2,502 research outputs found
A Silicon Surface Code Architecture Resilient Against Leakage Errors
Spin qubits in silicon quantum dots are one of the most promising building
blocks for large scale quantum computers thanks to their high qubit density and
compatibility with the existing semiconductor technologies. High fidelity
single-qubit gates exceeding the threshold of error correction codes like the
surface code have been demonstrated, while two-qubit gates have reached 98\%
fidelity and are improving rapidly. However, there are other types of error ---
such as charge leakage and propagation --- that may occur in quantum dot arrays
and which cannot be corrected by quantum error correction codes, making them
potentially damaging even when their probability is small. We propose a surface
code architecture for silicon quantum dot spin qubits that is robust against
leakage errors by incorporating multi-electron mediator dots. Charge leakage in
the qubit dots is transferred to the mediator dots via charge relaxation
processes and then removed using charge reservoirs attached to the mediators. A
stabiliser-check cycle, optimised for our hardware, then removes the
correlations between the residual physical errors. Through simulations we
obtain the surface code threshold for the charge leakage errors and show that
in our architecture the damage due to charge leakage errors is reduced to a
similar level to that of the usual depolarising gate noise. Spin leakage errors
in our architecture are constrained to only ancilla qubits and can be removed
during quantum error correction via reinitialisations of ancillae, which ensure
the robustness of our architecture against spin leakage as well. Our use of an
elongated mediator dots creates spaces throughout the quantum dot array for
charge reservoirs, measuring devices and control gates, providing the
scalability in the design
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Recent Advances in X-Ray Hydroxyl Radical Footprinting at the Advanced Light Source Synchrotron.
BackgroundSynchrotron hydroxyl radical footprinting is a relatively new structural method used to investigate structural features and conformational changes of nucleic acids and proteins in the solution state. It was originally developed at the National Synchrotron Light Source at Brookhaven National Laboratory in the late nineties, and more recently, has been established at the Advanced Light Source at Lawrence Berkeley National Laboratory. The instrumentation for this method is an active area of development, and includes methods to increase dose to the samples while implementing high-throughput sample delivery methods.ConclusionImproving instrumentation to irradiate biological samples in real time using a sample droplet generator and inline fluorescence monitoring to rapidly determine dose response curves for samples will significantly increase the range of biological problems that can be investigated using synchrotron hydroxyl radical footprinting
Constraints on the Obliquities of Kepler Planet-Hosting Stars
Stars with hot Jupiters have obliquities ranging from 0-180 degrees, but
relatively little is known about the obliquities of stars with smaller planets.
Using data from the California-Kepler Survey, we investigate the obliquities of
stars with planets spanning a wide range of sizes, most of which are smaller
than Neptune. First, we identify 156 planet hosts for which measurements of the
projected rotation velocity (vsini) and rotation period are both available. By
combining estimates of v and vsini, we find nearly all the stars to be
compatible with high inclination, and hence, low obliquity (less than about 20
degrees). Second, we focus on a sample of 159 hot stars (> 6000K) for which
vsini is available but not necessarily the rotation period. We find 6 stars for
which vsini is anomalously low, an indicator of high obliquity. Half of these
have hot Jupiters, even though only 3% of the stars that were searched have hot
Jupiters. We also compare the vsini distribution of the hot stars with planets
to that of 83 control stars selected without prior knowledge of planets. The
mean vsini of the control stars is lower than that of the planet hosts by a
factor of approximately pi/4, as one would expect if the planet hosts have low
obliquities. All these findings suggest that the Kepler planet-hosting stars
generally have low obliquities, with the exception of hot stars with hot
Jupiters.Comment: AJ, in pres
Bang-bang control of fullerene qubits using ultra-fast phase gates
Quantum mechanics permits an entity, such as an atom, to exist in a
superposition of multiple states simultaneously. Quantum information processing
(QIP) harnesses this profound phenomenon to manipulate information in radically
new ways. A fundamental challenge in all QIP technologies is the corruption of
superposition in a quantum bit (qubit) through interaction with its
environment. Quantum bang-bang control provides a solution by repeatedly
applying `kicks' to a qubit, thus disrupting an environmental interaction.
However, the speed and precision required for the kick operations has presented
an obstacle to experimental realization. Here we demonstrate a phase gate of
unprecedented speed on a nuclear spin qubit in a fullerene molecule (N@C60),
and use it to bang-bang decouple the qubit from a strong environmental
interaction. We can thus trap the qubit in closed cycles on the Bloch sphere,
or lock it in a given state for an arbitrary period. Our procedure uses
operations on a second qubit, an electron spin, in order to generate an
arbitrary phase on the nuclear qubit. We anticipate the approach will be vital
for QIP technologies, especially at the molecular scale where other strategies,
such as electrode switching, are unfeasible
Expression of KOC, S100P, mesothelin and MUC1 in pancreatico-biliary adenocarcinomas: development and utility of a potential diagnostic immunohistochemistry panel
<b>Background</b>
Pancreatico-biliary adenocarcinomas (PBA) have a poor prognosis. Diagnosis is usually achieved by imaging and/or endoscopy with confirmatory cytology. Cytological interpretation can be difficult especially in the setting of chronic pancreatitis/cholangitis. Immunohistochemistry (IHC) biomarkers could act as an adjunct to cytology to improve the diagnosis. Thus, we performed a meta-analysis and selected KOC, S100P, mesothelin and MUC1 for further validation in PBA resection specimens.<p></p>
<b>Methods</b>
Tissue microarrays containing tumour and normal cores in a ratio of 3:2, from 99 surgically resected PBA patients, were used for IHC. IHC was performed on an automated platform using antibodies against KOC, S100P, mesothelin and MUC1. Tissue cores were scored for staining intensity and proportion of tissue stained using a Histoscore method (range, 0–300). Sensitivity and specificity for individual biomarkers, as well as biomarker panels, were determined with different cut-offs for positivity and compared by summary receiver operating characteristic (ROC) curve.<p></p>
<b>Results</b>
The expression of all four biomarkers was high in PBA versus normal ducts, with a mean Histoscore of 150 vs. 0.4 for KOC, 165 vs. 0.3 for S100P, 115 vs. 0.5 for mesothelin and 200 vs. 14 for MUC1 (p < .0001 for all comparisons). Five cut-offs were carefully chosen for sensitivity/specificity analysis. Four of these cut-offs, namely 5%, 10% or 20% positive cells and Histoscore 20 were identified using ROC curve analysis and the fifth cut-off was moderate-strong staining intensity. Using 20% positive cells as a cut-off achieved higher sensitivity/specificity values: KOC 84%/100%; S100P 83%/100%; mesothelin 88%/92%; and MUC1 89%/63%. Analysis of a panel of KOC, S100P and mesothelin achieved 100% sensitivity and 99% specificity if at least 2 biomarkers were positive for 10% cut-off; and 100% sensitivity and specificity for 20% cut-off.<p></p>
<b>Conclusion</b>
A biomarker panel of KOC, S100P and mesothelin with at least 2 biomarkers positive was found to be an optimum panel with both 10% and 20% cut-offs in resection specimens from patients with PBA.<p></p>
Metallic 1T Phase, 3d1 Electronic Configuration and Charge Density Wave Order in Molecular Beam Epitaxy Grown Monolayer Vanadium Ditelluride.
We present a combined experimental and theoretical study of monolayer vanadium ditelluride, VTe2, grown on highly oriented pyrolytic graphite by molecular-beam epitaxy. Using various in situ microscopic and spectroscopic techniques, including scanning tunneling microscopy/spectroscopy, synchrotron X-ray and angle-resolved photoemission, and X-ray absorption, together with theoretical analysis by density functional theory calculations, we demonstrate direct evidence of the metallic 1T phase and 3d1 electronic configuration in monolayer VTe2 that also features a (4 × 4) charge density wave order at low temperatures. In contrast to previous theoretical predictions, our element-specific characterization by X-ray magnetic circular dichroism rules out a ferromagnetic order intrinsic to the monolayer. Our findings provide essential knowledge necessary for understanding this interesting yet less explored metallic monolayer in the emerging family of van der Waals magnets
Sustained Quantum Coherence and Entanglement in the Avian Compass
In artificial systems, quantum superposition and entanglement typically decay
rapidly unless cryogenic temperatures are used. Could life have evolved to
exploit such delicate phenomena? Certain migratory birds have the ability to
sense very subtle variations in Earth's magnetic field. Here we apply quantum
information theory and the widely accepted "radical pair" model to analyze
recent experimental observations of the avian compass. We find that
superposition and entanglement are sustained in this living system for at least
tens of microseconds, exceeding the durations achieved in the best comparable
man-made molecular systems. This conclusion is starkly at variance with the
view that life is too "warm and wet" for such quantum phenomena to endure.Comment: 4 pages, added journal referenc
Towards a fullerene-based quantum computer
Molecular structures appear to be natural candidates for a quantum
technology: individual atoms can support quantum superpositions for long
periods, and such atoms can in principle be embedded in a permanent molecular
scaffolding to form an array. This would be true nanotechnology, with
dimensions of order of a nanometre. However, the challenges of realising such a
vision are immense. One must identify a suitable elementary unit and
demonstrate its merits for qubit storage and manipulation, including input /
output. These units must then be formed into large arrays corresponding to an
functional quantum architecture, including a mechanism for gate operations.
Here we report our efforts, both experimental and theoretical, to create such a
technology based on endohedral fullerenes or 'buckyballs'. We describe our
successes with respect to these criteria, along with the obstacles we are
currently facing and the questions that remain to be addressed.Comment: 20 pages, 13 figs, single column forma
Evidence of Dynamical Spin Shielding in Ce from Spin-Resolved Photoelectron Spectroscopy
Using Fano effect measurements upon polycrystalline Ce, we have observed a phase reversal between the spectral structure at the Fermi edge and the other 4f derived feature near a binding energy of 2 eV. The Fano effect is the observation of spin polarized photoelectron emission from nonmagnetic materials, under chirally selective excitation, such as circularly polarized photons. The observation of phase reversal between the two peaks is a direct experimental proof of Kondo shielding in Ce, confirming the predictions of Gunnarsson and Shoenhammer, albeit with a small modification
Correction to Metallic 1T Phase, 3d1 Electronic Configuration and Charge Density Wave Order in Molecular-Beam Epitaxy Grown Monolayer Vanadium Ditelluride.
It has been brought to our attention that a mistake exists in the author list. The author “Johnson Goh” in the original article should be “Kuan Eng Johnson Goh”. His primary corresponding email is [email protected]
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