770 research outputs found
Improved Blast Capacity of Pre-engineered Metal Buildings using Coupled CFD and FEA Modeling
PresentationThe initial CCPS guideline [CCPS, 1996] for estimating lethality for building occupants within petrochemical buildings subjected to blast hazards was based on building construction type and peak overpressure. This method allows for a quick screening of building occupant vulnerability but does not include the effects of the duration of the blast that the buildings are subjected to. Blast hazards within petrochemical facilities include vapor cloud explosions (VCE), BLEVEs, and bursting pressure vessels. VCE’s include both deflagrations having long blast durations and detonations having much shorter durations. Bursting pressure vessels can also be characterized as having relatively short durations. Therefore, the latest CCPS guideline [CCPS, 2012] removed this singular peak overpressure methodology and provided occupant vulnerability as a function of building damage and construction type as a function of peak overpressure and duration. Unfortunately, this improved method on blast characterization did not provide a way to correlate blast loading with building damage. This blast-to-damage correlation is required to conduct quantitative risk assessments. A range of simplified tools are available for assessing the response of structural components and building construction types to blast loads. These tools include Single Degree of Freedom (SDOF) models and Pressure-Impulse (P-I) iso-damage charts. These simplified tools generally do not account for the complex response and failure of real structures or the difference in response to different forms of blast loading that include finite rise times (blast waves). Iso-damage charts may be based upon historical data gathered from a range of sources and are often based upon blast damage caused by High Explosive (HE) detonations. This presentation illustrates the use of multi-degree of freedom structural systems for a pre- engineered metal building (PEMB). PEMBs represent the majority of building construction within petrochemical facilities. Computational Structural Dynamic (CSD) finite element analysis (FEA) and Computational Fluid Dynamic (CFD) approaches are used to show the level of conservatism in estimating the blast capacity of PEMBs compared to more traditional SDOF methods. Fully coupled CFD and FEA modeling that includes the beneficial effect of including the air that is internal to the building is demonstrated
PCV8 Differences in the Weighted Average Daily Doses of Statins in Latin America and Their Potential Impact on Cardiovascular Outcomes
Up-down instability of binary black holes in numerical relativity
Binary black holes with spins that are aligned with the orbital angular momentum do not precess. However, post-Newtonian calculations predict that "up-down" binaries, in which the spin of the heavier (lighter) black hole is aligned (antialigned) with the orbital angular momentum, are unstable when the spins are slightly perturbed from perfect alignment. This instability provides a possible mechanism for the formation of precessing binaries in environments where sources are preferentially formed with (anti) aligned spins. In this paper, we present the first full numerical relativity simulations capturing this instability. These simulations span orbits and - precession cycles before merger, making them some of the longest numerical relativity simulations to date. Initialized with a small perturbation of -, the instability causes a dramatic growth of the spin misalignments, which can reach near merger. We show that this leaves a strong imprint on the subdominant modes of the gravitational wave signal, which can potentially be used to distinguish up-down binaries from other sources. Finally, we show that post-Newtonian and effective-one-body approximants are able to reproduce the unstable dynamics of up-down binaries extracted from numerical relativity
Molecular definition of a narrow interval at 7q22.1 associated with myelodysplasia
Chromosome 7 translocations, deletions, or monosomy are associated with myelodysplasia (MDS) and acute myeloid leukemia both in children and adults. These chromosomal anomalies represent one of the most common cytogenetic abnormalities associated with these diseases and usually herald a poor prognosis. In this study two cosmid DNA probes that mapped to 7q22.1 and were known to be separated by approximately 500 kb were identified to flank the proximal inversion breakpoint in a patient carrying a constitutional inversion (7q22.1-34) associated with MDS. A yeast artificial chromosome (YAC) clone that encompassed the two cosmids was identified and shown to span the breakpoint. Fluorescence in situ hybridization was then used to analyze six additional patients with myelodysplasia and chromosomal rearrangements of the 7q22 region (three patients had translocations and three carried deletions). The breakpoint in one of the patients was found to be contained within the same YAC clone that spanned the inversion breakpoint. Moreover, this same interval was determined to be absent in all three patients with chromosomal deletions. These results suggest that this segment of DNA on chromosome 7q22.1 may contain specific gene(s) that have a significant role in myeloid malignancies.link_to_OA_fulltex
The protein import apparatus of chloroplasts
Routing of cytosolically synthesized precursor proteins into chloroplasts is a specific process which involves a multitude of soluble and membrane components. In this review we wil1 focus on early events of the translocation pathway of nuclear coded plastidic precursor proteins and compare import routes for polypeptide of the outer chloroplast envelope to that of internal chloroplast compartments. A number of proteins housed in the chloroplast envelopes have been implied to be involved in the translocation process, but so far a certain function has not been assigned to any of these proteins. The only exception could be an envelope localized hsc 70 homologue which could retain the import competence of a precursor protein in transit into the organelle
Ray Tracing Simulations of Weak Lensing by Large-Scale Structure
We investigate weak lensing by large-scale structure using ray tracing
through N-body simulations. Photon trajectories are followed through high
resolution simulations of structure formation to make simulated maps of shear
and convergence on the sky. Tests with varying numerical parameters are used to
calibrate the accuracy of computed lensing statistics on angular scales from
about 1 arcminute to a few degrees. Various aspects of the weak lensing
approximation are also tested. For fields a few degrees on a side the shear
power spectrum is almost entirely in the nonlinear regime and agrees well with
nonlinear analytical predictions. Sampling fluctuations in power spectrum
estimates are investigated by comparing several ray tracing realizations of a
given model. For survey areas smaller than a degree on a side the main source
of scatter is nonlinear coupling to modes larger than the survey. We develop a
method which uses this effect to estimate the mass density parameter Omega from
the scatter in power spectrum estimates for subregions of a larger survey. We
show that the power spectrum can be measured accurately from realistically
noisy data on scales corresponding to 1-10 Mpc/h. Non-Gaussian features in the
one point distribution function of the weak lensing convergence (reconstructed
from the shear) are also sensitive to Omega. We suggest several techniques for
estimating Omega in the presence of noise and compare their statistical power,
robustness and simplicity. With realistic noise Omega can be determined to
within 0.1-0.2 from a deep survey of several square degrees.Comment: 59 pages, 22 figures included. Matches version accepted for Ap
A Database of Cepheid Distance Moduli and TRGB, GCLF, PNLF and SBF Data Useful for Distance Determinations
We present a compilation of Cepheid distance moduli and data for four
secondary distance indicators that employ stars in the old stellar populations:
the planetary nebula luminosity function (PNLF), the globular cluster
luminosity function (GCLF), the tip of the red giant branch (TRGB), and the
surface brightness fluctuation (SBF) method. The database includes all data
published as of July 15, 1999. The main strength of this compilation resides in
all data being on a consistent and homogeneous system: all Cepheid distances
are derived using the same calibration of the period-luminosity relation, the
treatment of errors is consistent for all indicators, measurements which are
not considered reliable are excluded. As such, the database is ideal for
inter-comparing any of the distance indicators considered, or for deriving a
Cepheid calibration to any secondary distance indicator. Specifically, the
database includes: 1) Cepheid distances, extinctions and metallicities; 2)
apparent magnitudes of the PNLF cutoff; 3) apparent magnitudes and colors of
the turnover of the GCLF (both in the V- and B-bands); 4) apparent magnitudes
of the TRGB (in the I-band) and V-I colors at and 0.5 magnitudes fainter than
the TRGB; 5) apparent surface brightness fluctuation magnitudes I, K', K_short,
and using the F814W filter with the HST/WFPC2. In addition, for every galaxy in
the database we give reddening estimates from DIRBE/IRAS as well as HI maps,
J2000 coordinates, Hubble and T-type morphological classification, apparent
total magnitude in B, and systemic velocity. (Abridged)Comment: Accepted for publication in the Astrophysical Journal Supplement
Series. Because of space limitations, the figures included are low resolution
bitmap images. Original figures can be found at
http://www.astro.ucla.edu/~laura/pub.ht
The Extragalactic Distance Scale Key Project XXVII. A Derivation of the Hubble Constant Using the Fundamental Plane and Dn-Sigma Relations in Leo I, Virgo, and Fornax
Using published photometry and spectroscopy, we construct the fundamental
plane and D_n-Sigma relations in Leo I, Virgo and Fornax. The published Cepheid
P-L relations to spirals in these clusters fixes the relation between angular
size and metric distance for both the fundamental plane and D_n-Sigma
relations. Using the locally calibrated fundamental plane, we infer distances
to a sample of clusters with a mean redshift of cz \approx 6000 \kms, and
derive a value of H_0=78+- 5+- 9 km/s/Mpc (random, systematic) for the local
expansion rate. This value includes a correction for depth effects in the
Cepheid distances to the nearby clusters, which decreased the deduced value of
the expansion rate by 5% +- 5%. If one further adopts the metallicity
correction to the Cepheid PL relation, as derived by the Key Project, the value
of the Hubble constant would decrease by a further 6%+- 4%. These two sources
of systematic error, when combined with a +- 6% error due to the uncertainty in
the distance to the Large Magellanic Cloud, a +- 4% error due to uncertainties
in the WFPC2 calibration, and several small sources of uncertainty in the
fundamental plane analysis, combine to yield a total systematic uncertainty of
+- 11%. We find that the values obtained using either the CMB, or a flow-field
model, for the reference frame of the distant clusters, agree to within 1%. The
Dn-Sigma relation also produces similar results, as expected from the
correlated nature of the two scaling relations. A complete discussion of the
sources of random and systematic error in this determination of the Hubble
constant is also given, in order to facilitate comparison with the other
secondary indicators being used by the Key Project.Comment: 21 pages, 3 figures, Accepted for publication in Ap
The disruption of nearby galaxies by the Milky Way
Interactions between galaxies are common and are an important factor in
determining their physical properties such as position along the Hubble
sequence and star-formation rate. There are many possible galaxy interaction
mechanisms, including merging, ram-pressure stripping, gas compression,
gravitational interaction and cluster tides. The relative importance of these
mechanisms is often not clear, as their strength depends on poorly known
parameters such as the density, extent and nature of the massive dark halos
that surround galaxies. A nearby example of a galaxy interaction where the
mechanism is controversial is that between our own Galaxy and two of its
neighbours -- the Large and Small Magellanic Clouds. Here we present the first
results of a new HI survey which provides a spectacular view of this
interaction. In addition to the previously known Magellanic Stream, which
trails 100 degrees behind the Clouds, the new data reveal a counter-stream
which lies in the opposite direction and leads the motion of the Clouds. This
result supports the gravitational model in which leading and trailing streams
are tidally torn from the body of the Magellanic Clouds.Comment: 17 pages with 5 figures in gif format, scheduled for publication in
the August 20th, 1998 issue of Natur
HIPASS Detection of an Intergalactic Gas Cloud in the NGC 2442 Group
We report the discovery, from the HI Parkes All-Sky Survey (HIPASS), of a gas
cloud associated with the asymmetric spiral galaxy NGC 2442. This object,
designated HIPASS J0731-69, contains ~10^9 M_sun of HI, or nearly one-third as
much atomic gas as NGC 2442 itself. No optical counterpart to any part of
HIPASS J0731-69 has yet been identified, consistent with the gas being diffuse,
and with its stream-like kinematics. If the gas in HIPASS J0731-69 was once
part of NGC 2442, then it was most likely a fairly recent tidal encounter with
a moderately massive companion which tore it loose, although the possibility of
ram-pressure stripping cannot be ruled out. This discovery highlights the
potential of the HIPASS data for yielding new clues to the nature of some of
the best-known galaxies in the local universe.Comment: 8 pages, 4 figures, uses "emulateapj5.sty". Accepted for publication
in ApJ, Vol. 555, 1 July 2001. Figs 1 and 2 included as JPE
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