MME-T-MEDNet: Mass mortality events in Mediterranean marine coastal ecosystems

The Mass Mortality Events database (hereafter MME-T-MEDNet) is a collaborative initiative involving more than 30 research institutions from 10 Mediterranean countries including EU and non-EU countries. This initiative aims to facilitate the access to information (published in scientific journals and gray literature or still unpublished) related to Mediterranean Mass Mortality Events (MMEs)

MME-T-MEDNet: Mass mortality events in Mediterranean marine coastal ecosystems [Dataset]

The data compiled in the MME-T-MEDNet dataset was gathered from published scientific papers, grey literature and technical reports using different searching strategies in ISI Web of Knowledge and Google Scholar using different sets of keywords (including those used in Rivetti et al. 2014 and Marba et al. 2015) as well as through contacts with researchers across the Mediterranean. The dataset comprises mass mortality events impacts observed at discrete events generally related to warming episodes across the Mediterranean. The dataset provides information about the year, season, geographic coordinates, protection status of the geographic location, species phylum, species name, the degree of mortality impact, depth range of the mortality and reported biotic and abiotic mortality drivers of the event.The MME-T-MEDNet database is subject to a Creative Commons Attribution-Noncommercial-ShareAlike International licence 4.0.Contact person for enquiries: [email protected] update..The Mass Mortality Events (MME-T-MEDNet) dataset compiles information reported on mass mortality events of species in the Mediterranean Sea affecting different organism dwelling in coastal ecosystems.We acknowledge the financial support by the Prince Albert II de Monaco Foundation (MIMOSA project nº 1983) and the project MPA-ADAPT funded by Interreg MED program (European Regional Development Fund)Sólo un dataset.Peer reviewe

The tale of TILs in breast cancer: A report from The International Immuno-Oncology Biomarker Working Group

The advent of immune-checkpoint inhibitors (ICI) in modern oncology has significantly improved survival in several cancer settings. A subgroup of women with breast cancer (BC) has immunogenic infiltration of lymphocytes with expression of programmed death-ligand 1 (PD-L1). These patients may potentially benefit from ICI targeting the programmed death 1 (PD-1)/PD-L1 signaling axis. The use of tumor-infiltrating lymphocytes (TILs) as predictive and prognostic biomarkers has been under intense examination. Emerging data suggest that TILs are associated with response to both cytotoxic treatments and immunotherapy, particularly for patients with triple-negative BC. In this review from The International Immuno-Oncology Biomarker Working Group, we discuss (a) the biological understanding of TILs, (b) their analytical and clinical validity and efforts toward the clinical utility in BC, and (c) the current status of PD-L1 and TIL testing across different continents, including experiences from low-to-middle-income countries, incorporating also the view of a patient advocate. This information will help set the stage for future approaches to optimize the understanding and clinical utilization of TIL analysis in patients with BC