42,626 research outputs found

    Swashplate feedback control for tilt-rotor aircraft

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    Changes in angle of attack in system were sensed indirectly by gages which responded to strains induced in wing structure. Output signals were amplified, filtered, and used to activate swashplate actuators. System provided significant reduction in blade loads and desirable changes in hub forces and moments

    Wave Profile for Current Bearing Antiforce Waves

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    For fluid dynamical analysis of breakdown waves, we employ a one-dimensional, three-component (electrons, ions and neutral particles) fluid model to describe a steady-state, ionizing wave propagating counter to strong electric fields. The electron gas temperature and therefore the electron fluid pressure is assumed to be large enough to sustain the wave motion down the discharge tube. Such waves are referred to as antiforce waves. The complete set of equations describing such waves consists of the equations of conservation of mass, momentum and energy coupled with Poisson’s equation. Inclusion of current behind the wave front alters the set of electron fluid dynamical equations and also the boundary condition on electron temperature. For a range of experimentally observed current values, using the modified boundary condition on electron temperature, we have been able to integrate our modified set of electron fluid dynamical equations through the Debye layer. Our solutions meet the expected boundary conditions at the trailing edge of the wave. We present the wave profile for electric field, electron velocity, electron number density and electron temperature within the Debye layer of the wave

    Invasive Diseases and Fruit Tree Production: Economic Tradeoffs of Citrus Greening Control on Florida's Citrus Industry

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    An investment model of Florida oranges was used to evaluate various management strategies for controlling Huanglongbing, or citrus greening, a highly destructive disease. This analysis will enable the Florida citrus industry to make more informed decisions about the economic tradeoffs among current citrus greening management alternatives.Crop Production/Industries,

    Coal-shale interface detection system

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    A coal-shale interface detection system for use with coal cutting equipment consists of a reciprocating hammer on which an accelerometer is mounted to measure the impact of the hammer as it penetrates the ceiling or floor surface of a mine. A pair of reflectometers simultaneously view the same surface. The outputs of the accelerometer and reflectometers are detected and jointly registered to determine when an interface between coal and shale is being cut through

    Epilepsy-specific patient-reported outcome measures of children's health-related quality of life: A systematic review of measurement properties.

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    This is the final version. Available from the publisher via the DOI in this record.OBJECTIVE: To identify and appraise published evidence of the measurement properties for epilepsy-specific patient-reported outcome measures (PROMs) of children's health-related quality of life (HRQoL). METHODS: We searched multiple databases for studies evaluating the measurement properties of English-language epilepsy-specific PROMs of children's HRQoL. We assessed the methodological quality using the COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) guidance. We extracted data about the content validity, construct validity, internal consistency, test-retest reliability, proxy reliability, responsiveness, and precision, and assessed the measurement properties with reference to standardized criteria. RESULTS: We identified 27 papers that evaluated 11 PROMs. Methodological quality was variable. Construct validity, test-retest reliability, and internal consistency were more commonly assessed. Quality of Life in Childhood Epilepsy (QoLCE) questionnaires are parent-reported and evaluated more than other PROMs; QoLCE-55 has good and replicated evidence for structural and construct validity and internal consistency. Health-Related Quality of Life Measure for Children with Epilepsy (CHEQoL) has both child and parent-reported versions and good evidence of content, structural, and construct validity. SIGNIFICANCE: This review identified two leading candidate epilepsy-specific PROMs for measuring health-related quality of life in children. Establishing evidence of the responsiveness of PROMs is a priority to help the interpretation of meaningful change scores.National Institute for Health Research (NIHR

    Role of the unique N-terminal domain of CtBP2 in determining the subcellular localisation of CtBP family proteins

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    BACKGROUND: CtBP1 and CtBP2 are transcriptional co-repressors that modulate the activity of a large number of transcriptional repressors via the recruitment of chromatin modifiers. Many CtBP-regulated proteins are involved in pathways associated with tumorigenesis, including TGF-beta and Wnt signalling pathways and cell cycle regulators such as RB/p130 and HDM2, as well as adenovirus E1A. CtBP1 and CtBP2 are highly similar proteins, although evidence is emerging that their activity can be differentially regulated, particularly through the control of their subcellular localisation. CtBP2s from diverse species contain a unique N-terminus, absent in CtBP1 that plays a key role in controlling the nuclear-cytoplasmic distribution of the protein.RESULTS: Here we show that amino acids (a.a.) 4-14 of CtBP2 direct CtBP2 into an almost exclusively nuclear distribution in cell lines of diverse origins. Whilst this sequence contains similarity to known nuclear localisation motifs, it cannot drive nuclear localisation of a heterologous protein, but rather has been shown to function as a p300 acetyltransferase-dependent nuclear retention sequence. Here we define the region of CtBP2 required to co-operate with a.a. 4-14 to promote CtBP2 nuclear accumulation as being within a.a. 1-119. In addition, we show that a.a. 120-445 of CtBP2 can also promote CtBP2 nuclear accumulation, independently of a.a. 4-14. Finally, CtBP1 and CtBP2 can form heterodimers, and we show that the interaction with CtBP2 is one mechanism whereby CtBP1 can be recruited to the nucleus.CONCLUSION: Together, these findings represent key distinctions in the regulation of the functions of CtBP family members that may have important implications as to their roles in development, and cell differentiation and survival.<br/

    Acoustically excited heated jets. 3: Mean flow data

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    This is Part 3 of a report on the excitability of heated jets under the influence of acoustic excitation. The effects of upstream internal acoustic excitation on jet mixing were described in Part 1. Part 2 described the effects of external excitation on flow mixing. Part 3 contains quantitative results from the measurements of mean Mach number and temperature and consists of radial profiles and centerline distributions measured at selected jet operating conditions for internally excited and unexcited jets. The mean flow data are presented in both graphical and tabulated forms. For the sake of completeness, this part contains temperature probe calibration curves also

    Public geographies II: being organic

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    This second report on ‘public geographies' considers the diverse, emergent and shifting spaces of engaging with and in public/s. Taking as its focus the more ‘organic’ rather than ‘traditional’ approach to doing public geography, as discussed in the first report, it explores the multiple and unorthodox ways in which engagements across academic-public spheres play out, and what such engagements may mean for geography/ers. The report first explores the role of the internet in ‘enabling conversations', generating a range of opportunities for public geography through websites, wikis, blogs, file-sharing sites, discussion forums and more, thinking critically about how technologies may enable/disable certain kinds of publically engaged activities. It then considers issues of process and praxis: how collaborations with groups/communities/organizations beyond academia are often unplanned, serendipitous encounters that evolve organically into research/learning/teaching endeavours; but also that personal politics/positionality bring an agency to bear upon whether we, as academics, follow the leads we may stumble upon. The report concludes with a provocative question – given that many non-academics appear to be doing some amazing and inspiring projects and activities, thoughtful, critical and (arguably) examples of organic public geographies, what then is academia’s role
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