290 research outputs found
DC field induced enhancement and inhibition of spontaneous emission in a cavity
We demonstrate how spontaneous emission in a cavity can be controlled by the
application of a dc field. The method is specially suitable for Rydberg atoms.
We present a simple argument for the control of emission.Comment: 3-pages, 2figure. accepted in Phys. Rev.
Protein complex from human milk enhances the activity of antibiotics and drugs against Mycobacterium tuberculosis.
Mycobacterium tuberculosis, the causative agent of human tuberculosis (TB), has surpassed HIV/AIDS as the leading cause of death from a single infectious agent. The increasing occurrence of drug-resistant strains has become a major challenge for health care systems and, in some cases, has rendered TB untreatable. However, the development of new TB drugs has been plagued with high failure rates and costs. Alternative strategies to increase the efficacy of current TB treatment regimens include host-directed therapies or agents that make M. tuberculosis more susceptible to existing TB drugs. In this study, we show that HAMLET, an α-lactalbumin-oleic acid complex derived from human milk, has bactericidal activity against M. tuberculosis HAMLET consists of a micellar oleic acid core surrounded by a shell of partially denatured α-lactalbumin molecules and unloads oleic acid into cells upon contact with lipid membranes. At sublethal concentrations, HAMLET potentiated a remarkably broad array of TB drugs and antibiotics against M. tuberculosis For example, the minimal inhibitory concentrations of rifampin, bedaquiline, delamanid, and clarithromycin were decreased by 8- to 16-fold. HAMLET also killed M. tuberculosis and enhanced the efficacy of TB drugs inside macrophages, a natural habitat of M. tuberculosis Previous studies showed that HAMLET is stable after oral delivery in mice and nontoxic in humans and that it is possible to package hydrophobic compounds in the oleic acid core of HAMLET to increase their solubility and metabolic stability. The potential of HAMLET and other liprotides as drug delivery and sensitization agents in TB chemotherapy is discussed here.Microbiology and Molecular Genetic
Non-Markovian Dynamics of Entanglement for Multipartite Systems
Entanglement dynamics for a couple of two-level atoms interacting with
independent structured reservoirs is studied using a non-perturbative approach.
It is shown that the revival of atom entanglement is not necessarily
accompanied by the sudden death of reservoir entanglement, and vice versa. In
fact, atom entanglement can revive before, simultaneously or even after the
disentanglement of reservoirs. Using a novel method based on the population
analysis for the excited atomic state, we present the quantitative criteria for
the revival and death phenomena. For giving a more physically intuitive
insight, the quasimode Hamiltonian method is applied. Our quantitative analysis
is helpful for the practical engineering of entanglement.Comment: 10 pages and 4 figure
Multi-Modal Properties and Dynamics of the Gradient Echo Quantum Memory
We investigate the properties of a recently proposed Gradient Echo Memory
(GEM) scheme for information mapping between optical and atomic systems. We
show that GEM can be described by the dynamic formation of polaritons in
k-space. This picture highlights the flexibility and robustness with regards to
the external control of the storage process. Our results also show that, as GEM
is a frequency-encoding memory, it can accurately preserve the shape of signals
that have large time-bandwidth products, even at moderate optical depths. At
higher optical depths, we show that GEM is a high fidelity multi-mode quantum
memory.Comment: 4 pages 3 figure
Scaling properties of cavity-enhanced atom cooling
We extend an earlier semiclassical model to describe the dissipative motion
of N atoms coupled to M modes inside a coherently driven high-finesse cavity.
The description includes momentum diffusion via spontaneous emission and cavity
decay. Simple analytical formulas for the steady-state temperature and the
cooling time for a single atom are derived and show surprisingly good agreement
with direct stochastic simulations of the semiclassical equations for N atoms
with properly scaled parameters. A thorough comparison with standard free-space
Doppler cooling is performed and yields a lower temperature and a cooling time
enhancement by a factor of M times the square of the ratio of the atom-field
coupling constant to the cavity decay rate. Finally it is shown that laser
cooling with negligible spontaneous emission should indeed be possible,
especially for relatively light particles in a strongly coupled field
configuration.Comment: 7 pages, 5 figure
Vacuum-stimulated cooling of single atoms in three dimensions
Taming quantum dynamical processes is the key to novel applications of
quantum physics, e.g. in quantum information science. The control of
light-matter interactions at the single-atom and single-photon level can be
achieved in cavity quantum electrodynamics, in particular in the regime of
strong coupling where atom and cavity form a single entity. In the optical
domain, this requires permanent trapping and cooling of an atom in a
micro-cavity. We have now realized three-dimensional cavity cooling and
trapping for an orthogonal arrangement of cooling laser, trap laser and cavity
vacuum. This leads to average single-atom trapping times exceeding 15 seconds,
unprecedented for a strongly coupled atom under permanent observation.Comment: 4 pages, 4 figure
Trapping and cooling single atoms with far-off resonance intracavity doughnut modes
We investigate cooling and trapping of single atoms inside an optical cavity
using a quasi-resonant field and a far-off resonant mode of the Laguerre-Gauss
type. The far-off resonant doughnut mode provides an efficient trapping in the
case when it shifts the atomic internal ground and excited state in the same
way, which is particularly useful for quantum information applications of
cavity quantum electrodynamics (QED) systems. Long trapping times can be
achieved, as shown by full 3-D simulations of the quasi-classical motion inside
the resonator.Comment: 18 pages, 18 figures, RevTe
Trapping of Single Atoms with Single Photons in Cavity QED
Two recent experiments have reported the trapping of individual atoms inside
optical resonators by the mechanical forces associated with single photons
[Hood et al., Science 287, 1447 (2000) and Pinkse et al., Nature 404, 365
(2000)]. Here we analyze the trapping dynamics in these settings, focusing on
two points of interest. Firstly, we investigate the extent to which
light-induced forces in these experiments are distinct from their free-space
counterparts. Secondly, we explore the quantitative features of the resulting
atomic motion and how these dynamics are mapped onto variations of the
intracavity field. Not surprisingly, qualitatively distinct atomic dynamics
arise as the coupling and dissipative rates are varied. For the experiment of
Hood et al., we show that atomic motion is largely conservative and is
predominantly in radial orbits transverse to the cavity axis. A comparison with
the free-space theory demonstrates that the fluctuations of the dipole force
are suppressed by an order of magnitude. This effect is based upon the
Jaynes-Cummings eigenstates of the atom-cavity system and represents
qualitatively new physics for optical forces at the single-photon level. By
contrast, even in a regime of strong coupling in the experiment of Pinkse et
al., there are only small quantitative distinctions between the free-space
theory and the quantum theory, so it is not clear that description of this
experiment as a novel single-quantum trapping effect is necessary. The atomic
motion is strongly diffusive, leading to an average localization time
comparable to the time for an atom to transit freely through the cavity and to
a reduction in the ability to infer aspects of the atomic motion from the
intracavity photon number.Comment: 19 pages, 22 figure files, REVTEX, corrected spelling, LaTeX now
produces postscript which includes figures, minor changes to figures. Final
version to be published in Physical Review A, expanded summary of results in
introduction, minor changes to figures and tex
Jacobi Identity for Vertex Algebras in Higher Dimensions
Vertex algebras in higher dimensions provide an algebraic framework for
investigating axiomatic quantum field theory with global conformal invariance.
We develop further the theory of such vertex algebras by introducing formal
calculus techniques and investigating the notion of polylocal fields. We derive
a Jacobi identity which together with the vacuum axiom can be taken as an
equivalent definition of vertex algebra.Comment: 35 pages, references adde
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