Student perceptions of their autonomy at University

© 2017, The Author(s). Learner autonomy is a primary learning outcome of Higher Education in many countries. However, empirical evaluation of how student autonomy progresses during undergraduate degrees is limited. We surveyed a total of 636 students’ self-perceived autonomy during a period of two academic years using the Autonomous Learning Scale. Our analysis suggests that students do not perceive themselves as being any more autonomous as they progress through University. Given the relativity of self-perception metrics, we suggest that our results evince a “red queen” effect. In essence, as course expectations increase with each year, each student’s self-perceived autonomy relative to their ideal remains constant; we term this the “moving goalpost” hypothesis. This article corroborates pedagogical literature suggesting that providing students with opportunities to act autonomously and develop confidence is key to developing graduates who have the independence that they need in order to be successful in the workplace

Primary pulmonary hypertension is associated with reduced pulmonary vascular expression of type II bone morphogenetic protein receptor

BACKGROUND: Mutations in the type II receptor for bone morphogenetic protein (BMPR-II), a receptor member of the transforming growth factor-beta (TGF-beta) superfamily, underlie many familial and sporadic cases of primary pulmonary hypertension (PPH). METHODS AND RESULTS: Because the sites of expression of BMPR-II in the normal and hypertensive lung are unknown, we studied the cellular localization of BMPR-II and the related type I and II receptors for TGF-beta by immunohistochemistry in lung sections from patients undergoing heart-lung transplantation for PPH (n=11, including 3 familial cases) or secondary pulmonary hypertension (n=6) and from unused donor lungs (n=4). In situ hybridization was performed for BMPR-II mRNA. Patients were screened for the presence of mutations in BMPR2. In normal lungs, BMPR-II expression was prominent on vascular endothelium, with minimal expression in airway and arterial smooth muscle. In pulmonary hypertension cases, the intensity of BMPR-II immunostaining varied between lesions but involved endothelial and myofibroblast components. Image analysis confirmed that expression of BMPR-II was markedly reduced in the peripheral lung of PPH patients, especially in those harboring heterozygous BMPR2 mutations. A less marked reduction was also observed in patients with secondary pulmonary hypertension. In contrast, there was no difference in level of staining for TGF-betaRII or the endothelial marker CD31. CONCLUSIONS: The cellular localization of BMPR-II is consistent with a role in the formation of pulmonary vascular lesions in PPH, and reduced BMPR-II expression may contribute to the process of vascular obliteration in severe pulmonary hypertension

Functional interaction between BMPR-II and Tctex-1, a light chain of Dynein, is isoform-specific and disrupted by mutations underlying primary pulmonary hypertension

Diverse heterozygous mutations of bone morphogenetic receptor type II (BMPR-II) underlie the inherited form of the vascular disorder primary pulmonary hypertension (PPH). As yet, the molecular detail of how such defects contribute to the pathogenesis of PPH remains unclear. BMPR-II is a member of the transforming growth factor-beta cell signalling superfamily. Ligand binding induces cell surface receptor complex formation and activates a cascade of phosphorylation events of intracellular intermediaries termed Smads, which initiate transcriptional regulation. Some 30% of PPH-causing mutations localize to exon 12, which may be spliced out forming an isoform depleted of the unusually long BMPR-II cytoplasmic tail. To further elucidate the consequences of BMPR2 mutation, we sought to characterize aspects of the cytoplasmic domain function by seeking intracellular binding partners. We now report that Tctex-1, a light chain of the motor complex dynein, interacts with the cytoplasmic domain of BMPR-II and demonstrate that Tctex-1 is phosphorylated by BMPR-II, a function disrupted by PPH disease causing mutations within exon 12. Finally we show that BMPR-II and Tctex-1 co-localize to endothelium and smooth muscle within the media of pulmonary arterioles, key sites of vascular remodelling in PPH. Taken together, these data demonstrate a discrete function for the cytoplasmic domain of BMPR-II and justify further investigation of whether the interaction with and phosphorylation of Tctex-1 contributes to the pathogenesis of PPH

A Parallel Elastic Haptic Thimble for Wide Bandwidth Cutaneous Feedback.

Design of wearable fingertip haptic devices is often a compromise between conflicting features: lightness and compactness, against rich and neat haptic feedback. On one side direct drive actuators (i.e. voice coils) provide a clean haptic feedback with high dynamics, with limited maximum output forces. On the other side mechanical transmissions with reduction can increase output force of micro sized motors, at the cost of slower and often noisy output signals. In this work we present a compact fingertip haptic device based on a parallel elastic mechanism: it merges the output of two differently designed actuators in a single, wide bandwidth haptic feedback. Each actuator is designed with a different role: one for rendering fast, high frequency force components, the other for rendering constant to low frequency components. In the work we present design and implementation of the device, followed by experimental characterization of its performance in terms of frequency response and rendering capabilities

The Old Host-Galaxy Environment of SSS17a, the First Electromagnetic Counterpart to a Gravitational Wave Source

We present an analysis of the host-galaxy environment of Swope Supernova Survey 2017a (SSS17a), the discovery of an electromagnetic counterpart to a gravitational wave source, GW170817. SSS17a occurred 1.9 kpc (in projection; 10.2") from the nucleus of NGC 4993, an S0 galaxy at a distance of 40 Mpc. We present a Hubble Space Telescope (HST) pre-trigger image of NGC 4993, Magellan optical spectroscopy of the nucleus of NGC 4993 and the location of SSS17a, and broad-band UV through IR photometry of NGC 4993. The spectrum and broad-band spectral-energy distribution indicate that NGC 4993 has a stellar mass of log (M/M_solar) = 10.49^{+0.08}_{-0.20} and star formation rate of 0.003 M_solar/yr, and the progenitor system of SSS17a likely had an age of >2.8 Gyr. There is no counterpart at the position of SSS17a in the HST pre-trigger image, indicating that the progenitor system had an absolute magnitude M_V > -5.8 mag. We detect dust lanes extending out to almost the position of SSS17a and >100 likely globular clusters associated with NGC 4993. The offset of SSS17a is similar to many short gamma-ray burst offsets, and its progenitor system was likely bound to NGC 4993. The environment of SSS17a is consistent with an old progenitor system such as a binary neutron star system.Comment: ApJL in pres

The Carnegie Supernova Project I: methods to estimate host-galaxy reddening of stripped-envelope supernovae

We aim to improve upon contemporary methods to estimate host-galaxy reddening of stripped-envelope (SE) supernovae (SNe). To this end the Carnegie Supernova Project (CSP-I) SE SNe photometry data release, consisting of nearly three dozen objects, is used to identify a minimally reddened sub-sample for each traditionally defined spectroscopic sub-types (i.e, SNe~IIb, SNe~Ib, SNe~Ic). Inspection of the optical and near-infrared (NIR) colors and color evolution of the minimally reddened sub-samples reveals a high degree of homogeneity, particularly between 0d to +20d relative to B-band maximum. This motivated the construction of intrinsic color-curve templates, which when compared to the colors of reddened SE SNe, yields an entire suite of optical and NIR color excess measurements. Comparison of optical/optical vs. optical/NIR color excess measurements indicates the majority of the CSP-I SE SNe suffer relatively low amounts of reddening and we find evidence for different R_(V)^(host) values among different SE SN. Fitting the color excess measurements of the seven most reddened objects with the Fitzpatrick (1999) reddening law model provides robust estimates of the host visual-extinction A_(V)^(host) and R_(V)^(host). In the case of the SE SNe with relatively low amounts of reddening, a preferred value of R_(V)^(host) is adopted for each sub-type, resulting in estimates of A_(V)^(host) through Fitzpatrick (1999) reddening law model fits to the observed color excess measurements. Our analysis suggests SE SNe reside in galaxies characterized by a range of dust properties. We also find evidence SNe Ic are more likely to occur in regions characterized by larger R_(V)^(host) values compared to SNe IIb/Ib and they also tend to suffer more extinction. These findings are consistent with work in the literature suggesting SNe Ic tend to occur in regions of on-going star formation.Comment: Abstract abridged to fit allowed limit. Resubmitted to A&A, 34 pages, 19 figures, 6 tables. Constructive comments welcome

Elevated levels of inflammatory cytokines predict survival in idiopathic and familial pulmonary arterial hypertension

BACKGROUND: Inflammation is a feature of pulmonary arterial hypertension (PAH), and increased circulating levels of cytokines are reported in patients with PAH. However, to date, no information exists on the significance of elevated cytokines or their potential as biomarkers. We sought to determine the levels of a range of cytokines in PAH and to examine their impact on survival and relationship to hemodynamic indexes. METHODS AND RESULTS: We measured levels of serum cytokines (tumor necrosis factor-alpha, interferon-gamma and interleukin-1beta, -2, -4, -5, -6, -8, -10, -12p70, and -13) using ELISAs in idiopathic and heritable PAH patients (n=60). Concurrent clinical data included hemodynamics, 6-minute walk distance, and survival time from sampling to death or transplantation. Healthy volunteers served as control subjects (n=21). PAH patients had significantly higher levels of interleukin-1beta, -2, -4, -6, -8, -10, and -12p70 and tumor necrosis factor-alpha compared with healthy control subjects. Kaplan-Meier analysis showed that levels of interleukin-6, 8, 10, and 12p70 predicted survival in patients. For example, 5-year survival with interleukin-6 levels of >9 pg/mL was 30% compared with 63% for patients with levels < or = 9 pg/mL (P=0.008). In this PAH cohort, cytokine levels were superior to traditional markers of prognosis such as 6-minute walk distance and hemodynamics. CONCLUSIONS: This study illustrates dysregulation of a broad range of inflammatory mediators in idiopathic and familial PAH and demonstrates that cytokine levels have a previously unrecognized impact on patient survival. They may prove to be useful biomarkers and provide insight into the contribution of inflammation in PAH

A Comprehensive Archival Search for Counterparts to Ultra-Compact High Velocity Clouds: Five Local Volume Dwarf Galaxies

We report five Local Volume dwarf galaxies (two of which are presented here for the first time) uncovered during a comprehensive archival search for optical counterparts to ultra-compact high velocity clouds (UCHVCs). The UCHVC population of HI clouds are thought to be candidate gas-rich, low mass halos at the edge of the Local Group and beyond, but no comprehensive search for stellar counterparts to these systems has been presented. Careful visual inspection of all publicly available optical and ultraviolet imaging at the position of the UCHVCs revealed six blue, diffuse counterparts with a morphology consistent with a faint dwarf galaxy beyond the Local Group. Optical spectroscopy of all six candidate dwarf counterparts show that five have an H$\alpha$-derived velocity consistent with the coincident HI cloud, confirming their association, the sixth diffuse counterpart is likely a background object. The size and luminosity of the UCHVC dwarfs is consistent with other known Local Volume dwarf irregular galaxies. The gas fraction ($M_{HI}/M_{star}$) of the five dwarfs are generally consistent with that of dwarf irregular galaxies in the Local Volume, although ALFALFA-Dw1 (associated with ALFALFA UCHVC HVC274.68+74.70$-$123) has a very high $M_{HI}/M_{star}$$\sim$40. Despite the heterogenous nature of our search, we demonstrate that the current dwarf companions to UCHVCs are at the edge of detectability due to their low surface brightness, and that deeper searches are likely to find more stellar systems. If more sensitive searches do not reveal further stellar counterparts to UCHVCs, then the dearth of such systems around the Local Group may be in conflict with $\Lambda$CDM simulations.Comment: 18 pages, 4 tables, 4 figures, ApJ Accepte