The physics and kinematics of the evolved, interacting planetary nebula PN G342.0-01.7

Here we aim to study the physical and kinematical characteristics of the unstudied old planetary nebula (PN) PN G342.0-01.7, which shows evidence of interaction with its surrounding interstellar medium. We used Integral Field Spectra from the Wide Field Spectrograph on the ANU 2.3 m telescope to provide spectroscopy across the whole object covering the spectral range 3400-7000 {\AA}. We formed narrow-band images to investigate the excitation structure. The spectral analysis shows that the object is a distant Peimbert Type I PN of low excitation, formally of excitation class of 0.5. The low electron density, high dynamical age, and low surface brightness of the object confirm that it is observed fairly late in its evolution. It shows clear evidence for dredge-up of CN-processed material characteristic of its class. In addition, the low peculiar velocity of 7 km s$^{-1}$ shows it to be a member of the young disk component of our Galaxy. We built a self-consistent photoionisation model for the PNe matching the observed spectrum, the H$\beta$ luminosity, and the diameter. On the basis of this we derive an effective temperature $\log T_{\rm eff} \sim 5.05$ and luminosity $1.85 < \log L < 2.25$. The temperature is much higher than might have been expected using the excitation class, proving that this can be misleading in classifying evolved PNe. PN G342.0-01.7 is in interaction with its surrounding interstellar medium through which the object is moving in the south-west direction. This interaction drives a slow shock into the outer PN ejecta. A shock model suggests that it only accounts for about 10\% of the total luminosity, but has an important effect on the global spectrum of the PN.Comment: 15 pages, 6 figures, A&A accepted 201

Geological and groundwater potential studies of El Ismailiya master plan study area

There are no author-identified significant results in this report

Control of root rot and wilt disease complex of some evergreen fruit transplants by using plant growth promoting rhizobacteria in the New Valley Governorate, Egypt

Root rot and wilt disease complex were detected in several guava, lemon and olive transplant nurseries and new orchards at El-Kharga, Baris, ballet, El-Dakhla and El-Farafrah districts, the New Valley Governorate, Egypt. The average percentage of root rot/wilt incidence and severity in surveying districts were 37.7, 26.5%in guava; 41.7, 34.0%;in lemon and 41.2, 29.5% in olive transplants, respectively. The most frequently isolated fungi from rotted roots of the guava, lemon and olive transplants were Fusarium oxysporum, F. solani, Macrophomina phaseolina and Rhizoctonia solani. In pathogenicity tests, all the tested fungi were pathogenic to guava, lemon and olive transplants. The effect of plant growth promoting rhizobacteria (PGPR) individually and/or mixed when used as a soil drench treatment were varied in reducing root rot/ wilt incidence and severity under greenhouse conditions compared with control. The mixed of PGPR gave the highest protection against root rot/wilt diseases compared with the use of PGPR individually. All treatments significantly increased plant height (cm), number of leaves transplanting-1, leaf area (cm2), fresh and dry weights transplanting-1 (gm) compared with control treatment

The potential gonadoprotective effects of grape seed extract against the histopathological alterations elicited in an animal model of cadmium-induced testicular toxicity

Background: Grape seed extract (GSE) is a powerful antioxidant containing high levels of bioflavonoids, vitamin C and vitamin E. The aim of the work is to study the possible protective and ameliorative effects of grape seed extract in an animal model of cadmium (Cd)-induced testicular toxicity in rats.Materials and methods: A thirty-day oral gavage study in adult male albino rats was performed using 32 animals, randomly divided into four equal groups; negative control, Cd (5 mg/k/day), GSE (100 mg/k/day), and Cd + GSE. Testicular weights were measured. Haematoxylin and eosin (H&amp;E) staining and proliferating nuclear cell antigen (PCNA) immunohistochemistry, as a marker for proliferation were done. Morphometric parameters were assessed and subjected to statistical analysis.Results: The H&amp;E results showed atrophy and distortion of the seminiferous tubules (STs) with sloughing of the spermatogenic epithelium in cadmium group. The interstitial spaces were widened and showed oedema and mononuclear cell infiltrations. No remarkable changes were observed in the GSE-only group when compared to the control group. In Cd + GSE group, maintaining of the STs and their lining cells was evident. The immunohistochemical results showed marked positive PCNA immunoreactivity in both control and GSE groups, while negative immunoreaction was noticed in Cd group. Limited positive PCNA immunoreactivity was ameliorated in Cd + GSE group.Conclusions: Grape seed extract protected against cadmium-induced testicular toxicity in rats, reducing induced histopathological changes, and maintaining testicular histoarchitecture

Stem cells and metformin synergistically promote healing in experimentally induced cutaneous wound injury in diabetic rats

Introduction. Diabetes mellitus (DM) is a serious, chronic metabolic disorder commonly complicated by diabetic foot ulcers with delayed healing. Metformin was found to have a wound healing effect through several mechanisms. The current study investigated the effect of both bone marrow-derived mesenchymal stem cells (BM-MSCs) and metformin, considered alone or combined, on the healing of an experimentally induced cutaneous wound injury in streptozotocin-induced diabetic rats.Material and methods. Forty adult male albino rats were used. Diabetes was induced by single intravenous (IV) injection of streptozotocin (STZ). Next, two circular full thickness skin wounds were created on the back of the animals, then randomly assigned into 4 groups, ten rats each. BM-MSCs were isolated from albino rats, 8 weeks of age and labeled by PKH26 before intradermal injection into rats of Group III and IV. Groups I (diabetic positive control), II (metformin-treated, 250 mg/kg/d), III (treated with 2×106 BM-MSCs), and IV (wounded rats treated both with metformin and BM-MSCs cells). Healing was assessed 3, 7, 14, and 21 days post wound induction through frequent measuring of wound diameters. Skin biopsies were obtained at the end of the experiment.Results. Gross evaluation of the physical healing of the wounds was done. Skin biopsies from the wound areas were processed for hematoxylin and eosin (H&amp;E), Masson’s trichrome staining and immunohistochemical staining for CD31. The results showed better wound healing in the combined therapy group (IV) as compared to monotherapy groups.Conclusions. Although both metformin and BM-MSCs were effective in the healing of experimentally induced skin wounds in diabetic rats, the combination of both agents appears to be a better synergistic option for the treatment of diabetic wound injuries

Improved bioavailability of timolol maleate via transdermal transfersomal gel: Statistical optimization, characterization, and pharmacokinetic assessment

AbstractTimolol maleate (TiM), a nonselective β-adrenergic blocker, is a potent highly effective agent for management of hypertension. The drug suffers from extensive first pass effect, resulting in a reduction of oral bioavailability (F%) to 50% and a short elimination half-life of 4h; parameters necessitating its frequent administration. The current study was therefore, designed to formulate and optimize the transfersomal TiM gel for transdermal delivery. TiM loaded transfersomal gel was optimized using two 23 full factorial designs; where the effects of egg phosphatidyl choline (PC): surfactant (SAA) molar ratio, solvent volumetric ratio, and the drug amount were evaluated. The formulation variables; including particle size, drug entrapment efficiency (%EE), and release rate were characterized. The optimized transfersomal gel was prepared with 4.65:1 PC:SAA molar ratio, 3:1 solvent volumetric ratio, and 13mg drug amount with particle size of 2.722μm, %EE of 39.96%, and a release rate of 134.49μg/cm2/h. The permeation rate of the optimized formulation through the rat skin was excellent (151.53μg/cm2/h) and showed four times increase in relative bioavailability with prolonged plasma profile up to 72h compared with oral aqueous solution. In conclusion, a potential transfersomal transdermal system was successfully developed and the factorial design was found to be a smart tool, when optimized

Available Technologies, Applications and Benefits of Teleorthodontics. A Literature Review and Possible Applications during the COVID-19 Pandemic

Background: COVID-2019 spread rapidly throughout the world from China. This infection is highly contagiousness, has a high morbidity, and is capable of evolving into a potentially lethal form of interstitial pneumonia. Numerous countries shut-down various activities that were considered "not essential." Dental treatment was in this category and, at the time of writing, only non-deferrable emergencies are still allowed in many countries. Therefore, follow-up visits of ongoing active therapies (e.g., orthodontic treatment) must be handled taking special precautions. This literature review aims at reducing in-office appointments by providing an overview of the technologies available and their reliability in the long-distance monitoring of patients, i.e., teledentistry. Methods: A literature review was made according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols (PRISMA-P) guidelines. Randomized clinical trials, cross sectional, observational, and case-control studies were evaluated with the Mixed Methods Appraisal Tool for quality assessment and study limitations. Results: A primary search found 80 articles, 69/80 were excluded as non-relevant on the basis of: the abstract, title, study design, bias, and/or lack of relevance. Twelve articles were included in the qualitative analysis. Conclusions: Teleorthodontics can manage most emergencies, reassuring and following patients remotely. The aim set by dental teleassistance was met as it reduced patients' office visits whilst maintaining regular monitoring, without compromising the results. Although our preliminary findings should be further investigated to objectively evaluate the efficacy, cost-effectiveness, and long-term results, we are confident that teleassistance in orthodontics will have a role to play in the near future