Development of a Low-Cost Robotics Platform that Facilitates the Enhancement of Microcomputer Structures and Interfacing Learning Objectives

Robotics has become a common educational tool to teach basic concepts in mathematics, science, engineering, technology, world affairs, and much more. Programs such as For Inspiration and Recognition of Science and Technology (FIRST) robotics are demonstrating that the recipe for student inspiration and learning involves robotics, problem solving, teamwork, and friendly competition. The successes of FIRST robotics programs and results from universities that have integrated robotics platforms into their curriculum provide evidence that infusing robotics platforms and curriculum into engineering departments better their capabilities and increase attractiveness to current and future students. This effort details the design and development of a low-cost robotics platform and seamless set of supporting curriculum. The platform and seamless curriculum set is implemented in the West Virginia University\u27s Lane Department of Computer Science and Electrical Engineering (LCSEE) microcomputer structures and interfacing laboratory, an undergraduate computer engineering course. The results provide detailed information on the robotics platform as well as detailed information on the seamless set of modules that make up the curriculum. The results demonstrate that a subset of students become significantly more motivated and are more willing to work additional hours to improve upon their design as compared to traditional laboratory sessions. These results are significant and demonstrate that robotics and seamless curriculum sets provide a solid platform to introduce computer engineering concepts that inspire and motivate students

Nature Versus Nurture: Luminous Blue Variable Nebulae in and near Massive Stellar Clusters at the Galactic Center

Three Luminous Blue Variables (LBVs) are located in and near the Quintuplet Cluster at the Galactic Center: the Pistol star, G0.120-0.048, and qF362. We present imaging at 19, 25, 31, and 37 {\mu}m of the region containing these three LBVs, obtained with SOFIA using FORCAST. We argue that the Pistol and G0.120-0.048 are identical ``twins" that exhibit contrasting nebulae due to the external influence of their different environments. Our images reveal the asymmetric, compressed shell of hot dust surrounding the Pistol Star and provide the first detection of the thermal emission from the symmetric, hot dust envelope surrounding G0.120-0.048. Dust and gas composing the Pistol nebula are primarily heated and ionized by the nearby Quintuplet Cluster stars. The northern region of the Pistol nebula is decelerated due to the interaction with the high-velocity (2000 km/s) winds from adjacent Wolf-Rayet Carbon (WC) stars. With the DustEM code we determine that the Pistol nebula is composed of a distribution of very small, transiently-heated grains (10-~35 {\AA}) and that it exhibits a gradient of decreasing grain size from the south to the north due to differential sputtering by the winds from the WC stars. Dust in the G0.120-0.048 nebula is primarily heated by the central star; however, the nebular gas is ionized externally by the Arches Cluster. Unlike the Pistol nebula, the G0.120-0.048 nebula is freely expanding into the surrounding medium. Given independent dust and gas mass estimates we find that the Pistol and G0.120-0.048 nebulae exhibit similar gas-to-dust mass ratios of ~310 and ~290, respectively. Both nebulae share identical size scales (~ 0.7 pc) which suggests that they have similar dynamical timescales of ~10^5 yrs, assuming a shell expansion velocity of v_exp 60 km/s.Comment: 18 pages, 7 figures, accepted to Ap

Lack of evidence for decreased protein stability in the 2397 (Met) haplotype of the leucine rich repeat kinase 2 protein implicated in Parkinson’s disease

Missense mutations in the leucine rich repeat kinase 2 (LRRK2) gene are the leading genetic cause of autosomal dominant familial Parkinson’s disease. We previously reported that two mutations within the ROC domain, namely R1441C and A1442P, exhibit increased protein degradation leading to lowered steady state LRRK2 protein levels in HEK293 cells. More recently, the common WD40 domain LRRK2 haplotype, Met2397, which is a risk factor for Crohn’s disease, has been shown to lower steady state protein levels in HEK293 cells. In view of recent evidence implicating LRRK2 and inflame-mation in PD, we investigated the effects of Met2397 on LRRK2 expression, and compared them to the Thr2397 variant and other LRRK2 mutants. In this study, we transfected HEK293 cells with plasmid constructs encoding the different LRRK2 variants, and analyzed the resulting protein levels by Western blot and flow cytometry. Here we found that both the Met2397 and Thr2397 haplotypes yield similar levels of LRRK2 protein expression and do not appear to impact cell viability in HEK293 cells, compared to other LRRK mutants. Thus, we have concluded that the Met2397 haplotype is unlikely to play a role in LRRK2 mediated or idiopathic PD

Physiotherapy Students’ and Practice Educators’ Experiences of Using Placements Passports: A Tool to Enhance Collaboration on Placement

Integral to physiotherapy students’ study are their practice placements. Placements form a mandatory part of students’ programmes of study. Practice learning is seen as an essential component of the curricula and as such is a key element of the students’ learning and development. The UK health service, which continues to provide the majority of practice learning opportunities for healthcare students, is experiencing unprecedented demand on services. Practice educators are reporting increasing pressure to maintain service provision whilst trying to support students in the practice setting. To maximise learning on placement, the placement passport was developed. This aims to support a more collaborative approach to the student’s learning in practice, by promoting a partnership between the practice educator and the student, and by encouraging and enabling the students to develop their skills of self-evaluation and self-directed learning, but also giving the practice educator the opportunity to try to tailor the experience to the student’s needs and wants. This study aims to explore students’ and practice educators’ experiences of using a placement passport in physiotherapy education. Five students and four practice educators attended one-off focus groups to explore their experiences. Findings suggested that the passport is a tool to support collaborative approaches to students’ learning, helping students and practice educators to bridge the gap between academia and the reality of practice. It also provided both with the opportunity to begin early dialogue around the students’ and practice educators’ expectations of the practice placement while acknowledging prior learning and development.                                                                                                                                 &nbsp

Old supernova dust factory revealed at the Galactic center

Dust formation in supernova ejecta is currently the leading candidate to explain the large quantities of dust observed in the distant, early Universe. However, it is unclear whether the ejecta-formed dust can survive the hot interior of the supernova remnant (SNR). We present infrared observations of ~0.02 $M_\odot$ of warm (~100 K) dust seen near the center of the ~10,000 yr-old Sgr A East SNR at the Galactic center. Our findings signify the detection of dust within an older SNR that is expanding into a relatively dense surrounding medium ($n_e$ ~ 100 $\mathrm{cm}^{-3}$) and has survived the passage of the reverse shock. The results suggest that supernovae may indeed be the dominant dust production mechanism in the dense environment of early Universe galaxies.Comment: 25 pages, 5 figures. Includes supplementary materials. Published Online March 19 2015 on Science Expres