MFG-E8 Regulates Angiogenesis in Cutaneous Wound Healing

Our research group recently demonstrated that pericytes are major sources of the secreted glycoprotein and integrin ligand lactadherin (MFG-E8) in B16 melanoma tumors, and that MFG-E8 promotes angiogenesis via enhanced PDGF–PDGFRβ signaling mediated by integrin–growth factor receptor crosstalk. However, sources of MFG-E8 and its possible roles in skin physiology are not well characterized. The objective of this study was to characterize the involvement of MFG-E8 in skin wound healing. In the dermis of normal murine and human skin, accumulations of MFG-E8 were found around CD31+ blood vessels, and MFG-E8 colocalized with PDGFRβ+, αSMA+, and NG2+ pericytes. MFG-E8 protein and mRNA levels were elevated in the dermis during full-thickness wound healing in mice. MFG-E8 was diffusely present in granulation tissue and was localized around blood vessels. Wound healing was delayed in MFG-E8 knockout mice, compared with the wild type, and myofibroblast and vessel numbers in wound areas were significantly reduced in knockout mice. Inhibition of MFG-E8 production with siRNA attenuated the formation of capillary-like structures in vitro. Expression of MFG-E8 in fibrous human granulation tissue with scant blood vessels was less than that in granulation tissue with many blood vessels. These findings suggest that MFG-E8 promotes cutaneous wound healing by enhancing angiogenesis

Development of tinea corporis in a Japanese patient with atopic dermatitis under treatment with upadacitinib in a real‐world clinical setting: Possible contribution of the suppression of Th17

We present a rare case of a patient with AD who developed tinea corporis during upadacitinib treatment in a real‐world clinical setting. We hypothesized that the suppressive effect of Th17 immunity by upadacitinib possibly has contributed to the development of tinea corporis

A case of disseminated extranodal Rosai–Dorfman disease diagnosed by skin manifestations

Abstract Rosai–Dorfman disease (RDD) is a rare non‐Langerhans cell histiocytosis that was first described as sinus histiocytosis with massive lymphadenopathy by Rosai and Dorfman in 1969. While classical/nodal RDD is typical, extranodal involvement is seen in up to 43% of all cases, with 23% showing only extranodal lesions. Here, we present a case of disseminated extranodal RDD, where the initial symptoms were cutaneous manifestations

Geranium sibiricum L. var. glabrius Ohwi

原著和名: イチゲフウロ科名: フウロソウ科 = Geraniaceae採集地: 北海道 苫小牧市北部 (北海道 胆振 苫小牧北部)採集日: 1985/8/28採集者: 萩庭丈壽整理番号: JH026508国立科学博物館整理番号: TNS-VS-97650

Photo absorption coefficient of oxyhemoglobin and deoxyhemoglobin.

<p>Photo absorption coefficient of oxyhemoglobin and deoxyhemoglobin.</p

<i>ΔC</i>_<i>Hb</i> measured in four healthy volunteers and four scleroderma patients.

<p><i>ΔC</i>_<i>Hb</i> measured in four healthy volunteers and four scleroderma patients.</p

An index of blood reflow characteristic <i>ΔC</i>_<i>Hb</i>.

<p>An index of blood reflow characteristic <i>ΔC</i>_<i>Hb</i>.</p