A Case-Based Exploration of Task/Technology Fit in a Knowledge Management Context

Task/Technology Fit (TTF) posits that as the intersection of the task domain and the capabilities of an information system (IS) increases in magnitude, the performance gains experienced by user through use of the IS will be positively impacted. While rooted in the traditional IS literature, this research proposes that TTF be extended to incorporate additional factors unique to the context of Knowledge Management (KM). Based upon the findings of this research, it is reasonable to conclude that when employing the TTF model to determine KMS fitness, additional factors other than the task requirements and KMS capabilities should be considered. This research also shows that the social ecology present within the organization has significant impacts on KMS fit. Finally, this research lends credibility to the idea that KMS are indeed a unique subset of IS and that traditional IS models (such as TTF) should reflect the unique social nature of KM

Scheduling for Weighted Flow and Completion Times in Reconfigurable Networks

New optical technologies offer the ability to reconfigure network topologies dynamically, rather than setting them once and for all. This is true in both optical wide area networks (optical WANs) and in datacenters, despite the many differences between these two settings. Because of these new technologies, there has been a surge of both practical and theoretical research on algorithms to take advantage of them. In particular, Jia et al. [INFOCOM '17] designed online scheduling algorithms for dynamically reconfigurable topologies for both the makespan and sum of completion times objectives. In this paper, we work in the same setting but study an objective that is more meaningful in an online setting: the sum of flow times. The flow time of a job is the total amount of time that it spends in the system, which may be considerably smaller than its completion time if it is released late. We provide competitive algorithms for the online setting with speed augmentation, and also give a lower bound proving that speed augmentation is in fact necessary. As a side effect of our techniques, we also improve and generalize the results of Jia et al. on completion times by giving an $O(1)$-competitive algorithm for arbitrary sizes and release times even when nodes have different degree bounds, and moreover allow for the weighted sum of completion times (or flow times).Comment: 10 pages. Appears in INFOCOM 202

Validation of a novel scoring system for changes in skeletal manifestations of hypophosphatasia in newborns, infants, and children: The Radiographic Global Impression of Change scale

Hypophosphatasia (HPP) is the heritable metabolic disease characterized by impaired skeletal mineralization due to low activity of the tissue-nonspecific isoenzyme of alkaline phosphatase. Although HPP during growth often manifests with distinctive radiographic skeletal features, no validated method was available to quantify them, including changes over time. We created the Radiographic Global Impression of Change (RGI-C) scale to assess changes in the skeletal burden of pediatric HPP. Site-specific pairs of radiographs of newborns, infants, and children with HPP from three clinical studies of asfotase alfa, an enzyme replacement therapy for HPP, were obtained at baseline and during treatment. Each pair was scored by three pediatric radiologists ( raters ), with nine raters across the three studies. Intrarater and interrater agreement was determined by weighted Kappa coefficients. Interrater reliability was assessed using intraclass correlation coefficients (ICCs) and by two-way random effects analysis of variance (ANOVA) and a mixed-model repeated measures ANOVA. Pearson correlation coefficients evaluated relationships of the RGI-C to the Rickets Severity Scale (RSS), Pediatric Outcomes Data Collection Instrument Global Function Parent Normative Score, Childhood Health Assessment Questionnaire Disability Index, 6-Minute Walk Test percent predicted, and Z-score for height in patients aged 6 to 12 years at baseline. Eighty-nine percent (8/9) of raters showed substantial or almost perfect intrarater agreement of sequential RGI-C scores (weighted Kappa coefficients, 0.72 to 0.93) and moderate or substantial interrater agreement (weighted Kappa coefficients, 0.53 to 0.71) in patients aged 0 to 12 years at baseline. Moderate-to-good interrater reliability was observed (ICC, 0.57 to 0.65). RGI-C scores were significantly (p ≤ 0.0065) correlated with the RSS and with measures of global function, disability, endurance, and growth in the patients aged 6 to 12 years at baseline. Thus, the RGI-C is valid and reliable for detecting clinically important changes in skeletal manifestations of severe HPP in newborns, infants, and children, including during asfotase alfa treatment. © 2018 The Authors. Journal of Bone and Mineral Research Published by Wiley Periodicals Inc

Severe Cholestasis Associated with Methyltestosterone: A Case Report

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/75504/1/j.1572-0241.1987.tb01706.x.pd

Pain:a statistical account

Perception is seen as a process that utilises partial and noisy information to construct a coherent understanding of the world. Here we argue that the experience of pain is no different; it is based on incomplete, multimodal information, which is used to estimate potential bodily threat. We outline a Bayesian inference model, incorporating the key components of cue combination, causal inference, and temporal integration, which highlights the statistical problems in everyday perception. It is from this platform that we are able to review the pain literature, providing evidence from experimental, acute, and persistent phenomena to demonstrate the advantages of adopting a statistical account in pain. Our probabilistic conceptualisation suggests a principles-based view of pain, explaining a broad range of experimental and clinical findings and making testable predictions

Motor Deficits Are Produced By Removing Some Cortical Transplants Grafted Into Injured Sensorimotor Cortex of Neonatal Rats

Fetal frontal cortex was transplanted into cavities formed in the right, motor cortex of neonatal rats. As adults, the animals were trained to press two levers in rapid succession with their left forelimb to receive food rewards. Once they had reached an optimal level of performance, the effect of removing their transplants was assessed. Surgical removal of transplants significantly impaired the performance of 2 of 4 subjects. Placing a crossstrain skin graft to induce the immunological rejection of the transplants produced a behavioral deficit in 1 of 2 subjects with complete transplant removal. Skin grafts produced no behavioral effects in four subjects that had surviving transplants. Since the motor deficit produced by transplant removal resembled those observed following the removal of normal motor cortex, we propose that these three transplants functioned within the host brain