Electromagnetic Radiation Measurements and Safety Issues of some Cellular

As the mobile telecommunication systems are tremendously growing allover the world then the numbers of handheld andbase stations are also rapidly growing and it became very popular to see these base stations distributed everywhere in theneighborhood and on roof tops which has caused a considerable amount of panic to the public in Palestine concerning witherthe radiated electromagnetic field from these base stations may cause any health effect or hazard. This paper focuses on theradiated electromagnetic energy from some typical mobile base stations around the city of Nablus. The exposure levels dueto these stations were measured and compared to some international standard guidelines like ICNIRP and FCC to see if itmeets these standards, this is in order to answer some of the public fear and concern. The results are presented and somecomments are made on the other sources of electromagnetic radiation in the 200 kHz to 3 GHz range

Pharmacogenomics in cardiovascular disorders: Steps in approaching personalized medicine in cardiovascular medicine

Christopher Barone, Shaymaa S Mousa, Shaker A MousaThe Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Albany, NY, USAAbstract: Some of the most commonly prescribed medications are those for cardiovascular maladies. The beneficial effects of these medications have been well documented. However, there can be substantial variation in response to these medications among patients, which may be due to genetic variation. For this reason pharmacogenomic studies are emerging across all aspects of cardiovascular medicine. The goal of pharmacogenomics is to tailor treatment to an individual’s genetic makeup in order to improve the benefit-to-risk ratio. This review examines the potential pharmacogenomic parameters which may lead to a future of personalized medicine. For example, it has been found that patients with CYP2C9 and VKORC1 gene variations have a different response to warfarin. Other studies looking at β-blockers, ACE inhibitors, ARBs, diuretics and statins have shown some results linking genetic variations to pharmacologic response. However these studies have not impacted clinical use yet, unlike warfarin findings, as the small retrospective studies need to be followed up by larger prospective studies for definitive results.Keywords: cardiovascular, pharmacogenomics, genetics, cardiovascular medicine, personalized medicine, polymorphis

Polycystic ovary syndrome and its impact on women’s quality of life: More than just an endocrine disorder

In the past, polycystic ovary syndrome has been looked at primarily as an endocrine disorder. Studies now show that polycystic ovary syndrome is a metabolic, hormonal, and psychosocial disorder that impacts a patient’s quality of life. It is extremely important to holistically treat these patients early on to help them deal with the emotional stress that is often overlooked with polycystic ovary syndrome. Early diagnosis and long term management can help control polycystic ovary syndrome so that women can still live a healthy active life and avoid long-term complications such as metabolic syndrome and cardiovascular diseases

Current status and future directions in the management of chronic hepatitis C

Hepatitis C virus (HCV) is endemic worldwide, and it causes cirrhosis and other complications that often lead to death; nevertheless, our knowledge of the disease and its mechanisms is limited. HCV is most common in underdeveloped nations, including many in Africa and Asia. The virus is usually transmitted by parenteral routes, but sexual, perinatal, and other types of transfer have been known to occur. Approximately 80% of individuals who contract hepatitis C develop a chronic infection, and very few are able to spontaneously clear the virus. Because hepatitis C is asymptomatic in the majority of patients, the presence of HCV RNA in the serum is the best diagnostic tool. Although serious complications from hepatitis C may not occur for 20 years, 1/5 of chronic patients eventually develop life - threatening cirrhosis. More research is needed on the different therapy options for the disease, and many factors, most importantly the genotype of the virus, must be taken into account before beginning any treatment. As there is no vaccine against HCV at present, the most effective and recommended therapy is pegylated-interferon-α-2a plus ribavirin. While interferon is marginally effective as a monotherapy, both adding the moiety and combining it with ribavirin have been shown to dramatically increase its potency. While there are numerous alternative and complementary medicines available for patients with hepatitis C, their efficacy is questionable. Currently, research is being done to investigate other possible treatments for hepatitis C, and progress is being made to develop a vaccine against HCV, despite the many challenges the virus presents. Until such a vaccination is available, prevention and control methods are important in containing and impeding the spread of the virus and mitigating its deleterious effects on the health of people and communities worldwide

THE POTENTIAL MODULATORY EFFECT OF RUTIN ON TITANIUM DIOXIDE NANOPARTICLES-INDUCED RENAL INJURY IN MALE MICE

Objective: This study aimed to investigate the possible protective effect of rutin in management of TiO2NPs-induced renal injury in mice. Methods: Forty male Swiss albino mice were randomly divided into four groups (n=10). Group (I) served as a control group, group (II) received 100 mg/kg body weight (b. wt) of rutin (orally), group (III) received 70 mg/kg b. wt of TiO2NPs,injected intraperitoneally (i. p.), Group (IV) received 70 mg/kg b. wt of TiO2NPs plus 100 mg/kg b. wt of rutin; for 14 successive days. The renal toxicity was determined through evaluating the renal function biomarkers (serum creatinine, urea, and uric acid) and the levels of malondialdehyde (MDA), reduced glutathion (GSH), nuclear factor kappa B (NF-kB), tumor necrosis factor-α (TNF)-α, B-cell lymphoma (BCL)-2 and caspase-3 in renal tissues. Results: Administration of TiO2NPs plus rutin prevented the deleterious effect of TiO2NPs on mice kidneys through improving the renal functions, and alleviating the increase in MDA, NF-kB, TNF-α, and caspase-3 levels, as well as the decrease in GSH andBCL-2 levels, in renal tissues. Conclusion: Taken together, these findings suggested that rutin plays a role in alleviating TiO2NPs-induced oxidative stress, inflammation, and apoptosis, and exerts renal protective effects

A REVIEW OF THE HISTORY OF THE CORONAVIRUS DISEASE 2019

The coronavirus (CoV) family has many more pathological causes for humans and animals. CoV disease 2019 (COVID-19) has spread very rapidly worldwide is endemic, was first identified, isolated from pneumonia, and sourced to Wuhan is located in central China in 2019. The last reports have proposed that severe acute respiratory syndrome-associated CoV (SARS-CoV) deems altered CoV from bat source that came to many people as a due of zoonosis relocation. CoV was treated as a simple non-fatal virus until 2002, then started showing deaths SARS-CoV-1 from 2003 at a rate of 9.6%, in 2004, the Centers for Disease Control and the World Health Organization (WHO) declared of emergency. Middle East respiratory syndrome CoV has been discovered in dromedaries and has continued to kill humans since 2012, and the WHO was confirmed by the Chinese government of several cases of pneumonia by the end of 2019 and these cases were related to the Seafood Market in Huanan, 2020, was the COVID-19 pandemic, this virus was able to spread rapidly among people in most countries of the world, which made the proportion of mortality is rising very alarmingly. Therefore, all states must be careful and take precautionary measures to avoid infection. In this article, we review the origin of CoVs, their global transmission map, and their path of entry into humans

I hear you eat and speak: automatic recognition of eating condition and food type, use-cases, and impact on ASR performance

We propose a new recognition task in the area of computational paralinguistics: automatic recognition of eating conditions in speech, i. e., whether people are eating while speaking, and what they are eating. To this end, we introduce the audio-visual iHEARu-EAT database featuring 1.6 k utterances of 30 subjects (mean age: 26.1 years, standard deviation: 2.66 years, gender balanced, German speakers), six types of food (Apple, Nectarine, Banana, Haribo Smurfs, Biscuit, and Crisps), and read as well as spontaneous speech, which is made publicly available for research purposes. We start with demonstrating that for automatic speech recognition (ASR), it pays off to know whether speakers are eating or not. We also propose automatic classification both by brute-forcing of low-level acoustic features as well as higher-level features related to intelligibility, obtained from an Automatic Speech Recogniser. Prediction of the eating condition was performed with a Support Vector Machine (SVM) classifier employed in a leave-one-speaker-out evaluation framework. Results show that the binary prediction of eating condition (i. e., eating or not eating) can be easily solved independently of the speaking condition; the obtained average recalls are all above 90%. Low-level acoustic features provide the best performance on spontaneous speech, which reaches up to 62.3% average recall for multi-way classification of the eating condition, i. e., discriminating the six types of food, as well as not eating. The early fusion of features related to intelligibility with the brute-forced acoustic feature set improves the performance on read speech, reaching a 66.4% average recall for the multi-way classification task. Analysing features and classifier errors leads to a suitable ordinal scale for eating conditions, on which automatic regression can be performed with up to 56.2% determination coefficient

Opioid therapy and tumor progression

It is well established that opioids help the organism to cope with environmental stress, tissue injury, pathogen invasion, inflammation, and tumor growth. Opioids elicit immunosupressive effects which may become benefitial in the context of chronic inflammation, however, it may be detremental in the context of tissue repair. These direct immunosuppressive effects of opioids would possibly facilitate tumor growth, however, in the context of pain and distress, which is known to promote tumor progression by a reduction in NK cell cytotoxicity, opioids clearly show a beneficial effect in reducing local tumor growth as well as dissemination of metastases. Recently, growing evidence accumulates that tumor cells express both opioid receptors and their ligands, the opioid peptides, suggesting that opioids may also directly affect tumor progression. Metenkephalin seems to play a most prominent role possibly acting via a different receptor than the classical opioid receptor. However, there is still great need for further studies to corroborate these interesting findings.It is well established that opioids help the organism to cope with environmental stress, tissue injury, pathogen invasion, inflammation, and tumor growth. Opioids elicit immunosupressive effects which may become benefitial in the context of chronic inflammation, however, it may be detremental in the context of tissue repair. These direct immunosuppressive effects of opioids would possibly facilitate tumor growth, however, in the context of pain and distress, which is known to promote tumor progression by a reduction in NK cell cytotoxicity, opioids clearly show a beneficial effect in reducing local tumor growth as well as dissemination of metastases. Recently, growing evidence accumulates that tumor cells express both opioid receptors and their ligands, the opioid peptides, suggesting that opioids may also directly affect tumor progression. Metenkephalin seems to play a most prominent role possibly acting via a different receptor than the classical opioid receptor. However, there is still great need for further studies to corroborate these interesting findings

Therapeutics formulated to target cancer stem cells: Is it in our future?

With the political, social and financial drives for cancer research, many advances have been made in the treatment of many different cancer types. For example, given the increase in awareness, early detection, and treatment of breast and prostate cancers, we have seen substantial increases in survival rates. Unfortunately there are some realms of cancer that have not seen these substantial advancements, largely due to their rapid progression and the inability to specifically target therapy