23 research outputs found
Synthesis and biological evaluation of thielocin B1 analogues as protein-protein interaction inhibitors of PAC3 homodimer
Rehabilitation Exercises to Induce Balanced Scapular Muscle Activity in an Anti-gravity Posture
[Purpose] The purpose of this study was to compare the intramuscular balance ratios of the upper trapezius muscle (UT) and the lower trapezius muscle (LT), and the intermuscular balance ratios of the UT and the serratus anterior muscle (SA) among prone extension (ProExt), prone horizontal abduction with external rotation (ProHAbd), forward flexion in the side-lying position (SideFlex), side-lying external rotation (SideEr), shoulder flexion with glenohumeral horizontal abduction load (FlexBand), and shoulder flexion with glenohumeral horizontal adduction load (FlexBall) in the standing posture. [Methods] The electromyographic (EMG) activities of the UT, LT and SA were measured during the tasks. The percentage of maximum voluntary isometric contraction (% MVIC) was calculated for each muscle, and the UT/LT ratios and the UT/SA ratios were compared among the tasks. [Results] The UT/LT ratio with the FlexBand was not significantly different from those of the four exercises in the side-lying and prone postures. The UT/SA ratio with the FlexBall demonstrated appropriate balanced activity. [Conclusion] In an anti-gravity posture, we recommend the FlexBand and the FlexBall for inducing balanced UT/LT and UT/SA ratios, respectively
Kinetics Study of Heterogeneous Bromine Release from the Reaction between Gaseous Ozone and Aqueous Bromide Solution
The heterogeneous
release of molecular bromine, Br<sub>2</sub>,
from the reaction between gaseous ozone and aqueous bromide ion in
seawater ice and sea salt aerosols is considered to be an initial
source of reactive bromine species in the troposphere. Recent studies
have demonstrated that the uptake of ozone by aqueous bromide solution
is promoted by reactions at the gas–liquid interface. The present
work investigated the heterogeneous reaction between gaseous ozone
and aqueous bromide solution at atmospheric pressure and room temperature
using a wetted wall flow reactor combined with a chemical ionization
mass spectrometer. The emission rate of Br<sub>2</sub> was measured
as a function of gaseous ozone concentration, aqueous bromide concentration,
and pH. In addition, we conducted a simple kinetics model simulation
that included only bulk aqueous-phase reactions and compared the theoretical
values with the experimentally determined values. The Br<sub>2</sub> emission rates measured experimentally differ from the simulated
rates at relatively high bromide concentration, as well as in the
pH region of 6–9. These differences might be explained by different
Br<sup>–</sup> concentration and/or deprotonation efficiency
near the interface region and those in the bulk solution
Trichostatin Analogues JBIR-109, JBIR-110, and JBIR-111 from the Marine Sponge-Derived Streptomyces sp. RM72
Three new trichostatin analogues, JBIR-109 (<b>1</b>), JBIR-110
(<b>2</b>), and JBIR-111 (<b>3</b>), were isolated from
the culture of the marine sponge-derived <i>Streptomyces</i> sp. strain RM72, together with trichostatin A (<b>4</b>) and
trichostatic acid (<b>5</b>). The planar structures of <b>1</b>–<b>3</b> were determined on the basis of extensive
NMR and MS analyses. In addition, the absolute configurations of the
amino acid residues were determined by Marfey’s method. The
histone deacetylase
inhibitory activities of <b>1</b>–<b>5</b> were
examined, and their structure–activity relationships are discussed