lombaire évoluant dans un contexte fébrile. Les bactéries isolées à l’examen cytobactériologique des urines(ECBU) étaient représentées par E. coli (2) dont 1 productrice de bétalactamase à spectre élargi(BLSE), P. aeruginosa(1), et K. pneumoniae (1) de phénotype sauvage tous les deux. Conclusion : Les ITU semblent relativement fréquentes au service des maladies infectieuses de l’hôpital Tenon. Ces infections évoluaient presque toujours avec d’autres comorbidités chez tous les patients. Elles s’accompagnaient rarement de signes d’appel urinaire d’où l’intérêt de leur recherche systématique dans le cadre de tout bilan infectieux

Cardiopulmonary assessment of patients with systemic sclerosis for hematopoietic stem cell transplantation: recommendations from the European Society for Blood and Marrow Transplantation Autoimmune Diseases Working Party and collaborating partners.

Systemic sclerosis (SSc) is a rare disabling autoimmune disease with a similar mortality to many cancers. Two randomized controlled trials of autologous hematopoietic stem cell transplantation (AHSCT) for SSc have shown significant improvement in organ function, quality of life and long-term survival compared to standard therapy. However, transplant-related mortality (TRM) ranged from 3-10% in patients undergoing HSCT. In SSc, the main cause of non-transplant and TRM is cardiac related. We therefore updated the previously published guidelines for cardiac evaluation, which should be performed in dedicated centers with expertize in HSCT for SSc. The current recommendations are based on pre-transplant cardiopulmonary evaluations combining pulmonary function tests, echocardiography, cardiac magnetic resonance imaging and invasive hemodynamic testing, initiated at Northwestern University (Chicago) and subsequently discussed and endorsed within the EBMT ADWP in 2016

Cardiopulmonary assessment of patients with systemic sclerosis for hematopoietic stem cell transplantation: recommendations from the European Society for Blood and Marrow Transplantation Autoimmune Diseases Working Party and collaborating partners.

Systemic sclerosis (SSc) is a rare disabling autoimmune disease with a similar mortality to many cancers. Two randomized controlled trials of autologous hematopoietic stem cell transplantation (AHSCT) for SSc have shown significant improvement in organ function, quality of life and long-term survival compared to standard therapy. However, transplant-related mortality (TRM) ranged from 3-10% in patients undergoing HSCT. In SSc, the main cause of non-transplant and TRM is cardiac related. We therefore updated the previously published guidelines for cardiac evaluation, which should be performed in dedicated centers with expertize in HSCT for SSc. The current recommendations are based on pre-transplant cardiopulmonary evaluations combining pulmonary function tests, echocardiography, cardiac magnetic resonance imaging and invasive hemodynamic testing, initiated at Northwestern University (Chicago) and subsequently discussed and endorsed within the EBMT ADWP in 2016

Numerical modeling of arterial pulse wave propagation to characterize aortic hemodynamic: Validation using magnetic resonance data

International audienc

Descending aorta subject-specific one-dimensional model validated against in vivo data

The aorta plays a major role in the cardiovascular system and its function and structure are primarily affected by aging, eating habits, life style and other cardiovascular risk factors, inducing increased stiffness which is associated with cardiovascular and cerebral morbi-mortality. Our objective was to develop and validate a robust subject-specific one-dimensional wave propagation numerical model of the descending aorta. This model with a cross-sectional area, velocity and pressure formulation is built using geometric and hemodynamic data measured on a specific person and is validated against in vivo data acquired on the same subject at three distinct anatomical locations along the thoracic aorta. We studied seven healthy volunteers, who underwent carotid applanation tonometry and aortic cardiovascular magnetic resonance (CMR). Responses of our model in terms of changes in central pressure waveform with arterial alterations were consistent with previously described physiological knowledge. Quantitative validation averaged over the three descending aortic locations and the seven subjects provided low rms errors (given in percentage of the maximal clinical value) between simulated and CMR data, i.e. area: 10±6%, velocity: 11±3%, flow rate: 9±3%. Finally, we also found low rms (5±2%) when comparing simulated pressure in the proximal aortic location against tonometric carotid pressure curves. In conclusion, this simple model performs similar to more complex models of the entire systemic arterial tree at a fraction of the cost, and could be of major usefulness in the non-invasive and local estimation of proximal biomechanical and hemodynamic indices. © 2013 Elsevier Ltd

How to estimate aortic characteristic impedance from magnetic resonance and applanation tonometry data?

International audienc

Synthesis and Biological Evaluations of Ghrelin Ligands

International audienc

Ghrelin ligands : from design and synthesis to clinical studies

National audienc

Ghrelin ligands : from design and synthesis to clinical studies

National audienc