A mediating effect on erp km model for the performance of oil and gas sector in klang valley: A preliminary study

The development of information technology and the internet has created a borderless business environment and increased market competition. Driving globalization trends, information technology facilitates the organization in the aspect of the decision-making process, increasing productivity with cost-effective and fast delivery to meet customer needs. This article presents a conceptual study of ERP KM model and proposes a direction for further investigation. In this study, a literature review on Incentive as mediating effects in ERP KM model against operational and financial performance was analyzed. In order to achieve this target, to maintain the competitive advantage, oil and gas industry players implement Knowledge Management (KM) on Enterprise Resource Planning (ERP) systems. However, most studies focus only on the implementation and improvement of the ERP process flows as compared to KM concepts. This paper covers literary studies related to KM and ERP as well as merging these two concepts to form the appropriate ERP KM model for the oil and gas sector in Klang Valley, Malaysia. The new model of ERP KM Rizam 2019 introduced in this study will be tested for its effectiveness in the oil and gas sector especially in the Klang Valley. It was found that the mediating effect ‘Incentives’ in addition to KM is expected to have a positive relationship on operational and financial performance compared to the direct influences of ERP usage on performance. © 2019, World Academy of Research in Science and Engineering. All rights reserved

A 7 year old girl with anemia and massive hepatosplenomegaly

This article has no abstract. The first 100 words appear below:A 7 year old girl reported to the child outpatient department of a military hospital in Chittagong (South-East part of Bangladesh) Cantonment with the complaints of generalized weakness, loss of appe-tite, gradual distention of the abdomen and weight loss. The child was reasonably well and performing all her daily activities at her own 1 year before. She was also going to the school regularly and was worried when her parents noticed the distension of her abdomen and reluctant to take food adequately. The child also developed weakness and witnessed weight loss. At that time, there was no history of fever, jaundice, vomiting, hematemesis and melena

A review on mechanism of action, resistance, synergism, and clinical implications of mupirocin against Staphylococcus aureus

Mupirocin (MUP), bactroban, or pseudomonic acid is a natural crotonic acid derivative drug extracted from Pseudomonas fluorescens which is produced by modular polyketide synthases. This antibiotic has a unique chemical structure and mechanism of action. It is a mixture of A�D pseudomonic acids and inhibits protein synthesis through binding to bacterial isoleucyl-tRNA synthetase. MUP is often prescribed to prevent skin and soft tissue infections caused by S. aureus isolates and where the MRSA isolates are epidemic, MUP may be used as a choice drug for nasal decolonization. It is also used for prevention of recurring infections and control the outbreaks. The emergence of MUP resistance has been increasing particularly among methicillin-resistant Staphylococcus aureus (MRSA) isolates in many parts of the world and such resistance is often related with MUP widespread uses. Although both low-level and high-level MUP resistance were reported among MRSA isolates, the rate of resistance is different in various geographic areas. In this review, we will report the global prevalence of MUP resistance, discuss synergism and mechanism of action of MUP, and provide new insights into the clinical use of this antibiotic. © 2018 Elsevier Masson SA

Bedaquiline: Current status and future perspectives

The development of drug-resistant tuberculosis (TB) is a major threat worldwide. Based on World Health Organization (WHO) reports, it is estimated that more than 500 000 new cases of drug-resistant TB occur annually. In addition, there are alarming reports of increasing multidrug-resistant TB (MDR-TB) and the emergence of extensively drug-resistant TB (XDR-TB) from different countries of the world. Therefore, new options for TB therapy are required. Bedaquiline (BDQ), a novel anti-TB drug, has significant minimum inhibitory concentrations (MICs) both against drug-susceptible and drug-resistant TB. Moreover, BDQ was recently approved for therapy of MDR-TB. The current narrative review summarises the available data on BDQ resistance, describes its antimicrobial properties, and provides new perspectives on clinical use of this novel anti-TB agent. © 2021 The Author(s

A Comprehensive Review of the Protein Subunit Vaccines Against COVID-19

Two years after severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), in December 2019, the first infections were identified in Wuhan city of China. SARS-CoV-2 infection caused a global pandemic and accordingly, 5.41 million deaths worldwide. Hence, developing a safe and efficient vaccine for coronavirus disease 2019 (COVID-19) seems to be an urgent need. Attempts to produce efficient vaccines inexhaustibly are ongoing. At present time, according to the COVID-19 vaccine tracker and landscape provided by World Health Organization (WHO), there are 161 vaccine candidates in different clinical phases all over the world. In between, protein subunit vaccines are types of vaccines that contain a viral protein like spike protein or its segment as the antigen assumed to elicit humoral and cellular immunity and good protective effects. Previously, this technology of vaccine manufacturing was used in a recombinant influenza vaccine (RIV4). In the present work, we review protein subunit vaccines passing their phase 3 and 4 clinical trials, population participated in these trials, vaccines manufactures, vaccines efficiency and their side effects, and other features of these vaccines

Molecular evaluation of aminoglycosides resistance and biofilm formation in Klebsiella pneumoniae clinical isolates: A cross-sectional study

Background and AimsResistance to antibiotics and the capability to develop biofilm as two main virulent determinants of Klebsiella pneumoniae have important role in infection persistence. The aim of the study was to evaluate the association between the prevalence of aminoglycoside resistance and virulence genes and biofilm formation capacity in K. pneumoniae strains isolated from hospitalized patients in South-West of Iran. MethodsA total of 114 non-duplicate clinical isolates of K. pneumoniae collected from Ahvaz teaching hospitals. Identification of species was performed by biochemical tests and then confirmed by polymerase chain reaction (PCR) of rpoB gene. The susceptibility to antibiotics was determined by Kirby-Bauer disk diffusion method. Biofilm formation was assessed by microtiter plate method. Finally, PCR was conducted to detect virulence gene determinants including fimbrial genes, aminoglycoside modifying enzymes- and 16S rRNA methylase (RMTase) genes. ResultsTotally, all collected strains were carbapenem resistant and showed multidrug- and extensively drug-resistance phenotype (75 and 25, respectively). Seventy-one percent (n = 81) of isolates were non-susceptible to aminoglycosides. Among aminoglycoside antibiotics, K. pneumoniae isolates showed the highest and lowest resistance rates to tobramycin (71) and the amikacin (25), respectively. All biofilm producer strains were positive for the presence virulence determinants including ecpA, fimA, mrkD, and mrkA. Of 81 aminoglycosides non-susceptible isolates 33 were positive for the presence ant (2 '')-Ia as the most prevalent gene followed by aac (3 ')-IIa and armA (27), aac (6 ')-Ib (18), and aph (3 ')-Ia (15). ConclusionK. pneumoniae isolates showed the highest and the lowest aminoglycoside resistance rates to tobramycin and amikacin, respectively. Majority of isolates were biofilm producers and there was significant association between antibiotic resistance pattern and the strength of biofilm production. The ant(2 '')-Ia, aac (3 ')-IIa, and armA genes in aminoglycoside-resistant isolates

Mechanism of action, resistance, synergism, and clinical implications of azithromycin

Background Azithromycin (AZM), sold under the name Zithromax, is classified as a macrolide. It has many benefits due to its immunomodulatory, anti-inflammatory, and antibacterial effects. This review aims to study different clinical and biochemisterial aspects and properties of this drug which has a priority based on literature published worldwide. Methods Several databases including Web of Science, Google Scholar, PubMed, and Scopus were searched to obtain the relevant studies. Results AZM mechanism of action including the inhibition of bacterial protein synthesis, inhibition of proinflammatory cytokine production, inhibition of neutrophil infestation, and macrophage polarization alteration, gives it the ability to act against a wide range of microorganisms. Resistant organisms are spreading and being developed because of the irrational use of the drug in the case of dose and duration. AZM shows synergistic effects with other drugs against a variety of organisms. This macrolide is considered a valuable antimicrobial agent because of its use as a treatment for a vast range of diseases such as asthma, bronchiolitis, COPD, cystic fibrosis, enteric infections, STIs, and periodontal infections. Conclusions Our study shows an increasing global prevalence of AZM resistance. Thus, synergistic combinations are recommended to treat different pathogens. Moreover, continuous monitoring of AZM resistance by registry centers and the development of more rapid diagnostic assays are urgently needed

A 7 year old girl with anemia and massive hepatosplenomegaly

This article has no abstract. The first 100 words appear below: A 7 year old girl reported to the child outpatient department of a military hospital in Chittagong (South-East part of Bangladesh) Cantonment with the complaints of generalized weakness, loss of appe-tite, gradual distention of the abdomen and weight loss. The child was reasonably well and performing all her daily activities at her own 1 year before. She was also going to the school regularly and was worried when her parents noticed the distension of her abdomen and reluctant to take food adequately. The child also developed weakness and witnessed weight loss. At that time, there was no history of fever, jaundice, vomiting, hematemesis and melena

A 7 year old girl with anemia and massive hepatosplenomegaly

This article has no abstract. The first 100 words appear below: A 7 year old girl reported to the child outpatient department of a military hospital in Chittagong (South-East part of Bangladesh) Cantonment with the complaints of generalized weakness, loss of appe-tite, gradual distention of the abdomen and weight loss. The child was reasonably well and performing all her daily activities at her own 1 year before. She was also going to the school regularly and was worried when her parents noticed the distension of her abdomen and reluctant to take food adequately. The child also developed weakness and witnessed weight loss. At that time, there was no history of fever, jaundice, vomiting, hematemesis and melena