Enabling Space Exploration Medical System Development Using a Tool Ecosystem

The NASA Human Research Program's (HRP) Exploration Medical Capability (ExMC) Element is utilizing a Model Based Systems Engineering (MBSE) approach to enhance the development of systems engineering products that will be used to advance medical system designs for exploration missions beyond Low Earth Orbit. In support of future missions, the team is capturing content such as system behaviors, functional decompositions, architecture, system requirements and interfaces, and recommendations for clinical capabilities and resources in Systems Modeling Language (SysML) models. As these products mature, SysML models provide a way for ExMC to capture relationships among the various products, which includes supporting more integrated and multi-faceted views of future medical systems. In addition to using SysML models, HRP and ExMC are developing supplementary tools to support two key functions: 1) prioritizing current and future research activities for exploration missions in an objective manner; and 2) enabling risk-informed and evidence-based trade space analysis for future space vehicles, missions, and systems. This paper will discuss the long-term HRP and ExMC vision for the larger ecosystem of tools, which include dynamic Probabilistic Risk Assessment (PRA) capabilities, additional SysML models, a database of system component options, and data visualizations. It also includes a review of an initial Pilot Project focused on enabling medical system trade studies utilizing data that is coordinated across tools for consistent outputs (e.g., mission risk metrics that are associated with medical system mass values and medical conditions addressed). This first Pilot Project demonstrated successful operating procedures and integration across tools. Finally, the paper will also cover a second Pilot Project that utilizes tool enhancements such as medical system optimization capabilities, post-processing, and visualization of generated data for subject matter expert review, and increased integration amongst the tools themselves

breast cancer in young women climbing for progress in care and knowledge

Approximately a third of newly diagnosed invasive breast cancers occur in women aged under 50 years and it is likely that the incidence of the disease in younger women will further increase as a result of demographic and lifestyle changes and progress in screening. Breast cancer in young women is different from that in older patients. Young women with breast cancer represent a distinct population for which tailored diagnostic, therapeutic and supportive interventions are required. This review highlights the complex diagnostic and therapeutic processes that women and care providers are faced with. Topics addressed include the need for more sensitive and specific diagnostic tools that are capable of detecting cancer in dense breasts, the development of individualized surgical and medical treatments in the early and advanced disease setting aimed at improving outcome and reducing long-term side effects, and adequate psychosocial interventions