Systemic inflammation predicts all-cause mortality: a Glasgow Inflammation Outcome Study

Introduction: Markers of the systemic inflammatory response, including C-reactive protein and albumin (combined to form the modified Glasgow Prognostic Score), as well as neutrophil, lymphocyte and platelet counts have been shown to be prognostic of survival in patients with cancer. The aim of the present study was to examine the prognostic relationship between these markers of the systemic inflammatory response and all-cause, cancer, cardiovascular and cerebrovascular mortality in a large incidentally sampled cohort.<p></p> Methods: Patients (n = 160 481) who had an incidental blood sample taken between 2000 and 2008 were studied for the prognostic value of C-reactive protein (>10mg/l, albumin (>35mg/l), neutrophil (>7.5×109/l) lymphocyte and platelet counts. Also, patients (n = 52 091) sampled following the introduction of high sensitivity C-reactive protein (>3mg/l) measurements were studied. A combination of these markers, to make cumulative inflammation-based scores, were investigated.<p></p> Results: In all patients (n = 160 481) C-reactive protein (>10mg/l) (HR 2.71, p<0.001), albumin (>35mg/l) (HR 3.68, p<0.001) and neutrophil counts (HR 2.18, p<0.001) were independently predictive of all-cause mortality. These associations were also observed in cancer, cardiovascular and cerebrovascular mortality before and after the introduction of high sensitivity C-reactive protein measurements (>3mg/l) (n = 52 091). A combination of high sensitivity C-reactive protein (>3mg/l), albumin and neutrophil count predicted all-cause (HR 7.37, p<0.001, AUC 0.723), cancer (HR 9.32, p<0.001, AUC 0.731), cardiovascular (HR 4.03, p<0.001, AUC 0.650) and cerebrovascular (HR 3.10, p<0.001, AUC 0.623) mortality. Conclusion The results of the present study showed that an inflammation-based prognostic score, combining high sensitivity C-reactive protein, albumin and neutrophil count is prognostic of all-cause mortality

Emissions of biogenic sulfur gases from Alaskan tundra

Fluxes of the biogenic sulfur gases carbonyl sulfide (COS), dimethyl sulfide (DMS), methyl mercaptan (MeSH), and carbon disulfide (CS2) were determined for several freshwater and coastal marine tundra habitats using a dynamic enclosure method and gas chromatography. In the freshwater tundra sites, highest emissions, with a mean of 6.0 nmol/m(sup -2)H(sup -1) (1.5-10) occurred in the water-saturated wet meadow areas inhabited by grasses, sedges, and Sphagnum mosses. In the drier upland tundra sites, highest fluxes occurred in areas inhabited by mixed vegetation and labrador tea at 3.0 nmol/m(sup -2)h(sup -1) (0-8.3) and lowest fluxes were from lichen-dominated areas at 0.9 nmol/m(sup -2)h(sup -1). Sulfur emissions from a lake surface were also low at 0.8 nmol/m(sup -2)h(sup -1). Of the compounds measured, DMS was the dominant gas emitted from all of these sites. Sulfure emissions from the marine sites were up to 20-fold greater than fluxes in the freshwater habitats and were also dominated by DMS. Emissions of DMS were highest from intertidal soils inhabited by Carex subspathacea (150-250 nmol/m(sup -2)h(sup -1)). This Carex sp. was grazed thoroughly by geese and DMS fluxes doubled when goose feces were left within the flux chamber. Emissions were much lower from other types of vegetation which were more spatially dominant. Sulfure emissions from tundra were among the lowest reported in the literature. When emission data were extrapolated to include all tundra globally, the global flux of biogenic sulfur from this biome is 2-3 x 10(exp 8) g/yr. This represents less than 0.001 percent of the estimated annual global flux (approximately 50 Tg) of biogenic sulfur and less than 0.01 percent of the estimated terrestrial flux. The low emissions are attributed to the low availability of sulfate, certain hydrological characteristics of tundra, and the tendency for tundra to accumulate organic matter

Evaluating Multiple Arthropod Taxa as Indicators of Invertebrate Diversity in Old Fields

Biodiversity, often quantified by species richness, is commonly used to evaluate and monitor the health of ecosystems and as a tool for conservation planning. The use of one or more focal taxa as surrogates or indicators of larger taxonomic diversity can greatly expedite the process of biodiversity measurement. This is especially true when studying diverse and abundant invertebrate fauna. Before indicator taxa are employed, however, research into their suitability as indicators of greater taxonomic diversity in an area is needed. We sampled invertebrate diversity in old fields in southern Michigan using pitfall trapping and morphospecies designations after identification to order or family. Correlation analysis was used to assess species richness relationships between focal arthropod taxa and general invertebrate diversity. Relationships were assessed at two fine spatial scales: within sampling patches, and locally across four sampling patches. Cumulative richness of all assessed taxa increased proportionately with cumulative invertebrate richness as sampling intensity increased within patches. At the among-patch scale, we tentatively identified Hemiptera and Coleoptera as effective indicator taxa of greater invertebrate richness. Although Hymenoptera, Araneae and Diptera exhibited high species richness, their total richness within patches was not associated with overall invertebrate richness among patches. Increased sampling throughout the active season and across a greater number of habitat patches should be conducted before adopting Hemiptera and Coleoptera as definitive indicators of general invertebrate richness in the Great Lakes region. Multiple sampling techniques, in addition to pitfall trapping, should also be added to overcome capture biases associated with each technique

Anti-parasitic benzoxaboroles are ineffective against Theileria parva in vitro

East Coast Fever (ECF) is a disease affecting cattle in sub-Saharan Africa, caused by the tick-borne Apicomplexan pathogen Theileria parva. The disease is a major problem for cattle farmers in affected regions and there are few methods of control, including a complex infection and treatment vaccine, expensive chemotherapy, and the more widespread tick control through acaricides. New intervention strategies are, therefore, sorely needed. Benzoxaboroles are a versatile class of boron-heterocyclic compounds with demonstrable pharmacological activity against a diverse group of pathogens, including those related to T. parva. In this study, the in vitro efficacy of three benzoxaboroles against the intracellular schizont stage of T. parva was investigated using a flow cytometry approach. Of the benzoxaboroles tested, only one showed any potency, albeit only at high concentrations, even though there is high protein sequence similarity in the CPSF3 protein target compared to other protozoan pathogen species. This finding suggests that benzoxaboroles currently of interest for the treatment of African animal trypanosomiasis, toxoplasmosis, cryptosporidiosis and malaria may not be suitable for the treatment of ECF. We conclude that testing of further benzoxaborole compounds is needed to fully determine whether any lead compounds can be identified to target T. parva

Northeast Bathymetry and Backscatter Compilation: Western Gulf of Maine, Southern New England, and Long Island Sound

High-resolution bathymetry is critical for mapping the surficial geology of the seafloor, identifying critical habitats, and assessing marine mineral resources such as sand and gravel. In 2016, a high-resolution bathymetry map was developed for the western Gulf of Maine (WGOM) utilizing all available multibeam echosounder (MBES) surveys, as well as several older extant surveys (Western Gulf of Maine Bathymetry and Backscatter Synthesis, Ward et al., 2016). As part of that effort, a backscatter mosaic also was developed for a subset of the MBES surveys. The backscatter synthesis did not include all of the MBES surveys due to low quality of some of the mosaics and limitations of combining MBES backscatter surveys (e.g., different frequencies). In order to extend the high-resolution bathymetry coverage of the U.S. Northeast (NE), the WGOM Bathymetry and Backscatter Synthesis was substantially expanded. A careful review of the available bathymetry and backscatter from Maine to New York was conducted and the needed databases obtained. In addition, bathymetric lidar surveys were gathered, primarily in the WGOM. Unfortunately, the MBES coverage was relatively sparse over large areas of the NE region with few surveys available for mid and northern Maine, south of Cape Cod, and along the Atlantic coast of Long Island to New York Harbor. However, relatively good coverage exists for Long Island Sound. Similarly, high quality backscatter mosaics co-registered with the bathymetry was sparse. Nevertheless, the available bathymetry and backscatter does allow a significant expansion of the overall coverage and exposes areas where more information would be beneficial. Some low-resolution bathymetry data (e.g., single beam surveys that leave gaps between survey lines) were also obtained but were only used in a Regional Bathymetry Map. The “Northeast Bathymetry and Backscatter Compilation: Western Gulf of Maine, Southern New England, and Long Island Sound” expands the coverage of high-resolution MBES to include southern New England and Long Island Sound. The main bathymetry synthesis is gridded at 4m, 8m, and 16m. Also included are MBES bathymetry surveys that provide more detail of regions where research projects have been conducted by the University of New Hampshire (UNH) Center for Coastal and Ocean Mapping/Joint Hydrographic Center (CCOM/JHC). The overall backscatter coverage for the WGOM inner continental shelf is presented as compilations and individual survey mosaics (UNH CCOM/JHC surveys). South of Cape Cod to New York Harbor the backscatter is limited and presented as individual surveys where available

Greenland ice core “signal” characteristics: An expanded view of climate change

The last millenium of Earth history is of particular interest because it documents the environmental complexities of both natural variability and anthropogenic activity. We have analyzed the major ions contained in the Greenland Ice Sheet Project 2 (GISP 2) ice core from the present to ∼674 A.D. to yield an environmental reconstruction for this period that includes a description of nitrogen and sulfur cycling, volcanic emissions, sea salt and terrestrial influences. We have adapted and extended mathematical procedures for extracting sporadic (e.g., volcanic) events, secular trends, and periodicities found in the data sets. Finally, by not assuming that periodic components (signals) were “stationary” and by utilizing evolutionary spectral analysis, we were able to reveal periodic processes in the climate system which change in frequency, “turn on,” and “turn off” with other climate transitions such as\u27that between the little ice age and the medieval warm period

The effectiveness and variation of acute medical units: a systematic review

Purpose: To evaluate the evidence for the effectiveness of acute medical units (AMUs) compared with other models of care and compare the components of AMU models. Data sources: Six electronic databases and grey literature sources searched between 1990 and 2014. Study selection: Studies reporting on AMUs as an intervention for unplanned medical presentations to hospital with the inclusion of all outcome measures/study designs/comparators. Data extraction: Data on study characteristics/outcomes/AMU components were extracted by one author and confirmed by a second. Data synthesis: Seventeen studies of 12 AMUs across five countries were included. The AMU model was associated with a reduction in-hospital length of stay (LOS) in all analyses ranging from 0.3 to 2.6 days; and a reduction in mortality in 12 of the 14 analyses with the change ranging from a 0.1% increase to a 8.8% reduction. Evidence relating to readmissions and patient/staff satisfaction was less conclusive. There was variation in the following components of AMUs: admission criteria, entry sources, functions and consultant work patterns. Conclusion: This review provides evidence that AMUs are associated with reductions in-hospital LOS and, less convincingly, mortality compared with other models of care when implemented in European and Australasian settings. Reported estimates may be affected by residual confounding. This review reports heterogeneity in components of the AMU model. Further work to identify what constitutes the key components of an AMU is needed to improve the quality and effectiveness of acute medical care. This is of particular importance given the escalating demand on acute services