Letter From Esther Moser to Alfred L. Shoemaker, October 19, 1953

A handwritten letter from Esther Moser addressed to Alfred L. Shoemaker, dated October 19, 1953. Within, Moser responds to an inquiry made in Shoemaker\u27s radio program and provides a Pennsylvania Dutch rhyme entitled Schlummer Gabade.https://digitalcommons.ursinus.edu/shoemaker_documents/1065/thumbnail.jp

Letter From Esther Moser to Alfred L. Shoemaker, September 14, 1953

A handwritten letter from Esther Moser addressed to Alfred L. Shoemaker, dated September 14, 1953. Within, Moser provides a number of old sayings, rhymes and tongue twisters from Bally township in Pennsylvania Dutch dialect. She also suggests that Shoemaker visit John Yerger in Bechtelsville.https://digitalcommons.ursinus.edu/shoemaker_documents/1018/thumbnail.jp

Letter From Esther Moser to Alfred L. Shoemaker, March 23, 1953

A handwritten letter from Esther Moser addressed to Alfred L. Shoemaker, dated March 23, 1953. Within, Moser writes on a number of subjects including bird and animal sayings, St. Gregory\u27s Day, and recipes for dishes involving ham and dough.https://digitalcommons.ursinus.edu/shoemaker_documents/1035/thumbnail.jp

Series: Public engagement with research. Part 1: The fundamentals of public engagement with research

BACKGROUND: In the first of a four-part series, we describe the fundamentals of public engagement in primary care research. OBJECTIVES: The article's purpose is to encourage, inform and improve the researcher's awareness about public engagement in research. For a growing number of researchers, funders and patient organisations in Europe, public engagement is a moral and ethical imperative for conducting high-quality research. DISCUSSION: Starting with an explanation of the role of public engagement in research, we highlight its diversity and benefits to research, researchers and the public members involved. We summarise principles of good practice and provide valuable resources for researchers to use in their public engagement activities. Finally, we discuss some of the issues encountered when researchers collaborate with members of the public and provide practical steps to address them. Case studies of real-life situations are used to illustrate and aid understanding. CONCLUSION: We hope this article and the other papers in this series will encourage researchers to better consider the role and practice of public engagement and the potential added value to research that collaborating with the public could provide

A functional yeast survival screen of tumor-derived cDNA libraries designed to identify anti-apoptotic mammalian oncogenes

Yeast cells can be killed upon expression of pro-apoptotic mammalian proteins. We have established a functional yeast survival screen that was used to isolate novel human anti-apoptotic genes overexpressed in treatment-resistant tumors. The screening of three different cDNA libraries prepared from metastatic melanoma, glioblastomas and leukemic blasts allowed for the identification of many yeast cell death-repressing cDNAs, including 28% of genes that are already known to inhibit apoptosis, 35% of genes upregulated in at least one tumor entity and 16% of genes described as both anti-apoptotic in function and upregulated in tumors. These results confirm the great potential of this screening tool to identify novel anti-apoptotic and tumor-relevant molecules. Three of the isolated candidate genes were further analyzed regarding their anti-apoptotic function in cell culture and their potential as a therapeutic target for molecular therapy. PAICS, an enzyme required for de novo purine biosynthesis, the long non-coding RNA MALAT1 and the MAST2 kinase are overexpressed in certain tumor entities and capable of suppressing apoptosis in human cells. Using a subcutaneous xenograft mouse model, we also demonstrated that glioblastoma tumor growth requires MAST2 expression. An additional advantage of the yeast survival screen is its universal applicability. By using various inducible pro-apoptotic killer proteins and screening the appropriate cDNA library prepared from normal or pathologic tissue of interest, the survival screen can be used to identify apoptosis inhibitors in many different systems

Revisiting Glauconite Geochronology: Lessons Learned from In Situ Radiometric Dating of a Glauconite-Rich Cretaceous Shelfal Sequence

The scarcity of well-preserved and directly dateable sedimentary sequences is a major impediment to inferring the Earth’s paleo-environmental evolution. The authigenic mineral glauconite can potentially provide absolute stratigraphic ages for sedimentary sequences and constraints on paleo-depositional conditions. This requires improved approaches for measuring and interpreting glauconite formation ages. Here, glauconite from a Cretaceous shelfal sequence (Langenstein, northern Germany) was characterized using petrographical, geochemical (EMP), andmineralogical (XRD) screening methods before in situ Rb-Sr dating via LA-ICP-MS/MS. The obtained glauconite ages (~101 to 97 Ma) partly overlap with the depositional age of the Langenstein sequence (±3 Ma), but without the expected stratigraphic age progression, which we attribute to detrital and diagenetic illitic phase impurities inside the glauconites. Using a novel age deconvolution approach, which combines the new Rb-Sr dataset with published K-Ar ages, we recalculate the glauconite bulk ages to obtain stratigraphically significant ‘pure’ glauconite ages (~100 to 96 Ma). Thus, our results show that pristine ages can be preserved in mineralogically complex glauconite grains even under burial diagenetic conditions (T < 65 ◦C; <1500 m depth), confirming that glauconite could be a suitable archive for paleo-environmental reconstructions and direct sediment dating.Esther Scheiblhofer, Ulrike Moser, Stefan Löhr, Markus Wilmsen, Juraj Farkaš, Daniela Gallhofer, Alice Matsdotter Bäckström, Thomas Zack, and Andre Balderman

The Interplay of “Big Five ” Personality Factors and Metaphorical Schemas: A Pilot Study with 20 Lung Transplant Recipients

The Qualitative Report Volume 12 Number 3 September 2007 397-413 http://www.nova.edu/ssss/QR/QR12-3/goetzmann.pdf The Interplay of “Big Five ” Personality Factors and Metaphorical Schemas: A Pilot Study with 20 Lung Transplant Recipients Lutz Goetzmann University Hospital Zurich, Zurich, Switzerland Karin S. Moser Roehampton University, London Esther Vetsch, Erhard Grieder, Richard Klaghofer, Rahel Naef, Erich W. Russi, Annette Boehler, and Claus Buddeberg University Hospital Zurich, Zurich, Switzerland The aim of the present study was to investigate the interplay between personality factors and metaphorical schemas. The “Big Five” personality factors of 20 patients after lung transplantation were examined with the NEO-FFI. Patients were questioned about their social network , and self- and body-image. The interviews were assessed with metaphor analysis. Significant positive correlations were found between “extraversion” and metaphors for acoustics, play/sport and economy, furthermore between “openness to experience” and metaphors for acoustics, container, battle, illness. A positive correlation was also found between “openness to experience” and metaphor frequency. Significant negative correlations were found between “conscientiousness” and metaphors for illness. The results indicate that personality factors may correspond with certain implicit metaphorical schemas

Innovative models for collaboration and student mobility in Europe

This report is based on new developments in higher education and international collaboration as collected by EADTU's Task Force and Peer Learning Activity on Virtual Mobility. The result is a report on three types of collaboration mobility: physical, blended and online. Main parameters for innovative education and mobility formats are defined as well as basic principles of international course and curriculum design. Examples illustrate the complete opportunity space between fully face to face and fully online collaboration. They relate to mobility within single courses, exchange mobility (classical Erasmus), networked programmes and mobility windows and joint programmes with embedded mobility. Mobility offers opportunities to institutions to strengthen their programmes and to students to enrich their study. They benefit from an international learning experience or following courses not provided by their own institution. The report shows concrete mobility schemes used in the membership (and beyond). It underpins policies for international networking and delivers tools to organise innovative education and mobility formats

The Pennsylvania Dutchman Vol. 8, No. 1

● The Summer House ● Drinks in Dutchland ● Yesteryear in Dutchland ● Moshey and Bellyguts ● Rise of Interest in Dutch Antiques ● Diaper Lore ● Lititz ● Witchcraft in Cow and Horse ● Dorothy Kalbach ● Plain Dutch and Gay Dutch ● Dialect Folksay ● Pennsylvania Dutch Pioneers ● About the Authors ● What\u27s New in Dutchlandhttps://digitalcommons.ursinus.edu/dutchmanmag/1008/thumbnail.jp